scholarly journals Anterior thalamic lesions stop synaptic plasticity in retrosplenial cortex slices: expanding the pathology of diencephalic amnesia

Brain ◽  
2009 ◽  
Vol 132 (7) ◽  
pp. 1847-1857 ◽  
Author(s):  
D. L. F. Garden ◽  
P. V. Massey ◽  
D. A. Caruana ◽  
B. Johnson ◽  
E. C. Warburton ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Retrosplenial Cortex ◽  
Diencephalic Amnesia ◽  
Thalamic Lesions ◽  
Cortex Slices

Anterior thalamic lesions reduce spine density in both hippocampal CA1 and retrosplenial cortex, but enrichment rescues CA1 spines only

Hippocampus ◽  
2014 ◽  
Vol 24 (10) ◽  
pp. 1232-1247 ◽  
Author(s):  
Bruce C. Harland ◽  
David A. Collings ◽  
Neil McNaughton ◽  
Wickliffe C. Abraham ◽  
John C. Dalrymple-Alford
Keyword(s):  
Retrosplenial Cortex ◽  
Spine Density ◽  
Hippocampal Ca1 ◽  
Thalamic Lesions

scholarly journals Mammillothalamic disconnection alters hippocampo-cortical oscillatory activity and microstructure: Implications for diencephalic amnesia

2019 ◽  
Author(s):  
CM Dillingham ◽  
MM Milczarek ◽  
JC Perry ◽  
BE Frost ◽  
GD Parker ◽  
...  
Keyword(s):  
Paradoxical Sleep ◽  
Retrosplenial Cortex ◽  
Oscillatory Activity ◽  
Memory Processes ◽  
Mammillary Bodies ◽  
State Dependent ◽  
Diencephalic Amnesia ◽  
Mammillothalamic Tract ◽  
The Impact ◽  
Regional Synchrony

AbstractDiencephalic amnesia can be as disruptive as the more commonly known temporal lobe amnesia, yet the precise contribution of diencephalic structures to memory processes remains elusive. We used discrete lesions of the mammillothalamic tract to model aspects of diencephalic amnesia and assessed the impact of these lesions on multiple measures of activity and plasticity within the hippocampus and retrosplenial cortex. Lesions of the mammillothalamic tract had widespread indirect effects on hippocampo-cortical oscillatory activity within both theta and gamma bands. Both within-region oscillatory activity and cross-regional synchrony were altered. The network changes were state-dependent, displaying different profiles during locomotion and paradoxical sleep. Consistent with the associations between oscillatory activity and plasticity, complementary analyses using several convergent approaches revealed microstructural changes, which appeared to reflect a suppression of learning-induced plasticity in lesioned animals. Together, these combined findings suggest a mechanism by which damage to the medial diencephalon can impact upon learning and memory processes, highlighting important role for the mammillary bodies in the co-ordination of hippocampo-cortical activity.

scholarly journals Synaptic plasticity in the piriform cortex slices of young and old rats

1988 ◽  
Vol 46 ◽  
pp. 168
Author(s):  
Tadami Hokonohara ◽  
Yosiki Sinoda ◽  
Nobuaki Hori ◽  
Nobuo Katsuda
Keyword(s):  
Synaptic Plasticity ◽  
Piriform Cortex ◽  
Old Rats ◽  
Cortex Slices
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