scholarly journals Age-Related Changes in Rat Hippocampal Theta Rhythms: A Difference between Type 1 and Type 2 Theta.

1999 ◽  
Vol 61 (5) ◽  
pp. 543-548 ◽  
Author(s):  
Yasuyuki Abe ◽  
Keiichiro Toyosawa
Keyword(s):  
Age Related ◽  
Hippocampal Theta ◽  
Age Related Changes

scholarly journals Changes in the OCT angiographic appearance of type 1 and type 2 CNV in exudative AMD during anti-VEGF treatment

2019 ◽  
Vol 4 (1) ◽  
pp. e000369 ◽  
Author(s):  
Henrik Faatz ◽  
Marie-Louise Farecki ◽  
Kai Rothaus ◽  
Matthias Gutfleisch ◽  
Daniel Pauleikhoff ◽  
...  
Keyword(s):  
Age Related Macular Degeneration ◽  
Fluid Distribution ◽  
Repeated Treatment ◽  
Foveal Thickness ◽  
Central Foveal Thickness ◽  
Anti Vegf ◽  
Age Related ◽  
Sd Oct

ObjectiveOptical coherence tomography angiography (OCT-A) enables detailed visualisation of the vascular structure of choroidal neovascularisation (CNV). The aim of this study was to determine whether mathematically ascertained OCT-A vascular parameters of type 1 and type 2 CNV in exudative age-related macular degeneration (AMD) change during antivascular endothelial growth factor (anti-VEGF) treatment. The OCT-A vascular parameters were also compared with previously obtained activity parameters (fluid distribution on spectral domain OCT (SD-OCT)) to establish whether they could potentially be used as further ‘activity parameters’ for assessment of anti-VEGF treatment.Methods and AnalysisWe evaluated 27 eyes of 27 patients (mean follow-up 9.8 months) with type 1, type 2 or mixed CNV who had received anti-VEGF treatment (IVAN scheme). The parameters analysed were area (aCNV), total length of all vessels (tlCNV), overall number of vascular segments (nsCNV) and fractal dimension (FD) of the CNV. The changes in each of these parameters were correlated with the central foveal thickness (CFT).ResultsRegression and renewed perfusion of the CNV corresponded with the decrease or increase, respectively, of macular fluid distribution on SD-OCT. The increase and decrease of CFT during anti-VEGF treatment were highly significantly correlated with changes in FD (p<0.00001), aCNV (p<0.00001), tlCNV (p<0.00001) and nsCNV (p<0.00001).ConclusionOCT-A enables detailed analysis of AMD with regard to FD, aCNV, tlCNV and nsCNV. As the changes in these parameters correlate closely with changes on SD-OCT, they can be used as new activity parameters, alongside fluid distribution, for assessment of treatment effect and as parameters of stabilisation or the need for repeated treatment.

We-P11:23 Ace and PAI-1 insertion/deletion polymorphisms and age-related changes in pulse pressure in subjects with type 2 diabetes

2006 ◽  
Vol 7 (3) ◽  
pp. 350-351
Author(s):  
G. Penno ◽  
D. Lucchesi ◽  
L. Pucci ◽  
C. Fotino ◽  
S. Triscornia ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pulse Pressure ◽  
Age Related ◽  
Pai 1 ◽  
Age Related Changes

scholarly journals Age-Related Changes in 11 -Hydroxysteroid Dehydrogenase Type 2 Activity in Normotensive Subjects

2013 ◽  
Vol 26 (4) ◽  
pp. 481-487 ◽  
Author(s):  
C. Campino ◽  
A. Martinez-Aguayo ◽  
R. Baudrand ◽  
C. A. Carvajal ◽  
M. Aglony ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Age Related ◽  
Normotensive Subjects ◽  
Age Related Changes

scholarly journals Analyses of the effects of persistent subretinal fluid on visual/anatomic outcomes according to the type of macular neovascularization during the relaxed treat-and-extend protocol in age-related macular degeneration patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kyung Tae Kim ◽  
Ju Byung Chae ◽  
Seungheon Lee ◽  
Eoi Jong Seo ◽  
Dong Yoon Kim
Keyword(s):  
Macular Degeneration ◽  
Subretinal Fluid ◽  
Age Related Macular Degeneration ◽  
Long Term Effects ◽  
Treat And Extend ◽  
Anti Vegf ◽  
Age Related ◽  
Treat And Extend Regimen

