scholarly journals Allergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome

2018 ◽  
Vol 31 (3) ◽  
pp. 158-165 ◽  
Author(s):  
Jaime S. Rosa ◽  
Joseph D. Hernandez ◽  
Janell A. Sherr ◽  
Bridget M. Smith ◽  
Kayla D. Brown ◽  
...  
Keyword(s):  
Allergic Diseases ◽  
Acute Onset ◽  
Immune Mediated

scholarly journals Presumed immune-mediated haemolytic anaemia associated with pregnancy in a cat

2019 ◽  
Vol 5 (1) ◽  
pp. 205511691984168
Author(s):  
Matthew A Kopke ◽  
Sarah Pemberton ◽  
Craig G Ruaux
Keyword(s):  
Haemolytic Anaemia ◽  
Cardiac Activity ◽  
Abdominal Ultrasound ◽  
Serum Biochemistry ◽  
Acute Onset ◽  
Gram Staining ◽  
Case Summary ◽  
Immune Mediated ◽  
Large Uterus ◽  
Saline Test

Case summary A 7-year-old female entire Birman presented with acute-onset haemorrhagic vulvar discharge. Moderate, normocytic, normochromic, non-/pre-regenerative anaemia, along with a moderate mature neutrophilia, were seen on haematology. Saline test for agglutination was positive. No haemotropic mycoplasmas were identified. Serum biochemistry revealed severe hyperbilirubinaemia. Retroviral testing was negative. Serology for toxoplasmosis revealed a titre of 1:512. Abdominal ultrasound identified a large uterus, containing at least three advanced-stage fetuses, two of which failed to exhibit independent motion or cardiac activity. Ovariohysterectomy was performed. Histology demonstrated mild, multifocal suppurative placentitis, with Gram staining revealing no evidence of bacteria. Complete resolution of the anaemia was seen within 1.5 months of ovariohysterectomy. Relevance and novel information Immune-mediated haemolytic anaemia (IMHA) in association with pregnancy has not been previously reported in cats. This case represents a potential novel cause for IMHA in cats, which resolved following ovariohysterectomy.

scholarly journals ncRNAs in Type-2 Immunity

2020 ◽  
Vol 6 (1) ◽  
pp. 10 ◽  
Author(s):  
Riccardo Guidi ◽  
Christopher J. Wedeles ◽  
Mark S. Wilson
Keyword(s):  
Immune Responses ◽  
Immune Cell ◽  
Allergic Diseases ◽  
Parasitic Helminths ◽  
Medical Needs ◽  
Type 2 Immunity ◽  
Non Coding Rna ◽  
Immune Mediated ◽  
Immunological Diseases

Immunological diseases, including asthma, autoimmunity and immunodeficiencies, affect a growing percentage of the population with significant unmet medical needs. As we slowly untangle and better appreciate these complex genetic and environment-influenced diseases, new therapeutically targetable pathways are emerging. Non-coding RNA species, which regulate epigenetic, transcriptional and translational responses are critical regulators of immune cell development, differentiation and effector function, and may represent one such new class of therapeutic targets. In this review we focus on type-2 immune responses, orchestrated by TH2 cell-derived cytokines, IL-4, IL-5 and IL-13, which stimulate a variety of immune and tissue responses- commonly referred to as type-2 immunity. Evolved to protect us from parasitic helminths, type-2 immune responses are observed in individuals with allergic diseases, including Asthma, atopic dermatitis and food allergy. A growing number of studies have identified the involvement of various RNA species, including microRNAs (miRNA) and long non-coding (lncRNA), in type-2 immune responses and in both clinical and pre-clinical disease settings. We highlight these recent findings, identify gaps in our understanding and provide a perspective on how our current understanding can be harnessed for novel treat opportunities to treat type-2 immune-mediated diseases.

scholarly journals “Acute onset tetraplegia associated with immune‐mediated thrombocytopenia and suspected secondary intraspinal hemorrhage in a dog”

2019 ◽  
Vol 7 (9) ◽  
pp. 1673-1679
Author(s):  
Jasmine S. Lee ◽  
Tara Jane Bellis ◽  
Adam S. Yoskowitz ◽  
Boaz Levitin
Keyword(s):  
Acute Onset ◽  
Immune Mediated ◽  
Intraspinal Hemorrhage

The Application of Clinical, Electrophysiological and Nerve Ultrasound Parameters in Distinguishing Acute-onset Chronic from Acute Inflammatory Demyelinating Polyneuropathy

