scholarly journals The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease

2012 ◽  
Vol 15 (5) ◽  
pp. 483-494 ◽  
Author(s):  
Adiv A. Johnson ◽  
Kemal Akman ◽  
Stuart R.G. Calimport ◽  
Daniel Wuttke ◽  
Alexandra Stolzing ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Related Disease ◽  
Age Related

PHYSICAL ACTIVITY AS HEALTHY INTERVENTION AGAINST SEVERE OXIDATIVE STRESS IN ELDERLY POPULATION

2013 ◽  
pp. 1-9
Author(s):  
C. TOMAS-ZAPICO ◽  
E. IGLESIAS-GUTIERREZ ◽  
B. FERNANDEZ-GARCIA ◽  
D. DE GONZALO-CALVO
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Elderly Population ◽  
Physiological Basis ◽  
Related Disease ◽  
Age Related ◽  
Wide Range ◽  
Health Related ◽  
Relevant Risk Factor

Severe oxidative stress is a relevant risk factor for major deleterious health-related events in olderpeople and is thought to be an important contributor to age-related disease. Literature has suggested oxidativestress as a therapeutic target for mitigating the biological decline and attenuating the occurrence of adverseclinical events in aged individuals. However, definitive treatments are not known. Regular and moderate physicalactivity has been proposed as possible intervention for slowing age-related decline. This healthy strategy presentsa wide range of beneficial aspects for elderly, from the reduction of morbidity, disability, frailty and mortalityrates to treatment of many age-related disorders. Importantly, the global benefits on health are not shared by anyother strategies. Nevertheless, the physiological basis by which exercise produces its benefits to the organism isnot fully understood. This review summarizes the evidence for the role of physical activity as potential healthyintervention for mitigating the negative aspects of aging through the modulation of the oxidative mechanisms.

scholarly journals A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120388 ◽  
Author(s):  
Fu-Hui Xiao ◽  
Yong-Han He ◽  
Qi-Gang Li ◽  
Huan Wu ◽  
Long-Hai Luo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Human Longevity ◽  
Disease Genes ◽  
Related Disease ◽  
Age Related ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Scan

scholarly journals The Role of Macromolecular Damage in Aging and Age-related Disease

2014 ◽  
Vol 69 (Suppl 1) ◽  
pp. S28-S32 ◽  
Author(s):  
A. G. Richardson ◽  
E. E. Schadt
Keyword(s):  
Related Disease ◽  
Age Related ◽  
Macromolecular Damage

scholarly journals Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease

2020 ◽  
Vol 40 (11) ◽  
Author(s):  
Amy E. Morgan ◽  
Katie D. Acutt ◽  
Mark T. Mc Auley
Keyword(s):  
Dna Methylation ◽  
Methylation Status ◽  
Gene Promoter ◽  
Gene Promoters ◽  
Developmental Genes ◽  
Transfer Resistance ◽  
Related Disease ◽  
Age Related ◽  
Electrochemical Approach ◽  
The Future

Abstract There is a growing need for biomarkers which predict age-onset pathology. Although this is challenging, the methylome offers significant potential. Cancer is associated with the hypermethylation of many gene promoters, among which are developmental genes. Evolutionary theory suggests developmental genes arbitrate early-late life trade-offs, causing epimutations that increase disease vulnerability. Such genes could predict age-related disease. The aim of this work was to optimise an electrochemical procedure for the future investigation of a broad range of ageing-related pathologies. An electrochemical approach, which adopted three analytical techniques, was used to investigate DNA methylation in the engrailed-1 (EN1) gene promoter. Using synthetic single-stranded DNA, one technique was able to detect DNA at concentrations as low as 10 nM, with methylation status distinguishable at concentrations >25 nM. A negative correlation could be observed between % methylation of a heterogeneous solution and the key electrochemical parameter, charge transfer resistance (Rct; r = −0.982, P<0.01). The technique was applied to the breast cancer cell line Michigan Cancer Foundation-7 (MCF-7), where a similar correlation was observed (r = −0.965, P<0.01). These results suggest electrochemistry can effectively measure DNA methylation at low concentrations of DNA. This has implications for the future detection of age-related disease.

scholarly journals Role of PAPP-A in aging and age-related disease

2013 ◽  
Vol 48 (7) ◽  
pp. 612-613 ◽  
Author(s):  
Cheryl A. Conover
Keyword(s):  
Related Disease ◽  
Age Related

scholarly journals Nutritional influences on epigenetics and age-related disease

2011 ◽  
Vol 71 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Lara K. Park ◽  
Simonetta Friso ◽  
Sang-Woon Choi
Keyword(s):  
Dna Methylation ◽  
Histone Modifications ◽  
Healthy Aging ◽  
Vitamin B ◽  
Related Disease ◽  
Age Related ◽  
Nutritional Influences ◽  
One Carbon Metabolism ◽  
Epigenetic Patterns ◽  
Future Work

Nutritional epigenetics has emerged as a novel mechanism underlying gene–diet interactions, further elucidating the modulatory role of nutrition in aging and age-related disease development. Epigenetics is defined as a heritable modification to the DNA that regulates chromosome architecture and modulates gene expression without changes in the underlying bp sequence, ultimately determining phenotype from genotype. DNA methylation and post-translational histone modifications are classical levels of epigenetic regulation. Epigenetic phenomena are critical from embryonic development through the aging process, with aberrations in epigenetic patterns emerging as aetiological mechanisms in many age-related diseases such as cancer, CVD and neurodegenerative disorders. Nutrients can act as the source of epigenetic modifications and can regulate the placement of these modifications. Nutrients involved in one-carbon metabolism, namely folate, vitamin B12, vitamin B6, riboflavin, methionine, choline and betaine, are involved in DNA methylation by regulating levels of the universal methyl donor S-adenosylmethionine and methyltransferase inhibitor S-adenosylhomocysteine. Other nutrients and bioactive food components such as retinoic acid, resveratrol, curcumin, sulforaphane and tea polyphenols can modulate epigenetic patterns by altering the levels of S-adenosylmethionine and S-adenosylhomocysteine or directing the enzymes that catalyse DNA methylation and histone modifications. Aging and age-related diseases are associated with profound changes in epigenetic patterns, though it is not yet known whether these changes are programmatic or stochastic in nature. Future work in this field seeks to characterise the epigenetic pattern of healthy aging to ultimately identify nutritional measures to achieve this pattern.

scholarly journals Current Understanding of DNA Methylation and Age-related Disease

2018 ◽  
Vol 2 (2) ◽  
pp. 1-1 ◽  
Author(s):  
Eunise M. Aquino ◽  
◽  
Miles C. Benton ◽  
Larisa M. Haupt ◽  
Heidi G. Sutherland ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Current Understanding ◽  
Related Disease ◽  
Age Related
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