scholarly journals Role of PAPP-A in aging and age-related disease

2013 ◽  
Vol 48 (7) ◽  
pp. 612-613 ◽  
Author(s):  
Cheryl A. Conover
Keyword(s):  
Related Disease ◽  
Age Related

PHYSICAL ACTIVITY AS HEALTHY INTERVENTION AGAINST SEVERE OXIDATIVE STRESS IN ELDERLY POPULATION

2013 ◽  
pp. 1-9
Author(s):  
C. TOMAS-ZAPICO ◽  
E. IGLESIAS-GUTIERREZ ◽  
B. FERNANDEZ-GARCIA ◽  
D. DE GONZALO-CALVO
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Elderly Population ◽  
Physiological Basis ◽  
Related Disease ◽  
Age Related ◽  
Wide Range ◽  
Health Related ◽  
Relevant Risk Factor

Severe oxidative stress is a relevant risk factor for major deleterious health-related events in olderpeople and is thought to be an important contributor to age-related disease. Literature has suggested oxidativestress as a therapeutic target for mitigating the biological decline and attenuating the occurrence of adverseclinical events in aged individuals. However, definitive treatments are not known. Regular and moderate physicalactivity has been proposed as possible intervention for slowing age-related decline. This healthy strategy presentsa wide range of beneficial aspects for elderly, from the reduction of morbidity, disability, frailty and mortalityrates to treatment of many age-related disorders. Importantly, the global benefits on health are not shared by anyother strategies. Nevertheless, the physiological basis by which exercise produces its benefits to the organism isnot fully understood. This review summarizes the evidence for the role of physical activity as potential healthyintervention for mitigating the negative aspects of aging through the modulation of the oxidative mechanisms.

scholarly journals The Role of Macromolecular Damage in Aging and Age-related Disease

2014 ◽  
Vol 69 (Suppl 1) ◽  
pp. S28-S32 ◽  
Author(s):  
A. G. Richardson ◽  
E. E. Schadt
Keyword(s):  
Related Disease ◽  
Age Related ◽  
Macromolecular Damage

scholarly journals Role of diet in old age

2021 ◽  
Vol 8 (2) ◽  
pp. 42-45
Author(s):  
Zehra Zaidi ◽  
Shehla Nazir ◽  
Abdul Nasir ◽  
Minhaj Ahmad
Keyword(s):  
Old Age ◽  
Neurological Disorders ◽  
Human Life ◽  
Geriatric Care ◽  
Traditional Medicines ◽  
Related Disease ◽  
Age Related ◽  
The World ◽  
Hospital Stays

The average human life expectancy has increased in recent times, so there is more focus on aging, age-related disease, and geriatric care in society. Older malnourished adults are more likely to have poorer health outcomes, longer hospital stays, and increased mortality, so there is a need to provide a nutritious and healthy diet to the old age population.Recent studies have shown that some medicinal herbs are effective in the intervention or prevention of aging-associated neurological disorders. Unani System of Medicine is one of the old traditional medicines in the world providing health care to humanity for centuries successively through natural safe, effective, and economic herbal medicine.Diets recommended for the old age population have been highlighted in this article with special emphasis on the traditional diets mentioned in the USM for geriatric care. There is a need to explore USM for better care of old age population and to find out an effective, safe, and economic treatment for old age diseases like Parkinson's disease and Alzheimer's disease, etc.

scholarly journals Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study

2016 ◽  
Vol 17 (5-6) ◽  
pp. 893-905 ◽  
Author(s):  
Alexander M. Kulminski ◽  
Nalini Raghavachari ◽  
Konstantin G. Arbeev ◽  
Irina Culminskaya ◽  
Liubov Arbeeva ◽  
...  
Keyword(s):  
Family Study ◽  
Protective Role ◽  
Related Disease ◽  
Age Related ◽  
Long Life

scholarly journals The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease

2012 ◽  
Vol 15 (5) ◽  
pp. 483-494 ◽  
Author(s):  
Adiv A. Johnson ◽  
Kemal Akman ◽  
Stuart R.G. Calimport ◽  
Daniel Wuttke ◽  
Alexandra Stolzing ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Related Disease ◽  
Age Related

scholarly journals Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity

2013 ◽  
Vol 93 (2) ◽  
pp. 571-598 ◽  
Author(s):  
Andrzej Bartke ◽  
Liou Y. Sun ◽  
Valter Longo
Keyword(s):  
Insulin Signaling ◽  
Single Gene ◽  
Postnatal Growth ◽  
Related Disease ◽  
Experimental Systems ◽  
Trade Offs ◽  
Age Related ◽  
Evolutionarily Conserved ◽  
Extended Longevity

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling delays aging and remarkably extends longevity in laboratory mice. In GH-deficient and GH-resistant animals, the “healthspan” is also extended with delays in cognitive decline and in the onset of age-related disease. The role of hormones homologous to insulin-like growth factor (IGF, an important mediator of GH actions) in the control of aging and lifespan is evolutionarily conserved from worms to mammals with some homologies extending to unicellular yeast. The combination of reduced GH, IGF-I, and insulin signaling likely contributes to extended longevity in GH or GH receptor-deficient organisms. Diminutive body size and reduced fecundity of GH-deficient and GH-resistant mice can be viewed as trade-offs for extended longevity. Mechanisms responsible for delayed aging of GH-related mutants include enhanced stress resistance and xenobiotic metabolism, reduced inflammation, improved insulin signaling, and various metabolic adjustments. Pathological excess of GH reduces life expectancy in men as well as in mice, and GH resistance or deficiency provides protection from major age-related diseases, including diabetes and cancer, in both species. However, there is yet no evidence of increased longevity in GH-resistant or GH-deficient humans, possibly due to non-age-related deaths. Results obtained in GH-related mutant mice provide striking examples of mutations of a single gene delaying aging, reducing age-related disease, and extending lifespan in a mammal and providing novel experimental systems for the study of mechanisms of aging.

scholarly journals X-linked dystonia-parkinsonism: over and above a repeat disorder

2021 ◽  
Vol 33 (4) ◽  
pp. 319-324
Author(s):  
Jelena Pozojevic ◽  
Joseph Neos Cruz ◽  
Ana Westenberger
Keyword(s):  
Disease Onset ◽  
Repeat Expansion ◽  
Clinical Parameters ◽  
Adult Onset ◽  
Related Disease ◽  
Hexanucleotide Repeat ◽  
Age Related ◽  
Disease Penetrance ◽  
Molecular Aspects

Abstract X-linked dystonia-parkinsonism (XDP) is an adult-onset neurodegenerative movement disorder, caused by a founder retrotransposon insertion in an intron of the TAF1 gene. This insertion contains a polymorphic hexanucleotide repeat (CCCTCT)n, the length of which inversely correlates with the age at disease onset (AAO) and other clinical parameters, aligning XDP with repeat expansion disorders. Nevertheless, many other pathogenic mechanisms are conceivably at play in XDP, indicating that in contrast to other repeat disorders, the (CCCTCT)n repeat may not be the actual (or only) disease cause. Here, we summarize and discuss genetic and molecular aspects of XDP, highlighting the role of the hexanucleotide repeat in age-related disease penetrance and expressivity.

The role of apoptosis in aging and age-related disease: update

2001 ◽  
Vol 34 (6) ◽  
pp. 441-446 ◽  
Author(s):  
K. Muradian ◽  
D. O. Schachtschabel
Keyword(s):  
Related Disease ◽  
Age Related
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