Human Umbilical Cord Stem Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Immunoinflammation and Remyelination

2013 ◽  
Vol 22 (7) ◽  
pp. 1053-1062 ◽  
Author(s):  
Rong Liu ◽  
Zhuo Zhang ◽  
Zhengjuan Lu ◽  
Cesar Borlongan ◽  
Jie Pan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Umbilical Cord ◽  
Human Umbilical Cord ◽  
Autoimmune Encephalomyelitis ◽  
Umbilical Cord Stem Cells ◽  
Experimental Autoimmune

Microbial stresses on human umbilical cord stem cells

2020 ◽  
Vol 15 ◽  
Author(s):  
Didem Kart ◽  
Betül Çelebi-Saltik
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Umbilical Cord ◽  
Bacterial Load ◽  
Early Period ◽  
Stress Factors ◽  
Human Umbilical Cord ◽  
Antibacterial Effects ◽  
Hematopoietic Stem ◽  
Umbilical Cord Stem Cells

: Umbilical cord and cord blood are acceptable as attractive sources of mesenchymal and hematopoietic stem cells, since their collection is non-invasive, painless, and does not evoke the ethical concerns. Microorganism-stem cell interaction plays an important role in stem cell self-renewal, differentiation, secretion profile and death. In the literature, few researchers are examining the relationship between pathogenic and commensal bacteria with umbilical cord-derived Mesenchymal Stem Cells (MSCs). These relationships vary depending on the bacterial load and the presence of the immune cell in the environment. Several bacterial pathogens act in the regenerative capacity of MSCs by changing their phenotype, development and viability due to several stress factors that are created by a microorganism such as hypoxia, oxidative stress, etc. On the other hand, the anti-inflammatory and antibacterial effects of MSCs were shown and these phenomena increased when the number of bacteria was high but decreased in the presence of low amounts of bacteria. The antibacterial effects of MSCs increased in the early period of infection, while their effects were decreased in the late period with high inflammatory response and bacterial load. In this review, we discussed the microbial stresses on human umbilical cord stem cells.

scholarly journals Neuroprotection and Immunomodulation With Mesenchymal Stem Cells in Chronic Experimental Autoimmune Encephalomyelitis

2008 ◽  
Vol 65 (6) ◽  
Author(s):  
Ibrahim Kassis ◽  
Nikolaos Grigoriadis ◽  
Basan Gowda-Kurkalli ◽  
Rachel Mizrachi-Kol ◽  
Tamir Ben-Hur ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Gas-Foaming Calcium Phosphate Cement Scaffold Encapsulating Human Umbilical Cord Stem Cells

2012 ◽  
Vol 18 (7-8) ◽  
pp. 816-827 ◽  
Author(s):  
Wenchuan Chen ◽  
Hongzhi Zhou ◽  
Minghui Tang ◽  
Michael D. Weir ◽  
Chongyun Bao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Calcium Phosphate ◽  
Umbilical Cord ◽  
Calcium Phosphate Cement ◽  
Human Umbilical Cord ◽  
Umbilical Cord Stem Cells ◽  
Gas Foaming
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