The Effects of Brain Injury on Heart Rate Variability and the Innate Immune Response in Critically Ill Patients

2012 ◽  
Vol 29 (5) ◽  
pp. 747-755 ◽  
Author(s):  
Matthijs Kox ◽  
Maarten Q. Vrouwenvelder ◽  
Jan C. Pompe ◽  
Johannes G. van der Hoeven ◽  
Peter Pickkers ◽  
...  
Keyword(s):  
Heart Rate ◽  
Immune Response ◽  
Heart Rate Variability ◽  
Brain Injury ◽  
Critically Ill ◽  
Innate Immune Response ◽  
Critically Ill Patients ◽  
Innate Immune

scholarly journals Interplay between the innate immune response and heart rate variability in healthy human volunteers

Critical Care ◽  
2011 ◽  
Vol 15 (S1) ◽  
Author(s):  
M Kox ◽  
BP Ramakers ◽  
JC Pompe ◽  
JG Van der Hoeven ◽  
CW Hoedemaekers ◽  
...  
Keyword(s):  
Heart Rate ◽  
Immune Response ◽  
Heart Rate Variability ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Healthy Human ◽  
Human Volunteers

Influence of gender on endotoxin-induced parameters of heart rate variability and innate immune response

2008 ◽  
Vol 207 (3) ◽  
pp. S39-S40
Author(s):  
Steven B. Watson ◽  
Maria Karavidas ◽  
Ashwini Kumar ◽  
Susette Coyle ◽  
Marie Macor ◽  
...  
Keyword(s):  
Heart Rate ◽  
Immune Response ◽  
Heart Rate Variability ◽  
Innate Immune Response ◽  
Innate Immune

scholarly journals Acute Kidney Injury Induces Innate Immune Response and Neutrophil Activation in the Lung

2020 ◽  
Vol 7 ◽  
Author(s):  
Akinori Maeda ◽  
Naoki Hayase ◽  
Kent Doi
Keyword(s):  
Immune Response ◽  
Acute Kidney Injury ◽  
Critically Ill ◽  
Innate Immune Response ◽  
Critically Ill Patients ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Neutrophil Activation ◽  
Innate Immune ◽  
Organ Crosstalk

Complication in acute kidney injury (AKI) is significantly associated with developing acute respiratory failure (ARF), while ARF is one of the most important risks for AKI. These data suggest AKI and ARF may synergistically worsen the outcomes of critically ill patients and these organ injuries may not occur independently. Organ crosstalk between the kidney and the lung has been investigated by using animal models so far. This review will focus on innate immune response and neutrophil activation among the mechanisms that contribute to this organ crosstalk. AKI increased the blood level of an inflammatory mediator in high-mobility group box 1, which induces an innate immune reaction via toll-like receptor 4. The remarkable infiltration of neutrophils to the lung was observed in animal AKI models. IL-6 and IL-8 have been demonstrated to contribute to pulmonary neutrophil activation in AKI. In addition, the formation of a neutrophil extracellular trap was also observed in the lung after the exposure of renal ischemia reperfusion in the animal model. Further investigation is necessary to determine whether targeting innate immune response and neutrophil activation will be useful for developing new therapeutics that could improve multiple organ failure in critically ill patients.

25-hydroxyvitamin D3 treatment normalize the vitamin D status and the innate immune response mediated by cathelicidin in critically ill patients

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S146-S147 ◽  
Author(s):  
J. Vargas-Vasserot ◽  
J.M. Mata-Granados ◽  
M. Luque de Castro ◽  
R. Guerrero Pavón ◽  
J. Quesada Gomez
Keyword(s):  
Vitamin D ◽  
Immune Response ◽  
Critically Ill ◽  
Innate Immune Response ◽  
Critically Ill Patients ◽  
Innate Immune ◽  
Vitamin D Status

scholarly journals Evaluation of peripheral perfusion index and heart rate variability as early predictors for intradialytic hypotension in critically ill patients

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hanan Mostafa ◽  
Mohamed Shaban ◽  
Ahmed Hasanin ◽  
Hassan Mohamed ◽  
Shymaa Fathy ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Pulmonary Oedema ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Perfusion Index ◽  
Intradialytic Hypotension ◽  
Peripheral Perfusion ◽  
Hemodialysis Session ◽  
Prophylactic Measures

Abstract Background Intradialytic hypotension is a serious complication during renal replacement therapy in critically ill patients. Early prediction of intradialytic hypotension could allow adequate prophylactic measures. In this study we evaluated the ability of peripheral perfusion index (PPI) and heart rate variability (HRV) to predict intradialytic hypotension. Methods A prospective observational study included 36 critically ill patients with acute kidney injury during their first session of intermittent hemodialysis. In addition to basic vital signs, PPI was measured using Radical-7 (Masimo) device. Electrical cardiometry (ICON) device was used for measuring cardiac output, systemic vascular resistance, and HRV. All hemodynamic values were recorded at the following time points: 30 min before the hemodialysis session, 15 min before the start of hemodialysis session, every 5 min during the session, and 15 min after the conclusion of the session. The ability of all variables to predict intradialytic hypotension was assessed through area under receiver operating characteristic (AUROC) curve calculation. Results Twenty-three patients (64%) had intradialytic hypotension. Patients with pulmonary oedema showed higher risk for development of intradialytic hypotension {Odds ratio (95% CI): 13.75(1.4–136)}. Each of baseline HRV, and baseline PPI showed good predictive properties for intradialytic hypotension {AUROC (95% CI): 0.761(0.59–0.88)}, and 0.721(0.547–0.857)} respectively. Conclusions Each of low PPI, low HRV, and the presence of pulmonary oedema are good predictors of intradialytic hypotension.

scholarly journals Guilty Molecules, Guilty Minds? The Conflicting Roles of the Innate Immune Response to Traumatic Brain Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-18 ◽  
Author(s):  
Sarah Claire Hellewell ◽  
Maria Cristina Morganti-Kossmann
Keyword(s):  
Traumatic Brain Injury ◽  
Immune Response ◽  
Brain Injury ◽  
Innate Immune Response ◽  
Complex Disease ◽  
Clinical Care ◽  
The Body ◽  
Innate Immune ◽  
Neuroprotective Therapy ◽  
Attractive Therapeutic Target

Traumatic brain injury (TBI) is a complex disease in the most complex organ of the body, whose victims endure lifelong debilitating physical, emotional, and psychosocial consequences. Despite advances in clinical care, there is no effective neuroprotective therapy for TBI, with almost every compound showing promise experimentally having disappointing results in the clinic. The complex and highly interrelated innate immune responses govern both the beneficial and deleterious molecular consequences of TBI and are present as an attractive therapeutic target. This paper discusses the positive, negative, and often conflicting roles of the innate immune response to TBI in both an experimental and clinical settings and highlights recent advances in the search for therapeutic candidates for the treatment of TBI.

scholarly journals Heart Rate Variability: Utility in Critically Ill Patients?

2020 ◽  
Author(s):  
G.L. Jones ◽  
V. Patel ◽  
A. Achunair ◽  
D.J. Patel ◽  
J. Chiong ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Critically Ill ◽  
Critically Ill Patients

scholarly journals Correction: Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252259
Author(s):  
Cristian Aragón-Benedí ◽  
Pablo Oliver-Forniés ◽  
Felice Galluccio ◽  
Ece Yamak Altinpulluk ◽  
Tolga Ergonenc ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Pilot Study ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Illness Severity
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