The effect of medial thalamic lesions on previously established fear-motivated behaviour.

1963 ◽  
Vol 17 (2) ◽  
pp. 183-187 ◽  
Author(s):  
C. H. Vanderwolf
Keyword(s):  
Thalamic Lesions

Thalamic lesions produced by gamma thalamotomy for movement disorders

2002 ◽  
Vol 97 ◽  
pp. 600-606 ◽  
Author(s):  
Chihiro Ohye ◽  
Tohru Shibazaki ◽  
Jie Zhang ◽  
Yoshitaka Andou
Keyword(s):  
Mr Imaging ◽  
Involuntary Movement ◽  
Gamma Knife Radiosurgery ◽  
Target Point ◽  
High Signal ◽  
Thalamic Lesion ◽  
Content Type ◽  
Stereotactic Thalamotomy ◽  
Thalamic Lesions ◽  
Fine Print

Object. The treatment of Parkinson disease and other kinds of involuntary movement by gamma knife radiosurgery (GKS) is presented. This is an extension of previous work. The clinical course and thalamic lesions were the main factors examined. Methods. Seventeen new cases were added to the previously reported 36 cases. The course and results for the whole series of 53 patients were examined. Treatment was undertaken using a single 4-mm collimator shot to deliver 130 Gy to the target. The target was determined in the previously treated patients by using classic methods involved in conventional stereotactic thalamotomy with microrecording. More recently, target localization has been performed by relating the target point to the total length of the thalamus. Points may then be defined as percentages of that length measured from the anterior pole. Targets can then be determined in relationship to the appropriate percentage. Thirty-five patients have been followed for more than 2 years and the longest follow up was 8 years. Two kinds of thalamic lesion were seen after GKS. Volumetric analysis on MR imaging revealed that the larger lesion was 400 to 500 mm3 at the beginning and gradually decreased in size. The smaller lesion occupied approximately 200 mm3 and also shrank over several months. Eighty percent of the treated cases showed good results and no significant complications, with the tremor subsiding at 1 year (Type 1). Several cases deviated from this standard course in four different ways (Types 2–5). If tremor persisted, conventional stereotactic thalamotomy with microrecording was performed. During such operations, normal neuronal activity was recorded from the region adjacent to the GKS thalamotomy target. This was the region showing a high signal on MR imaging. The activity patterns included the rhythmical grouped discharge of tremor rhythm. Conclusions. Gamma thalamotomy for functional disorders is still under development, but because the results with careful target planning are satisfactory, there are grounds for increasing optimism.

scholarly journals Anterior thalamic lesions stop synaptic plasticity in retrosplenial cortex slices: expanding the pathology of diencephalic amnesia

Brain ◽  
2009 ◽  
Vol 132 (7) ◽  
pp. 1847-1857 ◽  
Author(s):  
D. L. F. Garden ◽  
P. V. Massey ◽  
D. A. Caruana ◽  
B. Johnson ◽  
E. C. Warburton ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Retrosplenial Cortex ◽  
Diencephalic Amnesia ◽  
Thalamic Lesions ◽  
Cortex Slices

Non-convulsive status epilepticus induced by acute thalamic lesions: a report of three cases

Seizure ◽  
2021 ◽  
Author(s):  
Sara Parreira ◽  
Luís Abreu ◽  
Ana Franco ◽  
Carla Bentes ◽  
Ana Rita Peralta
Keyword(s):  
Status Epilepticus ◽  
Convulsive Status Epilepticus ◽  
Thalamic Lesions

Robot-Aided Neuro-Rehabilitation in Stroke: Neuro-Recovery for Thalamic Lesion

1999 ◽  
Author(s):  
Hermano I. Krebs ◽  
Neville Hogan ◽  
Bruce Volpe ◽  
Mindy Aisen ◽  
Lisa Edelstein ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Information Technology ◽  
Clinical Trials ◽  
Video Games ◽  
Thalamic Lesion ◽  
The Novel ◽  
New Class ◽  
Rehabilitation Hospital ◽  
Thalamic Lesions ◽  
Interactive User

Abstract We are applying robotics and information technology to assist, enhance, and quantify neuro-rehabilitation. Our goal is a new class of interactive, user-affectionate clinical devices designed not only for evaluating patients, but also for delivering meaningful therapy via engaging “video games.” Notably, the novel robot MIT-MANUS has been designed and programmed for clinical neurological applications, and has undergone extensive clinical trials for more than four years at Burke Rehabilitation Hospital – White Plains, NY. This paper will review the main result of the pilot clinical trial of the 20 patients focusing on the consequences of thalamic lesions.

Heterogeneous pathological processes account for thalamic degeneration in multiple sclerosis: Insights from 7 T imaging

2017 ◽  
Vol 24 (11) ◽  
pp. 1433-1444 ◽  
Author(s):  
Céline Louapre ◽  
Sindhuja T Govindarajan ◽  
Costanza Giannì ◽  
Nancy Madigan ◽  
Jacob A Sloane ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Multiple Sclerosis ◽  
Lesion Volume ◽  
Thalamic Lesion ◽  
Cortical Lesions ◽  
Focal Lesions ◽  
Thalamic Degeneration ◽  
Relapsing Remitting ◽  
Thalamic Lesions ◽  
Magnetic Resonance Imaging Mri

Background: Thalamic degeneration impacts multiple sclerosis (MS) prognosis. Objective: To investigate heterogeneous thalamic pathology, its correlation with white matter (WM), cortical lesions and thickness, and as function of distance from cerebrospinal fluid (CSF). Methods: In 41 MS subjects and 17 controls, using 3 and 7 T imaging, we tested for (1) differences in thalamic volume and quantitative T2* (q-T2*) (2) globally and (3) within concentric bands originating from the CSF/thalamus interface; (4) the relation between thalamic, cortical, and WM metrics; and (5) the contribution of magnetic resonance imaging (MRI) metrics to clinical scores. We also assessed MS thalamic lesion distribution as a function of distance from CSF. Results: Thalamic lesions were mainly located next to the ventricles. Thalamic volume was decreased in MS versus controls ( p < 10−2); global q-T2* was longer in secondary progressive multiple sclerosis (SPMS) only ( p < 10−2), indicating myelin and/or iron loss. Thalamic atrophy and longer q-T2* correlated with WM lesion volume ( p < 0.01). In relapsing-remitting MS, q-T2* thalamic abnormalities were located next to the WM ( p < 0.01 (uncorrected), p = 0.09 (corrected)), while they were homogeneously distributed in SPMS. Cortical MRI metrics were the strongest predictors of clinical outcome. Conclusion: Heterogeneous pathological processes affect the thalamus in MS. While focal lesions are likely mainly driven by CSF-mediated factors, overall thalamic degeneration develops in association with WM lesions.

scholarly journals Bilateral enhancing thalamic lesions in a 10 year old boy: case report

1999 ◽  
Vol 66 (5) ◽  
pp. 633-635 ◽  
Author(s):  
W. C Olivero ◽  
P. Deshmukh ◽  
M. Gujrati
Keyword(s):  
Case Report ◽  
Thalamic Lesions

scholarly journals The effect of medial thalamic lesions on acquisition of a go, no-go, tone-light discrimination task

1975 ◽  
Vol 5 (6) ◽  
pp. 495-497 ◽  
Author(s):  
Larry W. Means ◽  
James H. Harrington ◽  
G. Thomas Miller
Keyword(s):  
Discrimination Task ◽  
Thalamic Lesions
Sign in / Sign up

Export Citation Format

Share Document