scholarly journals Diffusion tensor imaging with quantitative fibre tracking in HIV infection and alcoholism comorbidity: synergistic white matter damage

Brain ◽  
2006 ◽  
Vol 130 (1) ◽  
pp. 48-64 ◽  
Author(s):  
A. Pfefferbaum ◽  
M. J. Rosenbloom ◽  
E. Adalsteinsson ◽  
E. V. Sullivan
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Hiv Infection ◽  
Diffusion Tensor ◽  
White Matter Damage ◽  
Fibre Tracking

White-Matter Damage in Clade C HIV-Positive Subjects: A Diffusion Tensor Imaging Study

2011 ◽  
Vol 23 (3) ◽  
pp. 308-315 ◽  
Author(s):  
Jacqueline Hoare ◽  
Jean-Paul Fouche ◽  
Bruce Spottiswoode ◽  
Katherine Sorsdahl ◽  
Marc Combrinck ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Hiv Positive ◽  
White Matter Damage ◽  
Clade C ◽  
Diffusion Tensor Imaging Study

scholarly journals Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: A combined optical coherence tomography and diffusion tensor imaging study

2014 ◽  
Vol 20 (14) ◽  
pp. 1904-1907 ◽  
Author(s):  
Michael Scheel ◽  
Carsten Finke ◽  
Timm Oberwahrenbrock ◽  
Alina Freing ◽  
Luisa-Maria Pech ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Corpus Callosum ◽  
Layer Thickness ◽  
Diffusion Tensor ◽  
Retinal Nerve Fibre Layer ◽  
Optic Radiation ◽  
White Matter Damage ◽  
Nerve Fibre Layer

We investigated the association of retinal nerve fibre layer thickness (RNFL) with white matter damage assessed by diffusion tensor imaging (DTI). Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography. DTI was analysed with a voxel-based whole brain and region-based analysis of optic radiation, corpus callosum and further white matter. Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls. RNFL correlated with optic radiation FA, but also with corpus callosum and remaining white matter FA. Our findings demonstrate that RNFL changes indicate white matter damage exceeding the visual pathway.

End-Stage Renal Disease: In Vivo Diffusion-Tensor Imaging of Silent White Matter Damage

Radiology ◽  
2009 ◽  
Vol 252 (2) ◽  
pp. 518-525 ◽  
Author(s):  
Tsyh-Jyi Hsieh ◽  
Jer-Ming Chang ◽  
Hung-Yi Chuang ◽  
Chih-Hung Ko ◽  
Miao-Ling Hsieh ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Diffusion Tensor ◽  
White Matter Damage ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Cognitive ocular motor deficits and white matter damage chronically after sports-related concussion

2021 ◽  
Vol 3 (3) ◽  
Author(s):  
Georgia F Symons ◽  
Meaghan Clough ◽  
Steven Mutimer ◽  
Brendan P Major ◽  
William T O’Brien ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Cognitive Flexibility ◽  
Processing Speed ◽  
Switch Cost ◽  
Diffusion Tensor ◽  
Motor Deficits ◽  
Ocular Motor ◽  
White Matter Damage ◽  
History Of

Abstract A history of concussion has been linked to long-term cognitive deficits; however, the neural underpinnings of these abnormalities are poorly understood. This study recruited 26 asymptomatic male Australian footballers with a remote history of concussion (i.e. at least six months since last concussion), and 23 non-collision sport athlete controls with no history of concussion. Participants completed three ocular motor tasks (prosaccade, antisaccade and a cognitively complex switch task) to assess processing speed, inhibitory control and cognitive flexibility, respectively. Diffusion tensor imaging data were acquired using a 3 T MRI scanner, and analysed using tract-based spatial statistics, to investigate white matter abnormalities and how they relate to ocular motor performance. Australian footballers had significantly slower adjusted antisaccade latencies compared to controls (P = 0.035). A significant switch cost (i.e. switch trial error > repeat trial error) was also found on the switch task, with Australian footballers performing increased magnitude of errors on prosaccade switch trials relative to prosaccade repeat trials (P = 0.023). Diffusion tensor imaging analysis found decreased fractional anisotropy, a marker of white matter damage, in major white matter tracts (i.e. corpus callosum, corticospinal tract) in Australian footballers relative to controls. Notably, a larger prosaccade switch cost was significantly related to reduced fractional anisotropy in anterior white matter regions found to connect to the prefrontal cortex (i.e. a key cortical ocular motor centre involved in executive functioning and task switching). Taken together, Australian footballers with a history of concussion have ocular motor deficits indicative of poorer cognitive processing speed and cognitive flexibility, which are related to reduce white matter integrity in regions projecting to important cognitive ocular motor structures. These findings provide novel insights into the neural mechanisms that may underly chronic cognitive impairments in individuals with a history of concussion.

White matter damage on diffusion tensor imaging correlates with age-related cognitive decline

Neurology ◽  
2006 ◽  
Vol 66 (2) ◽  
pp. 217-222 ◽  
Author(s):  
R. A. Charlton ◽  
T. R. Barrick ◽  
D. J. McIntyre ◽  
Y. Shen ◽  
M. O'Sullivan ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Cognitive Decline ◽  
Diffusion Tensor ◽  
White Matter Damage ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Chronic cocaine administration causes extensive white matter damage in brain: Diffusion tensor imaging and immunohistochemistry studies

2014 ◽  
Vol 221 (3) ◽  
pp. 220-230 ◽  
Author(s):  
Ponnada A. Narayana ◽  
Juan J. Herrera ◽  
Kurt H. Bockhorst ◽  
Emilio Esparza-Coss ◽  
Ying Xia ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Damage ◽  
Cocaine Administration ◽  
Chronic Cocaine
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