scholarly journals Chondroitin Sulfate Acts in Concert with Semaphorin 3A to Guide Tangential Migration of Cortical Interneurons in the Ventral Telencephalon

2010 ◽  
Vol 20 (10) ◽  
pp. 2411-2422 ◽  
Author(s):  
Geraldine Zimmer ◽  
Sheine M. Schanuel ◽  
Susanne Bürger ◽  
Franco Weth ◽  
André Steinecke ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Semaphorin 3A ◽  
Ventral Telencephalon ◽  
Tangential Migration ◽  
Cortical Interneurons

scholarly journals Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice

2012 ◽  
Vol 7 (1) ◽  
pp. 2 ◽  
Author(s):  
Konstantinos Zarbalis ◽  
Youngshik Choe ◽  
Julie A Siegenthaler ◽  
Lori A Orosco ◽  
Samuel J Pleasure
Keyword(s):  
Tangential Migration ◽  
Cortical Interneurons

scholarly journals Semaphorin 3C attracts MGE-derived cortical interneurons in the deep migratory stream guiding them into the developing neocortex

2021 ◽  
Author(s):  
Kiara Aiello ◽  
Jurgen Bolz
Keyword(s):  
Potential Role ◽  
Inhibitory Neurons ◽  
Semaphorin 3A ◽  
Cortical Interneuron ◽  
Guidance Cue ◽  
Cortical Interneurons ◽  
Developing Neocortex ◽  
Dorsal Telencephalon ◽  
Migratory Stream

While it is known that Semaphorin 3C acts as a guidance cue for axons during brain development, their potential role during interneuron migration is largely unknown. One striking observation is that Sema3C demarcates the pallial/subpallial border and the intracortical pathway of cortical interneurons in the dorsal telencephalon. Moreover, migrating cortical interneurons express Neuropilin1 and Neuropilin2, described receptors for Semaphorin 3A, 3F and 3C. All these reasons prompt us to examine possible roles for Sema3C on cortical interneuron migration. Using several in vitro approaches, we showed that Nrp1-expressing MGE-derived interneurons from the deep migratory stream migrate towards the increasing Sema3C gradients. In contrast, inhibitory neurons from the superficial migratory stream that express Nrp2, do not respond to this guidance cue. In the present study, we proposed that diffusible Sema3C expressed in the Pallium provides a permissive corridor that attracts the Nrp1- expressing interneurons from the DMS into the dorsal telencephalon.

scholarly journals N-Cadherin Sustains Motility and Polarity of Future Cortical Interneurons during Tangential Migration

2013 ◽  
Vol 33 (46) ◽  
pp. 18149-18160 ◽  
Author(s):  
C. Luccardini ◽  
L. Hennekinne ◽  
L. Viou ◽  
M. Yanagida ◽  
F. Murakami ◽  
...  
Keyword(s):  
Tangential Migration ◽  
Cortical Interneurons

scholarly journals JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons

Development ◽  
2020 ◽  
Vol 147 (2) ◽  
pp. dev180646 ◽  
Author(s):  
Abigail K. Myers ◽  
Jessica G. Cunningham ◽  
Skye E. Smith ◽  
John P. Snow ◽  
Catherine A. Smoot ◽  
...  
Keyword(s):  
Jnk Signaling ◽  
Tangential Migration ◽  
Cortical Interneurons

scholarly journals Developmental Characterization of Zswim5 Expression in the Progenitor Domains and Tangential Migration Pathways of Cortical Interneurons in the Mouse Forebrain

2019 ◽  
Author(s):  
Chuan-Chie Chang ◽  
Hsiao-Ying Kuo ◽  
Shih-Yun Chen ◽  
Kuan-Ming Lu ◽  
Weng Lam Fong ◽  
...  
Keyword(s):  
Cell Fate ◽  
Expression Pattern ◽  
Ganglionic Eminence ◽  
Double Labeling ◽  
Tangential Migration ◽  
Cortical Interneurons ◽  
Low Levels ◽  
Migration Pathways

