scholarly journals Age-Related Changes in 11 -Hydroxysteroid Dehydrogenase Type 2 Activity in Normotensive Subjects

2013 ◽  
Vol 26 (4) ◽  
pp. 481-487 ◽  
Author(s):  
C. Campino ◽  
A. Martinez-Aguayo ◽  
R. Baudrand ◽  
C. A. Carvajal ◽  
M. Aglony ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Age Related ◽  
Normotensive Subjects ◽  
Age Related Changes

scholarly journals Age-related changes in the expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells.

2009 ◽  
Vol 47 (2) ◽  
Author(s):  
Yvetta Koeva ◽  
Mariana Bakalska ◽  
Nina Atanassova ◽  
Katerina Georgieva ◽  
Michail Davidoff
Keyword(s):  
Leydig Cells ◽  
Hydroxysteroid Dehydrogenase ◽  
Age Related ◽  
Age Related Changes

We-P11:23 Ace and PAI-1 insertion/deletion polymorphisms and age-related changes in pulse pressure in subjects with type 2 diabetes

2006 ◽  
Vol 7 (3) ◽  
pp. 350-351
Author(s):  
G. Penno ◽  
D. Lucchesi ◽  
L. Pucci ◽  
C. Fotino ◽  
S. Triscornia ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pulse Pressure ◽  
Age Related ◽  
Pai 1 ◽  
Age Related Changes

scholarly journals Dysregulation of adipose ILC2 underlies thermogenic failure in aging

2020 ◽  
Author(s):  
Emily L. Goldberg ◽  
Irina Shchukina ◽  
Yun-Hee Youm ◽  
Christina D. Camell ◽  
Tamara Dlugos ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Core Body Temperature ◽  
Lymphoid Cells ◽  
Adipose Tissue Inflammation ◽  
Age Related ◽  
Core Body ◽  
Old Mice ◽  
Functional Defects ◽  
Age Related Changes

AbstractAging impairs the integrated immunometabolic responses which have evolved to maintain core body temperature in homeotherms to survive cold-stress, infections, and dietary restriction. Adipose tissue inflammation regulates the thermogenic stress response but how adipose tissue-resident cells instigate thermogenic failure in aged are unknown. Here, we define alterations in the adipose-resident immune system and identify that type 2 innate lymphoid cells (ILC2) are lost in aging. Restoration of ILC2 numbers in aged mice to levels seen in adults through IL-33 supplementation failed to rescue old mice from metabolic impairment and cold-induced lethality. Transcriptomic analyses revealed intrinsic defects in aged ILC2, and adoptive transfer of adult ILC2 are sufficient to protect old mice against cold. Thus, the functional defects in adipose ILC2 during aging drive thermogenic failure.One Sentence SummaryAge-related changes in adipose tissue drive reprogramming of ILC2 that leads to impaired cold tolerance

scholarly journals Age-related changes in the diurnal variation of ketogenesis in patients with type 2 diabetes and relevance to hypoglycemic medications

2015 ◽  
Vol 62 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Hitomi Nakayama ◽  
Ichiro Tokubuchi ◽  
Nobuhiko Wada ◽  
Munehisa Tsuruta ◽  
Tsuyoshi Ohki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diurnal Variation ◽  
Age Related ◽  
Age Related Changes

scholarly journals Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2636 ◽  
Author(s):  
Leslie A. Consitt ◽  
Courtney Dudley ◽  
Gunjan Saxena
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Resistance Training ◽  
Glucose Metabolism ◽  
Age Related ◽  
Age Related Changes

Aging is associated with insulin resistance and the development of type 2 diabetes. While this process is multifaceted, age-related changes to skeletal muscle are expected to contribute to impaired glucose metabolism. Some of these changes include sarcopenia, impaired insulin signaling, and imbalances in glucose utilization. Endurance and resistance exercise training have been endorsed as interventions to improve glucose tolerance and whole-body insulin sensitivity in the elderly. While both types of exercise generally increase insulin sensitivity in older adults, the metabolic pathways through which this occurs can differ and can be dependent on preexisting conditions including obesity and type 2 diabetes. In this review, we will first highlight age-related changes to skeletal muscle which can contribute to insulin resistance, followed by a comparison of endurance and resistance training adaptations to insulin-stimulated glucose metabolism in older adults.

scholarly journals Age-Related Changes in Postprandial Plasma Glucose in Type 2 Diabetes

2000 ◽  
Vol 67 (4) ◽  
pp. 284-286
Author(s):  
Kenzo Oba ◽  
Yoshimasa Igari ◽  
Emiko Takai ◽  
Sachihito Soya ◽  
Noriaki Matsumura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Postprandial Plasma Glucose ◽  
Age Related ◽  
Age Related Changes
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