Associations of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene Polymorphisms with Susceptibility to Graves' Disease in a Japanese Population

Thyroid ◽  
2008 ◽  
Vol 18 (6) ◽  
pp. 625-630 ◽  
Author(s):  
Michiko Ichimura ◽  
Hiroo Kaku ◽  
Tomoka Fukutani ◽  
Hirohisa Koga ◽  
Tokunori Mukai ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Japanese Population ◽  
Gene Polymorphisms ◽  
Tyrosine Phosphatase ◽  
Graves Disease ◽  
Ptpn22 Gene ◽  
Protein Tyrosine

scholarly journals Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo

2020 ◽  
Vol 15 ◽  
pp. 117727192090303
Author(s):  
Ghaleb Bin Huraib ◽  
Fahad Al Harthi ◽  
Misbahul Arfin ◽  
Abdulrahman Aljamal ◽  
Abdulqader Saeed Alrawi ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Amplification Refractory Mutation System ◽  
Functional Polymorphism ◽  
Ptpn22 Gene ◽  
Protein Tyrosine ◽  
Mutation System ◽  
Pcr Method ◽  
Polymerase Chain ◽  
Saudi Arabians

The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with susceptibility to autoimmune diseases. The functional polymorphism in PTPN22 at 1857 is a strong risk factor for vitiligo susceptibility in Europeans; however, controversy exits in other populations. Present study was aimed to determine whether the PTPN22 C1857T polymorphism confers susceptibility to vitiligo in Saudi Arabians. Genomic DNA was extracted and amplified using tetra primer amplification-refractory mutation system polymerase chain reaction (ARMS-PCR) method. The frequencies of allele T and genotype CT of PTPN22 C1858T polymorphism were significantly higher, whereas those of allele C and genotype CC were lower in patients as compared with controls ( P < 0.0001). The genotype TT was absent in both the patients and controls. It is concluded that PTPN22 C1858T polymorphism is strongly associated with vitiligo susceptibility. However, additional studies are warranted using large number of samples from different ethnicities and geographical areas.

Association of the Protein Tyrosine Phosphatase Nonreceptor 22 Haplotypes with Autoimmune Thyroid Disease in the Japanese Population

Thyroid ◽  
2010 ◽  
Vol 20 (8) ◽  
pp. 893-899 ◽  
Author(s):  
Yoshiyuki Ban ◽  
Teruaki Tozaki ◽  
Matsuo Taniyama ◽  
Yasuko Nakano ◽  
Yoshihisa Ban ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Thyroid Disease ◽  
Japanese Population ◽  
Autoimmune Thyroid Disease ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Autoimmune Thyroid

scholarly journals Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes

Diabetes ◽  
2004 ◽  
Vol 53 (11) ◽  
pp. 3007-3012 ◽  
Author(s):  
J. L. Bento ◽  
N. D. Palmer ◽  
J. C. Mychaleckyj ◽  
L. A. Lange ◽  
C. D. Langefeld ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Protein Tyrosine Phosphatase ◽  
Gene Polymorphisms ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine
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