scholarly journals Fast-Degradable Microbeads Encapsulating Human Umbilical Cord Stem Cells in Alginate for Muscle Tissue Engineering

2012 ◽  
Vol 18 (21-22) ◽  
pp. 2303-2314 ◽  
Author(s):  
Jun Liu ◽  
Hongzhi Zhou ◽  
Michael D. Weir ◽  
Hockin H.K. Xu ◽  
Qianming Chen ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Umbilical Cord ◽  
Muscle Tissue ◽  
Human Umbilical Cord ◽  
Umbilical Cord Stem Cells

Microbial stresses on human umbilical cord stem cells

2020 ◽  
Vol 15 ◽  
Author(s):  
Didem Kart ◽  
Betül Çelebi-Saltik
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Umbilical Cord ◽  
Bacterial Load ◽  
Early Period ◽  
Stress Factors ◽  
Human Umbilical Cord ◽  
Antibacterial Effects ◽  
Hematopoietic Stem ◽  
Umbilical Cord Stem Cells

: Umbilical cord and cord blood are acceptable as attractive sources of mesenchymal and hematopoietic stem cells, since their collection is non-invasive, painless, and does not evoke the ethical concerns. Microorganism-stem cell interaction plays an important role in stem cell self-renewal, differentiation, secretion profile and death. In the literature, few researchers are examining the relationship between pathogenic and commensal bacteria with umbilical cord-derived Mesenchymal Stem Cells (MSCs). These relationships vary depending on the bacterial load and the presence of the immune cell in the environment. Several bacterial pathogens act in the regenerative capacity of MSCs by changing their phenotype, development and viability due to several stress factors that are created by a microorganism such as hypoxia, oxidative stress, etc. On the other hand, the anti-inflammatory and antibacterial effects of MSCs were shown and these phenomena increased when the number of bacteria was high but decreased in the presence of low amounts of bacteria. The antibacterial effects of MSCs increased in the early period of infection, while their effects were decreased in the late period with high inflammatory response and bacterial load. In this review, we discussed the microbial stresses on human umbilical cord stem cells.

scholarly journals Gas-Foaming Calcium Phosphate Cement Scaffold Encapsulating Human Umbilical Cord Stem Cells

2012 ◽  
Vol 18 (7-8) ◽  
pp. 816-827 ◽  
Author(s):  
Wenchuan Chen ◽  
Hongzhi Zhou ◽  
Minghui Tang ◽  
Michael D. Weir ◽  
Chongyun Bao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Calcium Phosphate ◽  
Umbilical Cord ◽  
Calcium Phosphate Cement ◽  
Human Umbilical Cord ◽  
Umbilical Cord Stem Cells ◽  
Gas Foaming

Expression of epithelial markers by human umbilical cord stem cells. A topographical analysis

Placenta ◽  
2014 ◽  
Vol 35 (12) ◽  
pp. 994-1000 ◽  
Author(s):  
I. Garzón ◽  
C.A. Alfonso-Rodríguez ◽  
C. Martínez-Gómez ◽  
V. Carriel ◽  
M.A. Martin-Piedra ◽  
...  
Keyword(s):  
Stem Cells ◽  
Umbilical Cord ◽  
Human Umbilical Cord ◽  
Epithelial Markers ◽  
Umbilical Cord Stem Cells ◽  
Topographical Analysis

scholarly journals Human umbilical cord stem cells – the discovery, history and possible application

2020 ◽  
Vol 8 (2) ◽  
pp. 78-82
Author(s):  
Katarzyna Stefańska ◽  
Rut Bryl ◽  
Greg Hutchings ◽  
Jamil A. Shibli ◽  
Marta Dyszkiewicz-Konwińska
Keyword(s):  
Stem Cells ◽  
Umbilical Cord ◽  
Cellular Therapy ◽  
Umbilical Vein ◽  
Embryonic Stem ◽  
Experimental Medicine ◽  
Human Umbilical Cord ◽  
History Of ◽  
Umbilical Cord Stem Cells ◽  
Umbilical Cords

AbstractStem cells are now one of the most extensively studied fields in experimental medicine. Although embryonic stem cells (ESCs) have the capability to differentiate into lineages derived from all three primary germ layers, their use remains ethically controversial. Mesenchymal stromal cells’ (MSCs) utilization is not burdened with such concerns. MSCs were primarily characterized as fibroblastic cells from bone marrow stroma, with the ability to adhere to plastic and form clonogenic colonies (CFU-Fs – colony-forming unit-fibroblasts). Subsequent studies led to their isolation from various other adult or perinatal tissues, including the umbilical cord. Although in most cases MSCs are obtained from umbilical cords’ stroma (Wharton’s jelly), it has been demonstrated that both cord’s lining and endothelial layer of umbilical vein possess the cells that fulfill the minimal criteria for MSCs published in 2006 by the International Society for Cellular Therapy. Since the initial discovery, a number of pre-clinical and clinical studies were conducted with the use of MSCs derived from umbilical cords, targeting diseases such as cancer or autoimmune diseases. Moreover, their secretome may be even more beneficial, providing an opportunity to create cell-free therapies.Running title: The history of human umbilical cord stem cells

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