Abstract Background To analyze the long-term effects of persistent subretinal fluid (SRF) on visual/anatomic outcomes according to the type of macular neovascularization (MNV) during relaxed treat-and-extend regimen with anti-vascular endothelial growth factor (anti-VEGF) agents in age-related macular degeneration (AMD) patients. Methods Patients with fovea-involving type 1 or type 2 MNV, treated with a relaxed treat-and-extend regimen for 2 years were retrospectively reviewed. Eyes with SRF observed more than three times per year were defined as the ‘persistent SRF (+) group’. To exclude the effects of IRF as much as possible, the eyes with persistent IRF were excluded. The effects of persistent SRF on the best-corrected visual acuity (BCVA), central subfield retinal thickness (CST), and changes in the photoreceptor layer (PRL) thickness and outer retinal bands (external limiting membrane, ellipsoid zone, and cone outer segment tip line) after anti-VEGF injection were analyzed for each MNV type. Results Seventy-seven eyes with type 1 MNV (44 eyes with persistent SRF) and 53 eyes with type 2 MNV (18 eyes with persistent SRF) were enrolled. Following a relaxed treat-and-extend regimen with anti-VEGF agents, BCVA and CST improved for each MNV type. In comparison between persistent SRF (+) and persistent SRF (−) group, there were no differences in the amount of change in BCVA and CST between the two groups for each MNV type during 2-year follow-up periods. In addition, there were no differences in the amount of reduction in PRL thickness and state of the outer retinal bands between the two groups for each MNV type. Conclusions Using a relaxed treat-and-extend regimen with anti-VEGF agents, persistent SRF did not have additional effects on visual and anatomic outcomes by 2 years, regardless of the MNV type.

scholarly journals Dysregulation of adipose ILC2 underlies thermogenic failure in aging

2020 ◽  
Author(s):  
Emily L. Goldberg ◽  
Irina Shchukina ◽  
Yun-Hee Youm ◽  
Christina D. Camell ◽  
Tamara Dlugos ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Core Body Temperature ◽  
Lymphoid Cells ◽  
Adipose Tissue Inflammation ◽  
Age Related ◽  
Core Body ◽  
Old Mice ◽  
Functional Defects ◽  
Age Related Changes

AbstractAging impairs the integrated immunometabolic responses which have evolved to maintain core body temperature in homeotherms to survive cold-stress, infections, and dietary restriction. Adipose tissue inflammation regulates the thermogenic stress response but how adipose tissue-resident cells instigate thermogenic failure in aged are unknown. Here, we define alterations in the adipose-resident immune system and identify that type 2 innate lymphoid cells (ILC2) are lost in aging. Restoration of ILC2 numbers in aged mice to levels seen in adults through IL-33 supplementation failed to rescue old mice from metabolic impairment and cold-induced lethality. Transcriptomic analyses revealed intrinsic defects in aged ILC2, and adoptive transfer of adult ILC2 are sufficient to protect old mice against cold. Thus, the functional defects in adipose ILC2 during aging drive thermogenic failure.One Sentence SummaryAge-related changes in adipose tissue drive reprogramming of ILC2 that leads to impaired cold tolerance

scholarly journals Age-related changes in the diurnal variation of ketogenesis in patients with type 2 diabetes and relevance to hypoglycemic medications

2015 ◽  
Vol 62 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Hitomi Nakayama ◽  
Ichiro Tokubuchi ◽  
Nobuhiko Wada ◽  
Munehisa Tsuruta ◽  
Tsuyoshi Ohki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diurnal Variation ◽  
Age Related ◽  
Age Related Changes
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