2015 ◽  
Vol 10 (01) ◽  
pp. 85 ◽  
Author(s):  
Antonios Kerasnoudis ◽  
Kallia Pitarokoili ◽  
Ralf Gold ◽  
Min-Suk Yoon ◽  
◽  
...  
Keyword(s):  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Acute Onset ◽  
Demyelinating Polyneuropathy ◽  
Nerve Ultrasound ◽  
Diagnostic Challenge ◽  
Early Application ◽  
Immune Mediated ◽  
Inflammatory Demyelinating Polyneuropathy ◽  
Ultrasound Parameters

History-taking and nerve conduction studies are fundamental for the diagnosis and assessment of the severity of acute (AIDP) or chronic inflammatory demyelinating polyneuropathy (CIDP). The diagnostic challenge of distinguishing these two immune-mediated subacute polyradiculoneuropathies remains high, as intravenous immunoglobulin and steroids exert short-term clinical improvement in the majority of the CIDP cases, whereas steroids have no effect on AIDP patients. Accordingly, the precise classification of subacute polyradiculoneuropathies significantly affects the early application of steroids in CIDP. This review aims to give a timely update on the application of clinical, electrophysiological and nerve ultrasound parameters in distinguishing subacute CIDP from AIDP.

scholarly journals Mesenchymal stem/stromal cell therapy in atopic dermatitis and chronic urticaria: immunological and clinical viewpoints

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Eun-Young Kim ◽  
Hyuk Soon Kim ◽  
Ki-Sung Hong ◽  
Hyung-Min Chung ◽  
Se-Pill Park ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Cell Therapy ◽  
Chronic Urticaria ◽  
Stromal Cells ◽  
Stromal Cell ◽  
Allergic Diseases ◽  
Therapeutic Modality ◽  
Specific Disease ◽  
Immune Mediated

AbstractAllergic diseases are immune-mediated diseases. Allergies share a common immunopathogenesis, with specific differences according to the specific disease. Mesenchymal stem/stromal cells (MSCs) have been applied to people suffering from allergic and many other diseases. In this review, the immunologic roles of MSCs are systemically reviewed according to disease immunopathogenesis from a clinical viewpoint. MSCs seem to be a promising therapeutic modality not only as symptomatic treatments but also as causative and even preventive treatments for allergic diseases, including atopic dermatitis and chronic urticaria.

scholarly journals Biological treatment provides disease-modifying immunological effects

2021 ◽  
Author(s):  
Mohamed Shamji ◽  
Elizabeth Palmer ◽  
Janice Layhadi ◽  
Theo Moraes ◽  
Thomas Eiwegger
Keyword(s):  
Biological Treatment ◽  
Symptom Control ◽  
Allergic Diseases ◽  
Chronic Spontaneous Urticaria ◽  
Biological Therapies ◽  
Promising Alternative ◽  
Immune Mediated ◽  
Alternative Treatment Option ◽  
Immunological Effects

Advances in molecular biology alongside the accelerated development of gene and cell engineering have contributed to the development of several endotype-targeted biological therapies against chronic immune-mediated allergic diseases. Conventional therapies for asthma, chronic rhinosinusitis with polyposis (CRSwNP), chronic spontaneous urticaria and atopic dermatitis (AD) are not without limitations, and as such the advent of biological therapies have provided a promising alternative treatment option. Biologicals have proven efficacious in the treatment of refractory chronic spontaneous urticaria, asthma, AD, CRSwNP and there is increasing evidence for their utility in treating food allergy. Biologicals are applied and investigated for the most urgent need: acute treatment, symptom control and reduction of steroid usage. Currently there are five approved biologicals for allergic disease management, targeted against IgE (omalizumab), type 2 (T2) cytokines and cytokine receptors (IL-4Ra; dupilumab, IL-5; mepolizumab/reslizumab, IL-5Ra; benralizumab).

