Estimation of the Lymph Flow Through Thoracic Duct in Human Subjects Using the Urine Osmolarity: Applicable for Evaluating the Effectiveness of Manual Lymph Drainage

2021 ◽  
Author(s):  
Toshio Ohhashi ◽  
Yoshiko Kawai ◽  
Moyuru Hayashi ◽  
Tomomi Watanabe-Asaka
Keyword(s):  
Thoracic Duct ◽  
Human Subjects ◽  
Lymph Flow ◽  
Urine Osmolarity ◽  
Lymph Drainage ◽  
Manual Lymph Drainage ◽  
Flow Through

Evaluating Lymph Flow Through the Thoracic Duct Using Urine Osmolarity in Human Participants

2020 ◽  
Vol 18 (4) ◽  
pp. 351-356 ◽  
Author(s):  
Moyuru Hayashi ◽  
Tomomi Watanabe-Asaka ◽  
Daisuke Maejima ◽  
Sachiho Nagashio ◽  
Ryo Kajihara ◽  
...  
Keyword(s):  
Thoracic Duct ◽  
Lymph Flow ◽  
Urine Osmolarity ◽  
Flow Through ◽  
Human Participants

Effects of sustained lymph drainage on cardiovascular function and thoracic duct lymph in sheep

1989 ◽  
Vol 256 (4) ◽  
pp. R867-R874
Author(s):  
G. J. Valenzuela ◽  
C. W. Hewitt ◽  
G. C. Kramer ◽  
Y. Do ◽  
W. A. Hseuh
Keyword(s):  
Arterial Pressure ◽  
Plasma Protein ◽  
Thoracic Duct ◽  
Protein Concentration ◽  
Lymph Flow ◽  
Escape Rate ◽  
Thoracic Duct Lymph ◽  
Lymph Drainage ◽  
Plasma Protein Concentration ◽  
Duct Lymph

We studied the effect of lowering the plasma protein concentration on the cardiovascular function and thoracic duct lymph in awake adult sheep. Hypoproteinemia was induced in seven nonpregnant, splenectomized sheep by drainage of the thoracic duct lymph over a 5-day period. The plasma protein went from a mean of 6.4 +/- 0.2 (SE) to 4.9 +/- 0.2 g/dl on day 5, and the lymph-to-plasma protein concentration ratio decreased from 0.74 +/- 0.01 on day 1 to 0.48 +/- 0.04 on day 5. The percentage composition of the protein fractions in plasma and lymph remained unchanged. Lymph flow was 1.79 +/- 0.37 and 1.28 +/- 0.10 ml/min for days 1 and 5, respectively. Renin concentration in plasma increased 50-fold by day 5. Arterial pressure fell from 102.9 +/- 5.4 to 72.7 +/- 4.4 mmHg by day 5. Mean hematocrit was 28.9 +/- 1.7 at day 1, which was not significantly different than 24.6 +/- 2.9 at day 5 and indicated that the plasma volume did not decrease. Body weight also did not change significantly. There was a decrease in the transcapillary protein escape rate, determined as the thoracic lymph flow rate multiplied the lymph protein concentration, that suggests adaptations in the microcirculation to decrease vascular-to-interstitial protein transfer during hypoproteinemia. Hypoproteinemic animals also demonstrated greater vascular retention of a fluid volume challenge. In conclusion, the sheep adaptations to sustained hypoproteinemia produced by lymph drainage were a significant decrease in arterial pressure, large increases in vascular compliance and renin concentration, and reduced transcapillary escape rate of protein.(ABSTRACT TRUNCATED AT 250 WORDS)

Reduced Lymphatic Drainage of Dialysate from the Peritoneal Cavity during Acute Peritonitis in Sheep

