scholarly journals Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene single nucleotide polymorphisms and its interaction with T2DM on pulmonary tuberculosis in Chinese Uygur population

Oncotarget ◽  
2017 ◽  
Vol 8 (39) ◽  
pp. 65601-65608
Author(s):  
Xian-Hua Wang ◽  
Ai-Guo Ma ◽  
Xiu-Xia Han ◽  
Lei Chen ◽  
Hui Liang ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Pulmonary Tuberculosis ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Nucleotide Polymorphisms ◽  
Ptpn22 Gene ◽  
Single Nucleotide ◽  
Protein Tyrosine ◽  
Uygur Population

scholarly journals Association of PTPN22 single nucleotide polymorphisms with chronic spontaneous urticaria

2021 ◽  
Vol 49 (2) ◽  
pp. 40-45
Author(s):  
Maryam Sadr ◽  
Neda Khalili ◽  
Bahareh Mohebbi ◽  
Banafsheh Mosharmovahed ◽  
Parivash Afradi ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Haplotype Analysis ◽  
Tyrosine Phosphatase ◽  
Chronic Spontaneous Urticaria ◽  
Nucleotide Polymorphisms ◽  
Contributing Factors ◽  
Ptpn22 Gene ◽  
Single Nucleotide ◽  
Potential Association ◽  
Increased Susceptibility

Introduction and objectives: Chronic spontaneous urticaria (CSU) is thought to be an auto-immune disease in a subpopulation of patients. Protein tyrosine phosphatase-22 (PTPN22) polymorphisms are considered to be one of the strongest contributing factors to autoimmune diseases. In this study, we aimed to investigate the potential association of several PTPN22 single nucleotide polymorphisms (SNPs) with CSU in an Iranian population.Material and methods: A total of 93 CSU patients and 100 healthy individuals were included in this study. Five SNPs within the PTPN22 gene were analyzed using TaqMan genotyping assays. The frequency of alleles, genotypes, and haplotypes of PTPN22 SNPs (rs12760457, rs2476601, rs1310182, rs1217414, and rs33996649) was investigated.Results: A significantly higher prevalence of the rs1310182 T allele was observed among patients compared with controls [OR = 1.75 (95% CI: 1.17–2.63); P = 0.007]. In addition, the rs1310182 CC genotype and TT genotype were 0.47 and 2.06 times more common in patients, respectively (P = 0.03). Moreover, haplotype analysis demonstrated that CGCGC, CGTGC, and TGCGC (P < 0.001) were significantly associated with CSU. No significant differences were observed between the patients and controls in the other analyzed PTPN22 SNPs.Conclusions: Polymorphisms of the PTPN22 gene are associated with an increased susceptibility to CSU in the studied Iranian population.

scholarly journals Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo

2020 ◽  
Vol 15 ◽  
pp. 117727192090303
Author(s):  
Ghaleb Bin Huraib ◽  
Fahad Al Harthi ◽  
Misbahul Arfin ◽  
Abdulrahman Aljamal ◽  
Abdulqader Saeed Alrawi ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Amplification Refractory Mutation System ◽  
Functional Polymorphism ◽  
Ptpn22 Gene ◽  
Protein Tyrosine ◽  
Mutation System ◽  
Pcr Method ◽  
Polymerase Chain ◽  
Saudi Arabians

The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with susceptibility to autoimmune diseases. The functional polymorphism in PTPN22 at 1857 is a strong risk factor for vitiligo susceptibility in Europeans; however, controversy exits in other populations. Present study was aimed to determine whether the PTPN22 C1857T polymorphism confers susceptibility to vitiligo in Saudi Arabians. Genomic DNA was extracted and amplified using tetra primer amplification-refractory mutation system polymerase chain reaction (ARMS-PCR) method. The frequencies of allele T and genotype CT of PTPN22 C1858T polymorphism were significantly higher, whereas those of allele C and genotype CC were lower in patients as compared with controls ( P < 0.0001). The genotype TT was absent in both the patients and controls. It is concluded that PTPN22 C1858T polymorphism is strongly associated with vitiligo susceptibility. However, additional studies are warranted using large number of samples from different ethnicities and geographical areas.

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