Association of the Protein Tyrosine Phosphatase Nonreceptor 22 Haplotypes with Autoimmune Thyroid Disease in the Japanese Population

Thyroid ◽  
2010 ◽  
Vol 20 (8) ◽  
pp. 893-899 ◽  
Author(s):  
Yoshiyuki Ban ◽  
Teruaki Tozaki ◽  
Matsuo Taniyama ◽  
Yasuko Nakano ◽  
Yoshihisa Ban ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Thyroid Disease ◽  
Japanese Population ◽  
Autoimmune Thyroid Disease ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Autoimmune Thyroid

R620W polymorphism of protein tyrosine phosphatase PTPN22 in Egyptian children and adolescents with systemic lupus erythematosus: relation to thyroid autoimmunity

2013 ◽  
Vol 25 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Rasha Tarif Hamza ◽  
Khaled S. Awwad ◽  
Khaled A. Temsah ◽  
Amira I. Hamed
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Protein Tyrosine Phosphatase ◽  
Lupus Erythematosus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Tyrosine Phosphatase ◽  
Systemic Lupus ◽  
Protein Tyrosine ◽  
Autoimmune Thyroid

Abstract Background: Some studies showed associations of the minor T allele of the C1858T single nucleotide polymorphism (SNP) corresponding to the R620W amino acid substitution of protein tyrosine phosphatase (PTPN22) with multiple autoimmune diseases, including systemic lupus erythematosus (SLE). Objectives: To study the frequency of PTPN22 R620W polymorphism among Egyptian patients with SLE and to test the association of the T allele with autoimmune thyroid disease in such patients. Methods: Clinical evaluation, measurement of thyroid hormones and antibodies, and genotyping of PTPN22 R620W polymorphism were done for 60 SLE patients and 60 age- and sex-matched healthy subjects. Results: Nineteen SLE cases (31.67%) had thyroid dysfunction with subclinical hypothyroidism being the most frequent form of thyroid dysfunction (20%) followed by primary hypothyroidism (6.67%), subclinical hyperthyroidism (3.33%) and primary hyperthyroidism (1.67%). Autoimmune thyroid disease was detected in 36.67% of cases. Systemic lupus erythematosus disease activity index (SLEDAI) score did not differ between patients with thyroid dysfunction and euthyroid patients (p=0.061) nor with the frequency of positive thyroid peroxidise antibodies (TPOAb, p=0.092) and antithyroglobulin antibodies (ATGAb, p=0.1). T allele frequency did not differ between cases and controls (p=1.19) and was associated with autoimmune thyroid disease in Egyptian SLE patients (p=0.002). Conclusions: R620W polymorphism of the PTPN22 gene is not a major risk allele for SLE susceptibility among Egyptian SLE patients but appears to be a risk factor for concurrent autoimmune thyroid disease and SLE.

Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population

Autoimmunity ◽  
2009 ◽  
Vol 42 (2) ◽  
pp. 126-130 ◽  
Author(s):  
Yoshiyuki Ban ◽  
Teruaki Tozaki ◽  
Matsuo Taniyama ◽  
Yasuko Nakano ◽  
Kei-Ichiro Yoneyama ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Japanese Population ◽  
Autoimmune Thyroid Disease ◽  
Association Studies ◽  
Autoimmune Thyroid

scholarly journals Multiple SNPs in Intron 41 of Thyroglobulin Gene Are Associated with Autoimmune Thyroid Disease in the Japanese Population

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e37501 ◽  
Author(s):  
Yoshiyuki Ban ◽  
Teruaki Tozaki ◽  
Matsuo Taniyama ◽  
Luce Skrabanek ◽  
Yasuko Nakano ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Japanese Population ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid ◽  
Multiple Snps ◽  
Thyroglobulin Gene

scholarly journals Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

2020 ◽  
Vol 11 ◽  
pp. 204201882095832
Author(s):  
Liyan Li ◽  
Shudong Liu ◽  
Junxia Yu
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Current Knowledge ◽  
Tyrosine Phosphatase ◽  
Autoimmune Thyroid

Autoimmune thyroid disease (AITD) and type 1 diabetes mellitus (T1DM) are two common autoimmune diseases that can occur concomitantly. In general, patients with diabetes have a high risk of AITD. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. In this paper, we summarize current knowledge in the field regarding potential pathogenic factors of T1DM and AITD, including human leukocyte antigen, autoimmune regulator, lymphoid protein tyrosine phosphatase, forkhead box protein P3, cytotoxic T lymphocyte-associated antigen, infection, vitamin D deficiency, and chemokine (C-X-C motif) ligand. These findings offer an insight into future immunotherapy for autoimmune diseases.

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