ABSTRACTGABAergic interneurons play an essential role in modulating cortical networks. The progenitor domains of cortical interneurons are localized in developing ventral forebrain, including the medial ganglionic eminence (MGE), caudal ganglionic eminence (CGE), preoptic area (POA) and preoptic hypothalamic border domain (POH). Here, we characterized the expression pattern of Zswim5, an MGE-enriched gene in the mouse forebrain. At E11.5 to E13.5, prominent Zswim5 expression was detected in the subventricular zone (SVZ) of MGE, CGE, POA and POH of ventral telencephalon in which progenitors of cortical interneurons resided. At E15.5 and E17.5, Zswim5 remained detectable in the SVZ of pallidal primordium (MGE). Zswim5 mRNA was markedly decreased after birth and was absent in the adult forebrain. Interestingly, Zswim5 expression pattern resembled the tangential migration pathways of cortical interneurons. Zswim5-positive cells in the MGE appeared to migrate from the MGE through the SVZ of LGE to overlying neocortex. Indeed, Zswim5 was co-localized with Nkx2.1 and Lhx6, markers of progenitos and migratory cortical interneurons. Double labeling showed that Mash1/Ascl1-positive cells did not express Zswim5. Zswim5 expressing cells showed none or at most low levels of Ki67 but co-expressed Tuj1 in the SVZ of MGE. These results suggest that Zswim5 is immediately upregulated as progenitors exiting cell cycle to become postmitotic. Given that recent studies have elucidated that the cell fate of cortical interneurons is determined shortly after postmitotic, the timing of Zswim5 expression in early postmitotic cortical interneurons suggests a potential role of Zswim5 in regulation of neurogenesis and tangential migration of cortical interneurons.

scholarly journals Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and maturation

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Matthieu Genestine ◽  
Daisy Ambriz ◽  
Gregg W Crabtree ◽  
Patrick Dummer ◽  
Anna Molotkova ◽  
...  
Keyword(s):  
Critical Role ◽  
Mouse Development ◽  
Paracrine Factors ◽  
Embryonic Mouse ◽  
Tangential Migration ◽  
Mouse Cortex ◽  
Neuropsychiatric Diseases ◽  
Cortical Interneurons ◽  
Progenitor Domain ◽  
Pre Treatment

Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric diseases. Developmentally, interneurons migrate from a distal progenitor domain in order to populate the neocortex - a process that occurs at a slower rate in humans than in mice. In this study, we sought to identify factors that regulate the rate of interneuron maturation across the two species. Using embryonic mouse development as a model system, we found that the process of initiating interneuron migration is regulated by blood vessels of the medial ganglionic eminence (MGE), an interneuron progenitor domain. We identified two endothelial cell-derived paracrine factors, SPARC and SerpinE1, that enhance interneuron migration in mouse MGE explants and organotypic cultures. Moreover, pre-treatment of human stem cell-derived interneurons (hSC-interneurons) with SPARC and SerpinE1 prior to transplantation into neonatal mouse cortex enhanced their migration and morphological elaboration in the host cortex. Further, SPARC and SerpinE1-treated hSC-interneurons also exhibited more mature electrophysiological characteristics compared to controls. Overall, our studies suggest a critical role for CNS vasculature in regulating interneuron developmental maturation in both mice and humans.

scholarly journals Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons

2013 ◽  
Vol 25 (4) ◽  
pp. 991-1003 ◽  
Author(s):  
Sonja Rakić ◽  
Shigeaki Kanatani ◽  
David Hunt ◽  
Clare Faux ◽  
Anna Cariboni ◽  
...  
Keyword(s):  
Tangential Migration ◽  
Cortical Interneurons

The adhesion molecule TAG-1 mediates the migration of cortical interneurons from the ganglionic eminence along the corticofugal fiber system

Development ◽  
2001 ◽  
Vol 128 (22) ◽  
pp. 4635-4644 ◽  
Author(s):  
Myrto Denaxa ◽  
Chun-Hung Chan ◽  
Melitta Schachner ◽  
John G. Parnavelas ◽  
Domna Karagogeos
Keyword(s):  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Ganglionic Eminence ◽  
Fiber System ◽  
Ventral Telencephalon ◽  
Binding Partner ◽  
Neural Cell Adhesion ◽  
Cortical Interneurons ◽  
Migratory Routes ◽  
Dorsal Telencephalon

Cortical nonpyramidal cells, the GABA-containing interneurons, originate mostly in the medial ganglionic eminence of the ventral telencephalon and follow tangential migratory routes to reach the dorsal telencephalon. Although several genes that play a role in this migration have been identified, the underlying cellular and molecular cues are not fully understood. We provide evidence that the neural cell adhesion molecule TAG-1 mediates the migration of cortical interneurons. We show that the migration of these neurons occurs along the TAG-1-expressing axons of the developing corticofugal system. The spatial and temporal pattern of expression of TAG-1 on corticofugal fibers coincides with the order of appearance of GABAergic cells in the developing cortex. Blocking the function of TAG-1, but not of L1, another adhesion molecule and binding partner of TAG-1, results in a marked reduction of GABAergic neurons in the cortex. These observations reveal a mechanism by which the adhesion molecule TAG-1, known to be involved in axonal pathfinding, also takes part in neuronal migration.

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