scholarly journals The role of the dermatologist in the immune‐mediated/allergic diseases – position statement of the EADV task force on contact dermatitis, EADV task force on occupational skin diseases, UEMS‐EBDV subcommission allergology and European Dermatology Forum

2019 ◽  
Vol 33 (8) ◽  
pp. 1459-1464
Author(s):  
A. Balato ◽  
A. Raimondo ◽  
P. Arenberger ◽  
M. Bruze ◽  
M. Czarnecka‐Operacz ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Skin Diseases ◽  
Task Force ◽  
Allergic Diseases ◽  
Position Statement ◽  
Occupational Skin Diseases ◽  
Immune Mediated

scholarly journals IL-17C and IL-17RE Promote Wound Closure in a Staphylococcus aureus-Based Murine Wound Infection Model

2021 ◽  
Vol 9 (9) ◽  
pp. 1821
Author(s):  
Linda Pätzold ◽  
Alexandra Stark ◽  
Felix Ritzmann ◽  
Carola Meier ◽  
Thomas Tschernig ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Infection ◽  
Wound Closure ◽  
Skin Diseases ◽  
Infection Model ◽  
Interleukin 17 ◽  
Immune Mediated ◽  
Significant Difference ◽  
Infected Skin

The epithelial cytokine interleukin-17C (IL-17C) mediates inflammation through the interleukin 17 receptor E (IL-17RE). Prior studies showed a detrimental role of IL-17C in the pathogenesis of immune-mediated skin diseases (e.g., psoriasis). Here, we examined the role of IL-17C/IL-17RE in wound closure in a Staphylococcus aureus wound infection model. We demonstrate that wound closure is significantly delayed in IL-17RE (Il-17re−/−)- and 17C (Il-17c−/−)-deficient mice. There was no significant difference between WT, Il-17re−/−, and Il-17c−/− mice in the absence of infection. Deficiency for IL-17RE and IL-17C did not significantly affect the elimination of bacteria. IL-17C expression was increased in the epidermis of human S. aureus-infected skin. Our results indicate that the IL-17C/IL-17RE axis contributes to the closure of infected wounds but does not contribute to the elimination of S. aureus.

scholarly journals The Utility of a Questionnaire Proposal as an Analytic Diagnostic Tool in Healthcare Providers Occupational Hand Eczema

2020 ◽  
Vol 5 (1) ◽  
pp. 16-18
Author(s):  
Anca E. Chiriac ◽  
Tatiana Taranu ◽  
Anca Chiriac ◽  
Simona Roxana Georgescu ◽  
Liliana Foia ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Healthcare Providers ◽  
Allergic Diseases ◽  
Hand Eczema ◽  
Trigger Factor ◽  
Occupational Skin Diseases ◽  
Work Related ◽  
Latex Gloves ◽  
Occupational Hand Eczema ◽  
Associated Risk Factors

AbstractThe aim of this study was to estimate the prevalence of self-reported work-related and occupational hand eczema, as well as associated risk factors in hospitals and out-patient clinics in Romania. A standardized questionnaire was addressed to health professionals from different medical fields. Out of 245 healthcare providers who completed the survey, 235 were women (95.9%), and 243 were working more than 8 hours/day in hospitals (99.18%). Hand eczema was self-reported and documented in almost one third of the nurses (33.49%), the most frequently involved trigger factor being powdered latex gloves. A total of 207 (84.48%) individuals denied any present or past allergic diseases. Only one nurse declared that severe hand eczema was the cause of losing her job at the hospital. Exposure assessment is essential for the diagnosis of work-related or occupational skin diseases.

The structure of occupational skin diseases among workers of diverse industrial sectors of the Republic of Bashkortostan

2017 ◽  
pp. 30-32
Author(s):  
A.B. Bakirov ◽  
E.T. Valeyeva ◽  
A.U. Shagalina ◽  
A.A. Faskhutdinova ◽  
E.R. Abdrakhmanova ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Skin Diseases ◽  
Average Length ◽  
Allergic Diseases ◽  
Occupational Skin Diseases ◽  
Industrial Sectors ◽  
Republic Of Bashkortostan ◽  
Allergic Skin ◽  
Medium Level ◽  
The Republic

We have analysed the structure of occupational skin diseases diagnosed in workers of diverse industrial sectors of the Republic of Bashkortostan. It has been shown that allergic skin diseases rank first among occupational dermatoses which currently amount to 52 %. Average length of work employment in hazardous working conditions is 13,7 ± 12,2 years. Occupational allergic diseases are more common among medium-level healthcare workers. Occupational hyperkeratoses and skin cancer are mainly detected in continuous fiberglass workers.

