Characterization of a Novel Polymeric Scaffold for Potential Application in Tendon/Ligament Tissue Engineering

2006 ◽  
Vol 0 (0) ◽  
pp. 060118075515005 ◽  
Author(s):  
S. Sahoo ◽  
H. Ouyang ◽  
James C.-H. Goh ◽  
T.E. Tay ◽  
S.L. Toh
2006 ◽  
Vol 12 (1) ◽  
pp. 91-99 ◽  
Author(s):  
S. Sahoo ◽  
H. Ouyang ◽  
James C.-H. Goh ◽  
T.E. Tay ◽  
S.L. Toh

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Daniel Aparecido Lopes Vieira da Cunha ◽  
Paulo Inforçatti Neto ◽  
Kelli Cristina Micocci ◽  
Caroline Faria Bellani ◽  
Heloisa Sobreiro Selistre-de-Araujo ◽  
...  

Scaffolds of poly(ε-caprolactone) (PCL) and their biocomposites with 0, 1, 3, and 5 wt.% Biosilicate® were fabricated by the generative manufacturing process coupled with a vertical miniscrew extrusion head to application for restoration of bone tissue. Their morphological characterization indicated the designed 0°/90° architecture range of pore sizes and their interconnectivity is feasible for tissue engineering applications. Mechanical compression tests revealed an up to 57% increase in the stiffness of the scaffold structures with the addition of 1 to 5 wt.% Biosilicate® to the biocomposite. No toxicity was detected in the scaffolds tested by in vitro cell viability with MC3T3-E1 preosteoblast cell line. The results highlighted the potential application of scaffolds fabricated with poly(ε-caprolactone)/Biosilicate® to tissue engineering.


2020 ◽  
Vol 108 (6) ◽  
pp. 2546-2559 ◽  
Author(s):  
Diana Gabriela Soares ◽  
Ester Alves Ferreira Bordini ◽  
Fernanda Balestrero Cassiano ◽  
Erika Soares Bronze‐Uhle ◽  
Leandro Edgar Pacheco ◽  
...  

2009 ◽  
Vol 9999A ◽  
pp. NA-NA ◽  
Author(s):  
James W. S. Hayami ◽  
Denver C. Surrao ◽  
Stephen D. Waldman ◽  
Brian G. Amsden

2017 ◽  
Author(s):  
◽  
K. Maldonado-Lara

The Present work describes the preparation of nanocomposites based on chitosan (QS)/copper nanoparticles (nCu) with antibacterial properties and potential application in tissue engineering. For this purpose, nanocomposites were prepared by solution blending with ultrasound assisted, aiming to increase the nanoparticles dispersion in the biopolymer. FTIR analyses demonstrates that nCu supported in QS increase their interaction of nanoparticles with amine/hydroxyl groups of QS molecule. UV-Vis analyses demonstrates that QS/nCu nanocomposites have an absorption signal associated with the presence of nanoparticles and the possible Cu2+ ions release in liquid media. AFM analyses shown that hydrated QS form a mesh with micro pores, improving the bacterial penetration and the direct contact with nCu. This behavior was corroborated by antibacterial assays, where QS/nCu nanocomposites shown an antibacterial activity higher than 90% between 90-180 minutes of interaction. Our results suggest that is possible to obtain combined antibacterial/biocompatible nanomaterials with potential application in tissue engineering.


2017 ◽  
Vol 78 ◽  
pp. 787-795 ◽  
Author(s):  
Rui C.G. Coelho ◽  
Ana L.P. Marques ◽  
Sara M. Oliveira ◽  
Gabriela S. Diogo ◽  
Rogério P. Pirraco ◽  
...  

2017 ◽  
Author(s):  
◽  
K. Maldonado-Lara

The Present work describes the preparation of nanocomposites based on chitosan (QS)/copper nanoparticles (nCu) with antibacterial properties and potential application in tissue engineering. For this purpose, nanocomposites were prepared by solution blending with ultrasound assisted, aiming to increase the nanoparticles dispersion in the biopolymer. FTIR analyses demonstrates that nCu supported in QS increase their interaction of nanoparticles with amine/hydroxyl groups of QS molecule. UV-Vis analyses demonstrates that QS/nCu nanocomposites have an absorption signal associated with the presence of nanoparticles and the possible Cu2+ ions release in liquid media. AFM analyses shown that hydrated QS form a mesh with micro pores, improving the bacterial penetration and the direct contact with nCu. This behavior was corroborated by antibacterial assays, where QS/nCu nanocomposites shown an antibacterial activity higher than 90% between 90-180 minutes of interaction. Our results suggest that is possible to obtain combined antibacterial/biocompatible nanomaterials with potential application in tissue engineering.


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