scholarly journals The role of lipid metabolism in aging, lifespan regulation, and age‐related disease

Aging Cell ◽  
2019 ◽  
Vol 18 (6) ◽  
Author(s):  
Adiv A. Johnson ◽  
Alexandra Stolzing
2013 ◽  
pp. 1-9
Author(s):  
C. TOMAS-ZAPICO ◽  
E. IGLESIAS-GUTIERREZ ◽  
B. FERNANDEZ-GARCIA ◽  
D. DE GONZALO-CALVO

Severe oxidative stress is a relevant risk factor for major deleterious health-related events in olderpeople and is thought to be an important contributor to age-related disease. Literature has suggested oxidativestress as a therapeutic target for mitigating the biological decline and attenuating the occurrence of adverseclinical events in aged individuals. However, definitive treatments are not known. Regular and moderate physicalactivity has been proposed as possible intervention for slowing age-related decline. This healthy strategy presentsa wide range of beneficial aspects for elderly, from the reduction of morbidity, disability, frailty and mortalityrates to treatment of many age-related disorders. Importantly, the global benefits on health are not shared by anyother strategies. Nevertheless, the physiological basis by which exercise produces its benefits to the organism isnot fully understood. This review summarizes the evidence for the role of physical activity as potential healthyintervention for mitigating the negative aspects of aging through the modulation of the oxidative mechanisms.


2014 ◽  
Vol 69 (Suppl 1) ◽  
pp. S28-S32 ◽  
Author(s):  
A. G. Richardson ◽  
E. E. Schadt

Author(s):  
Christopher Fortenbach ◽  
Elissa Goldman ◽  
Amar U. Kishan ◽  
Shilpa Mathew ◽  
Bobeck S. Modjtahedi ◽  
...  

2013 ◽  
Vol 48 (7) ◽  
pp. 612-613 ◽  
Author(s):  
Cheryl A. Conover
Keyword(s):  

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Michael Landowski ◽  
Vijesh J. Bhute ◽  
Tetsuya Takimoto ◽  
Samuel Grindel ◽  
Pawan K. Shahi ◽  
...  

AbstractAging is a significant factor in the development of age-related diseases but how aging disrupts cellular homeostasis to cause age-related retinal disease is unknown. Here, we further our studies on transmembrane protein 135 (Tmem135), a gene involved in retinal aging, by examining the transcriptomic profiles of wild-type, heterozygous and homozygous Tmem135 mutant posterior eyecup samples through RNA sequencing (RNA-Seq). We found significant gene expression changes in both heterozygous and homozygous Tmem135 mutant mouse eyecups that correlate with visual function deficits. Further analysis revealed that expression of many genes involved in lipid metabolism are changed due to the Tmem135 mutation. Consistent with these changes, we found increased lipid accumulation in mutant Tmem135 eyecup samples. Since mutant Tmem135 mice have similar ocular pathologies as human age-related macular degeneration (AMD) eyes, we compared our homozygous Tmem135 mutant eyecup RNA-Seq dataset with transcriptomic datasets of human AMD donor eyes. We found similar changes in genes involved in lipid metabolism between the homozygous Tmem135 mutant eyecups and AMD donor eyes. Our study suggests that the Tmem135 mutation affects lipid metabolism as similarly observed in human AMD eyes, thus Tmem135 mutant mice can serve as a good model for the role of dysregulated lipid metabolism in AMD.


2021 ◽  
Vol 8 (2) ◽  
pp. 42-45
Author(s):  
Zehra Zaidi ◽  
Shehla Nazir ◽  
Abdul Nasir ◽  
Minhaj Ahmad

The average human life expectancy has increased in recent times, so there is more focus on aging, age-related disease, and geriatric care in society. Older malnourished adults are more likely to have poorer health outcomes, longer hospital stays, and increased mortality, so there is a need to provide a nutritious and healthy diet to the old age population.Recent studies have shown that some medicinal herbs are effective in the intervention or prevention of aging-associated neurological disorders. Unani System of Medicine is one of the old traditional medicines in the world providing health care to humanity for centuries successively through natural safe, effective, and economic herbal medicine.Diets recommended for the old age population have been highlighted in this article with special emphasis on the traditional diets mentioned in the USM for geriatric care. There is a need to explore USM for better care of old age population and to find out an effective, safe, and economic treatment for old age diseases like Parkinson's disease and Alzheimer's disease, etc.


Sign in / Sign up

Export Citation Format

Share Document