Hyaluronan Hydrogels for the Local Delivery of Mesenchymal Stromal Cells to the Injured Vocal Fold

2019 ◽  
Vol 28 (17) ◽  
pp. 1177-1190 ◽  
Author(s):  
Stellan Hertegård ◽  
Srinivasa Rao Nagubothu ◽  
Emma Malmström ◽  
Cecilia E. Ström ◽  
Anna Tolf ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Vocal Fold ◽  
Local Delivery

Mesenchymal stromal cells modulate tissue repair responses within the injured vocal fold

2019 ◽  
Vol 130 (1) ◽  
Author(s):  
Srinivasa Rao Nagubothu ◽  
Rachael V. Sugars ◽  
Nikolce Tudzarovski ◽  
Anton Törnqvist Andrén ◽  
Matteo Bottai ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Tissue Repair ◽  
Vocal Fold

scholarly journals The Response of Vocal Fold Fibroblasts and Mesenchymal Stromal Cells to Vibration

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e30965 ◽  
Author(s):  
Joel Gaston ◽  
Beatriz Quinchia Rios ◽  
Rebecca Bartlett ◽  
Craig Berchtold ◽  
Susan L. Thibeault
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Vocal Fold

scholarly journals Adipose-derived mesenchymal stromal cells prevented rat vocal fold scarring

2017 ◽  
Vol 128 (1) ◽  
pp. E33-E40 ◽  
Author(s):  
Tsuyoshi Morisaki ◽  
Yo Kishimoto ◽  
Ichiro Tateya ◽  
Yoshitaka Kawai ◽  
Ryo Suzuki ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Vocal Fold

scholarly journals Mechanotransduction of vocal fold fibroblasts and mesenchymal stromal cells in the context of the vocal fold mechanome

2019 ◽  
Vol 83 ◽  
pp. 227-234 ◽  
Author(s):  
Rebecca S. Bartlett ◽  
Joel D. Gaston ◽  
Shuyun Ye ◽  
Christina Kendziorski ◽  
Susan L. Thibeault
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Vocal Fold

scholarly journals Adipose-Derived Mesenchymal Stromal Cells Persist in Tissue-Engineered Vocal Fold Replacement in Rabbits

2018 ◽  
Vol 127 (12) ◽  
pp. 962-968 ◽  
Author(s):  
Alexander N. Goel ◽  
Bhavani S. Gowda ◽  
Mysore S. Veena ◽  
Travis L. Shiba ◽  
Jennifer L. Long
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Vocal Fold ◽  
Rabbit Model ◽  
Cell Activity ◽  
Vocal Folds ◽  
Fibrin Gel ◽  
Cell Therapies ◽  
3 Dimensional ◽  
Adipose Derived Stromal Cells

Objectives: Cell therapies using mesenchymal stromal cells (MSCs) have been proposed as a promising new tool for the treatment of vocal fold scarring. However, the mechanisms by which MSCs promote healing as well as their duration of survival within the host vocal fold have yet to be defined. The aim of this work was to assess the persistence of embedded MSCs within a tissue-engineered vocal fold mucosal replacement in a rabbit model of vocal fold injury. Methods: Male rabbit adipose-derived MSCs were embedded within a 3-dimensional fibrin gel, forming the cell-based outer vocal fold replacement. Four female rabbits underwent unilateral resection of vocal fold epithelium and lamina propria and reconstruction with cell-based outer vocal fold replacement implantation. Polymerase chain reaction and fluorescent in situ hybridization for the sex-determining region of the Y chromosome (SRY-II) in the sex-mismatched donor-recipient pairs sought persistent cells after 4 weeks. Results: A subset of implanted male cells was detected in the implant site at 4 weeks. Many SRY-II-negative cells were also detected at the implant site, presumably representing native female cells that migrated to the area. No SRY-II signal was detected in contralateral control vocal folds. Conclusions: The emergent tissue after implantation of a tissue-engineered outer vocal fold replacement is derived both from initially embedded adipose-derived stromal cells and infiltrating native cells. Our results suggest this tissue-engineering approach can provide a well-integrated tissue graft with prolonged cell activity for repair of severe vocal fold scars.

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