scholarly journals Microbiota and Immune-Mediated Skin Diseases—An Overview

2019 ◽  
Vol 7 (9) ◽  
pp. 279 ◽  
Author(s):  
Adrian Catinean ◽  
Maria Adriana Neag ◽  
Andrei Otto Mitre ◽  
Corina Ioana Bocsan ◽  
Anca Dana Buzoianu
Keyword(s):  
Autoimmune Diseases ◽  
Beneficial Effect ◽  
Skin Diseases ◽  
Experimental Studies ◽  
Immune Mediated ◽  
The Impact ◽  
The Relationship

In recent years, increased attention has been paid to the relationship between microbiota and various diseases, especially immune-mediated diseases. Because conventional therapy for many autoimmune diseases is limited both in efficacy and safety, there is an increased interest in identifying nutraceuticals, particularly probiotics, able to modulate the microbiota and ameliorate these diseases. In this review, we analyzed the research focused on the role of gut microbiota and skin in immunity, their role in immune-mediated skin diseases (IMSDs), and the beneficial effect of probiotics in patients with this pathology. We selected articles published between 2009 and 2019 in PubMed and ScienceDirect that provided information regarding microbiota, IMSDs and the role of probiotics in these diseases. We included results from different types of studies including observational and interventional clinical trials or in vivo and in vitro experimental studies. Our results showed that probiotics have a beneficial effect in changing the microbiota of patients with IMSDs; they also influence disease progression. Further studies are needed to better understand the impact of new therapies on intestinal microbiota. It is also important to determine whether the microbiota of patients with autoimmune diseases can be manipulated in order to restore homeostasis of the microbiota.

scholarly journals Saliva Proteomics as Fluid Signature of Inflammatory and Immune-Mediated Skin Diseases

2021 ◽  
Vol 22 (13) ◽  
pp. 7018
Author(s):  
Anna Campanati ◽  
Emanuela Martina ◽  
Federico Diotallevi ◽  
Giulia Radi ◽  
Andrea Marani ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Human Saliva ◽  
Inflammatory Skin Diseases ◽  
Non Invasive ◽  
Diagnosis And Prognosis ◽  
Genomic Technologies ◽  
Immune Mediated ◽  
Saliva Analysis ◽  
Whole Saliva

Saliva is easy to access, non-invasive and a useful source of information useful for the diagnosis of serval inflammatory and immune-mediated diseases. Following the advent of genomic technologies and -omic research, studies based on saliva testing have rapidly increased and human salivary proteome has been partially characterized. As a proteomic protocol to analyze the whole saliva proteome is not currently available, the most common aim of the proteomic analysis is to discriminate between physiological and pathological conditions. The salivary proteome has been initially investigated in several diseases: oral squamous cell carcinoma and oral leukoplakia, chronic graft-versus-host disease, and Sjögren’s syndrome. Otherwise, salivary proteomics studies in the dermatological field are still in the initial phase, thus the aim of this review is to collect the best research evidence on the role of saliva proteomics analysis in immune-mediated skin diseases to understand the direction of research in this field. The results of PRISMA analysis reported herein suggest that human saliva analysis could provide significant data for the diagnosis and prognosis of several immune-mediated and inflammatory skin diseases in the next future.

The role of NLRP3 inflammasome in infection-related, immune-mediated and autoimmune skin diseases

2020 ◽  
Vol 98 (3) ◽  
pp. 146-151 ◽  
Author(s):  
Dan Wang ◽  
Brittany Duncan ◽  
Xizhe Li ◽  
Jian Shi
Keyword(s):  
Nlrp3 Inflammasome ◽  
Skin Diseases ◽  
Immune Mediated

scholarly journals The Relationship of Working Period with the Incidence of Occupational Contact Dermatitis in Cleaning Service Workers at Haji Adam Malik General Hospital Medan

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Veronica ◽  
Nova Zairina Lubis
Keyword(s):  
Contact Dermatitis ◽  
General Hospital ◽  
Skin Diseases ◽  
Occupational Skin Diseases ◽  
Cross Sectional ◽  
Service Workers ◽  
Occupational Contact Dermatitis ◽  
Relationship Of ◽  
The Relationship ◽  
Occupational Contact

Occupational skin diseases are the third most common occupational diseases. The most common occupational skin diseases are contact dermatitis covering 90-95%. The majority of contact dermatitis occurs in the hands. This study aims to determine the relationship of working period with the incidence of occupational contact dermatitis in cleaning service workers at Haji Adam Malik General Hospital Medan. This study is analytic method study which uses cross sectional design and uses questionnaire. Respondent were drawn using consecutive sampling. The study showed that 33,2% of cleaning service workers had contact dermatitis. The prevalence of contact dermatitis in women 75,8% and men 24,2%. The contact time for workers who come into contact chemical >2 hours is 100%. The use of PPE on cleaning service workers is 89,3%. Most ethnic group suffering from contact dermatitis are the 77,4% Batak people. The highest level cleaning service education is high school 59,4%. The results of the analysis with the chi square test of working life with the incidence of occupational contact dermatitis were (p=0,383). There is no significant relationship of working period with the incidence of occupational contact dermatitis in cleaning service workers at Haji Adam Malik General Hospital Medan

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