Autoimmune hemolytic anemia in a dachshund bitch – a case report

2017 ◽  
Vol XXII (128) ◽  
pp. 70-78
Author(s):  
João Otávio Sacchi ◽  
Marilene Machado Silva ◽  
Jessica Crespi Sabadin ◽  
Jessica Naiara Voitena ◽  
Lindomar Fernandes Pessoa ◽  
...  
Keyword(s):  
Hemolytic Anemia ◽  
Acute Onset ◽  
Cell Agglutination ◽  
Laboratory Findings ◽  
Immune Mediated ◽  
Positive Treatment ◽  
Primary Origin ◽  
Inflammatory Drugs ◽  
Premature Removal

Immune-mediated hemolytic anemia leads to the premature removal of erythrocytes. It is a type 2 hypersensitivity reaction in which erythrocytes are covered by antibodies or complement and are phagocytized in the spleen or lysed within the blood vessels. It is considered of primary origin when the causes of the onset of the disease are unknown, or regarded as secondary when resulting from external antigens. The diagnosis may be therapeutic or based on the direct positive Coombs test in conjunction with laboratory findings, such as moderate to severe variable regeneration anemia, polychromasia, spherocytosis, red blood cell agglutination, hyperbilirubinemia, and hemoglobinuria. Treatment is based on immunosuppressive doses of steroidal anti-inflammatory drugs such as prednisone. This paper reports the case of an acute onset in a dog diagnosed with primary immune-mediated hemolytic anemia, presenting apathy, dyspnea, pain upon abdominal palpation, splenomegaly and pale mucous membranes. Coombs direct test was positive. Treatment started with prednisone, but as the response was not favorable, other drugs were associated to it. Evolution was unfavorable and the owner opted for euthanasia due to poor prognosis.

scholarly journals Traumatic Blepharitis Including Cutanous Changes with a Clinical Appearance of Immune-Mediated Disease

2021 ◽  
Vol 71 (1) ◽  
pp. 120-130
Author(s):  
Kecova Helga ◽  
Milcic-Matic Natalija ◽  
Lazic Tatjana ◽  
Grozdanic Sinisa
Keyword(s):  
Skin Disease ◽  
Clinical Presentation ◽  
Acute Onset ◽  
Intact Male ◽  
Clinical Appearance ◽  
Immune Mediated ◽  
Traumatic Origin ◽  
Ulcerative Lesions ◽  
Systemic Examination ◽  
Systemic Antibiotic Treatment

Abstract A four-year-old intact male Labrador retriever was presented with acute onset of ulcerative lesions around both eyes, on the mucocutaneous junctions around the muzzle and nares, and on the lateral aspects of paw pads. All lesions were symmetrical and well demarcated. The rest of ocular and systemic examination was unremarkable. The onset of lesions was acute and coincided with an episode of intense hunting in switchgrass. Similar lesions were present in another dog used in the same hunting trip. The clinical presentation was suggestive of a possible immune-mediated skin disease. However, the patient responded to systemic antibiotic treatment with full recovery without recurrence upon cessation of therapy. Traumatic origin should be included into differential diagnosis of mucocutaneous ulcerative lesions presenting as a possible immune-mediated skin disease.

scholarly journals A juvenilis és felnőttkori dermatomyositises betegek klinikai jellemzői

2015 ◽  
Vol 156 (37) ◽  
pp. 1491-1496 ◽  
Author(s):  
Orsolya Szalmás ◽  
Melinda Nagy-Vince ◽  
Katalin Dankó ◽  
Flóra Farkas
Keyword(s):  
Juvenile Dermatomyositis ◽  
Acute Onset ◽  
Adult Patients ◽  
Published Data ◽  
Inflammatory Myopathies ◽  
Proximal Muscle ◽  
Immune Mediated ◽  
Skin Symptoms ◽  
Typical Skin

Introduction: Juvenile and adult dermatomysitis are chronic, immune-mediated inflammatory myopathies characterized by progressive proximal muscle weakness and typical skin symptoms. Aim: To compare the symptoms, laboratory and serological findings, treatment and disease course in children and adults suffering from dermatomyositis. Method: In this retrospective study, juvenile and adult dermatomyositis groups were formed. There were 27 patients with juvenile dermatomyositis (mean age, 8.7 years; mean follow-up time: 104.6 months) and 30 adult patients (mean age, 50.3; mean follow-up time: 58.1 months). Results: In patients with juvenile dermatomyositis, treatment with intravenous immunoglobulin and cyclosporine A were more frequent as compared to adult patients. Acute onset of the disease was more frequent in adult patients than in those with juvenile disease. In children symptoms of the disease developed gradually. Conclusions: The findings confirm previously published data showing that there are differences between juvenile and adult patients with dermatomyositis. The authors recommend to follow the patients regularly after reaching remission to avoid bad patient compliance and decrease the number and severity of relapses. Orv. Hetil., 2015, 156(37), 1491–1496.

Sign in / Sign up

Export Citation Format

Share Document