scholarly journals Multiple Introductions of Dengue 2 Virus Strains into Saudi Arabia from 1992 to 2014

2016 ◽  
Vol 16 (6) ◽  
pp. 391-399 ◽  
Author(s):  
Sherif A. El-Kafrawy ◽  
Sayed S. Sohrab ◽  
Said Abol Ela ◽  
Adly M.M. Abd-Alla ◽  
Rowa Alhabbab ◽  
...  
Viruses ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 540
Author(s):  
Xin Chen ◽  
Dillon Charles Adam ◽  
Abrar Ahmad Chughtai ◽  
Sacha Stelzer-Braid ◽  
Matthew Scotch ◽  
...  

This study compared the phylogeography of MERS-CoV between hospital outbreak-associated cases and sporadic cases in Saudi Arabia. We collected complete genome sequences from human samples in Saudi Arabia and data on the multiple risk factors of human MERS-CoV in Saudi Arabia reported from 2012 to 2018. By matching each sequence to human cases, we identified isolates as hospital outbreak-associated cases or sporadic cases. We used Bayesian phylogenetic methods including temporal, discrete trait analysis and phylogeography to uncover transmission routes of MERS-CoV isolates between hospital outbreaks and sporadic cases. Of the 120 sequences collected between 19 June 2012 and 23 January 2017, there were 64 isolates from hospital outbreak-associated cases and 56 from sporadic cases. Overall, MERS-CoV is fast evolving at 7.43 × 10−4 substitutions per site per year. Isolates from hospital outbreaks showed unusually fast evolutionary speed in a shorter time-frame than sporadic cases. Multiple introductions of different MERS-CoV strains occurred in three separate hospital outbreaks. MERS-CoV appears to be mutating in humans. The impact of mutations on viruses transmissibility in humans is unknown.


2019 ◽  
Vol 16 (1) ◽  
Author(s):  
R. Tedjo Sasmono ◽  
Lily Pertiwi Kalalo ◽  
Suryani Trismiasih ◽  
Dionisius Denis ◽  
Benediktus Yohan ◽  
...  

2016 ◽  
Vol 45 ◽  
pp. 21
Author(s):  
S. Fagbo ◽  
L. Skakni ◽  
D.K. Chu ◽  
M. Garbati ◽  
M. Peiris ◽  
...  

2016 ◽  
Vol 49 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Mahmoud M. Ismail ◽  
Mahmoud H. A. Mohamed ◽  
Ibrahim M. El-Sabagh ◽  
Mohamed A. Al-Hammadi

2011 ◽  
Vol 92 (11) ◽  
pp. 2512-2522 ◽  
Author(s):  
Elena Sotelo ◽  
Jovita Fernández-Pinero ◽  
Francisco Llorente ◽  
Ana Vázquez ◽  
Ana Moreno ◽  
...  

In recent years, West Nile virus (WNV) has re-emerged in the Western Mediterranean region. As a result, the number of complete WNV genome sequences available from this region has increased, allowing more detailed phylogenetic analyses, which may help to understand the evolutionary history of WNV circulating in the Western Mediterranean. To this aim, the present work describes six new complete WNV sequences from recent outbreaks and surveillance in Italy in 2008–2009 and in Spain in 2008 and 2010. Comparison with other sequences from different WNV clusters within lineage 1 (clade 1a) confirmed that all Western Mediterranean WNV isolates obtained since 1996 (except one from Tunisia, collected in 1997) cluster in a single monophyletic group (here called ‘WMed’ subtype). The analysis differentiated two subgroups within this subtype, which appear to have evolved from earlier WMed strains, suggesting a single introduction in the area, and further dissemination and evolution. Close similarities between WNV variants circulating in consecutive years, one in Spain, between 2007 and 2008, and another in Italy between 2008 and 2009, suggest that the virus possibly overwinters in Western Mediterranean sites. The NS3249-proline genotype, recently proposed as a virulence determinant for WNV, has arisen independently at least twice in the area. Overall, these results indicate that the frequent recurrence of outbreaks caused by phylogenetically homogeneous WNV in the Western Mediterranean since 1996 is consistent with a single introduction followed by viral persistence in endemic foci in the area, rather than resulting from independent introductions from exogenous endemic foci.


Vacunas ◽  
2020 ◽  
Vol 21 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Y.M. AlGoraini ◽  
N.N. AlDujayn ◽  
M.A. AlRasheed ◽  
Y.E. Bashawri ◽  
S.S. Alsubaie ◽  
...  

2016 ◽  
Vol 22 ◽  
pp. 224
Author(s):  
Subodh Banzal ◽  
Sonal Banzal ◽  
Sadhana Banzal ◽  
Ayobenji Ayoola

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