scholarly journals Interplay between the innate immune response and heart rate variability in healthy human volunteers

Critical Care ◽  
2011 ◽  
Vol 15 (S1) ◽  
Author(s):  
M Kox ◽  
BP Ramakers ◽  
JC Pompe ◽  
JG Van der Hoeven ◽  
CW Hoedemaekers ◽  
...  
Keyword(s):  
Heart Rate ◽  
Immune Response ◽  
Heart Rate Variability ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Healthy Human ◽  
Human Volunteers

The Effects of Brain Injury on Heart Rate Variability and the Innate Immune Response in Critically Ill Patients

2012 ◽  
Vol 29 (5) ◽  
pp. 747-755 ◽  
Author(s):  
Matthijs Kox ◽  
Maarten Q. Vrouwenvelder ◽  
Jan C. Pompe ◽  
Johannes G. van der Hoeven ◽  
Peter Pickkers ◽  
...  
Keyword(s):  
Heart Rate ◽  
Immune Response ◽  
Heart Rate Variability ◽  
Brain Injury ◽  
Critically Ill ◽  
Innate Immune Response ◽  
Critically Ill Patients ◽  
Innate Immune

Influence of gender on endotoxin-induced parameters of heart rate variability and innate immune response

2008 ◽  
Vol 207 (3) ◽  
pp. S39-S40
Author(s):  
Steven B. Watson ◽  
Maria Karavidas ◽  
Ashwini Kumar ◽  
Susette Coyle ◽  
Marie Macor ◽  
...  
Keyword(s):  
Heart Rate ◽  
Immune Response ◽  
Heart Rate Variability ◽  
Innate Immune Response ◽  
Innate Immune

Interplay Between the Acute Inflammatory Response and Heart Rate Variability in Healthy Human Volunteers

Shock ◽  
2011 ◽  
Vol 36 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Matthijs Kox ◽  
Bart P. Ramakers ◽  
Jan C. Pompe ◽  
Johannes G. van der Hoeven ◽  
Cornelia W. Hoedemaekers ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Inflammatory Response ◽  
Acute Inflammatory Response ◽  
Healthy Human ◽  
Human Volunteers

Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers*

2007 ◽  
Vol 35 (6) ◽  
pp. 1464-1469 ◽  
Author(s):  
Lucas T. van Eijk ◽  
Mirrin J. Dorresteijn ◽  
Paul Smits ◽  
Johannes G. van der Hoeven ◽  
Mihai G. Netea ◽  
...  
Keyword(s):  
Gender Differences ◽  
Immune Response ◽  
Innate Immune Response ◽  
Vascular Reactivity ◽  
Innate Immune ◽  
Human Volunteers

scholarly journals Endotoxin Exposure Increases LL-37 - but Not Calprotectin - in Healthy Human Airways

2017 ◽  
Vol 9 (5) ◽  
pp. 475-482 ◽  
Author(s):  
Margaretha E. Smith ◽  
Marit Stockfelt ◽  
Sara Tengvall ◽  
Peter Bergman ◽  
Anders Lindén ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Bacterial Colonization ◽  
Active Form ◽  
Innate Immune ◽  
Healthy Human ◽  
Peripheral Airways ◽  
Healthy Humans ◽  
Endotoxin Exposure ◽  
Human Airways

Rationale: The antimicrobial peptides (AMPs) LL-37 and calprotectin are important players in the innate immunity of human airways. In patients with diseases characterized by bacterial colonization, the airway concentrations of these AMPs are increased. Less is known about their presence and release patterns in healthy humans. Our aim was to determine whether LL-37 and calprotectin are released after the activation of the innate immune response in the peripheral airways. Methods: Healthy volunteers underwent exposure to endotoxin and vehicle in contralateral segment bronchi. After 12 or 24 h, samples of bronchoalveolar lavage fluid (BALf) were collected bilaterally from exposed segments. Cell and AMP concentrations were assessed, as were the pro-form and active form of LL-37. Results: Both LL-37 and calprotectin were detected in cell-free BALf from both endotoxin- and vehicle-exposed segments. The concentrations of precursor and active LL-37 and neutrophils were significantly higher in endotoxin-exposed segments after 12 and 24 h, and the concentrations of LL-37 and neutrophils correlated positively. The concentrations of calprotectin were not markedly affected by exposure to endotoxin. Conclusions: Local endotoxin exposure elicits the release and activation of LL-37 but not calprotectin in healthy human peripheral airways, suggesting an inducible involvement of LL-37 in the local innate immune response.

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

IL-17C is a mediator of respiratory epithelial innate immune response

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
P Pfeifer ◽  
M Voss ◽  
B Wonnenberg ◽  
M Bischoff ◽  
F Langer ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Respiratory Epithelial
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