1996 ◽  
Vol 16 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Helen Rodela ◽  
Zheng-Yi Yuan ◽  
John B. Hay ◽  
Dimitrios G. Oreopoulos ◽  
Miles G. Johnston
Keyword(s):  
Peritoneal Cavity ◽  
Thoracic Duct ◽  
Mediastinal Lymph Node ◽  
Lymphatic Drainage ◽  
Lymph Flow ◽  
Lymph Drainage ◽  
Total Recovery ◽  
Acute Peritonitis ◽  
Conscious Sheep ◽  
The Right

Objectives The purpose of this study was to investigate the effects of acute peritonitis on lymphatic drainage of the peritoneal cavity in conscious sheep Design Peritonitis was induced with the addition of 1% casein or 1% albumin to the dialysis solution. Thirty sheep (5 groups of 6) were used in this study. One group received 50 mL/kg intraperitoneal infusions of Dianeal 4.25% (486 mOsm/L); a second group received 1% casein-DianeaI4.25% (493 mOsm/L); a third group received 1% albumin-Dianeal 4.25% (487 mOsm/L). In the fourth and fifth groups (controls and casein-injected) lymph was collected from the caudal mediastinal lymph node and the thoracic duct, both of which are involved in the lymphatic drainage of the peritoneal cavity (peritonitis induced with casein). 1251-human serum albumin (25 μCi) was added to the dialysate as the lymph flow marker. Lymph drainage was estimated from (1) the appearance of the intraperitoneally administered tracer in the blood; (2) the disappearance of the tracer from the peritoneal cavity; and (3) the recovery of tracer in lymph. Results In noncannulated animals the cumulative volume removed by lymphatics over 6 hours (based on tracer recovery in blood) was 10.5 ±1.0 mL/kg in control animals versus 5.0 ± 0.6 mL/kg and 8.6 ± 1.2 mL/kg in casein and albumin-infused sheep, respectively. The suggestion of decreased lymph drainage in peritonitis was supported by the cannulation experiments. While the cumulative fluid removed from the peritoneal cavity over 6 hours in caudal lymph was unaffected by peritonitis (3.8 ± 0.4 mL/kg in controls vs 3.6 ± 0.5 mL/kg in casein injected animals), peritonitis reduced flow into the thoracic duct from 3.0 ± 0.3 to 1.1 ± 0.3 mL/kg. The sum of the volume removed in lymph in the cannulated preparations was 6.8 ± 0.4 mL/kg in controls versus 4.7 ± 0.5 mL/kg in the peritonitis group. The total volume removed from the cavity (including an estimate of flow based on the residual recovery of tracer in blood) was reduced from 12.6 ±1.4 in controls to 7.8 ± 0.6 mL/kg in the peritonitis sheep. In contrast, estimates of lymph drainage based on the disappearance of tracer from the peritoneal cavity suggested that lymph drainage increased (from 16.6 ±1.6 mL/kg in controls to 17.8 ±1.5 mL/kg and 25.5 ±1.7 mL/kg in the casein and albumin groups, respectively, in noncannulated animals and from 15.3 ± 1.4 mL/kg in controls to 25.0 ± 1.7 mL/kg in the cannulated group). In both noncannulated and cannulated sheep the total recovery of tracer was less in the peritonitis groups. Conclusions These studies demonstrated that lymph drainage of the peritoneal space was decreased in a casein peritonitis model. The decrease in lymph drainage is most obvious in the visceral pathway leading to the thoracic duct; however, diaphragmatic drainage into the right lymph duct may also be inhibited. The disappearance of tracer from the peritoneal cavity was elevated during peritonitis. Tracer disappearance has been used to estimate lymph drainage, but this approach suggested, incorrectly, that lymph flow had increased.

scholarly journals Effect of Skim-Milk Feeding on the Flow and Composition of Thoracic Duct and Intestinal Lymph in Young Calves

1969 ◽  
Vol 22 (1) ◽  
pp. 197 ◽  
Author(s):  
AD Shannon ◽  
AK Lasoelles
Keyword(s):  
Thoracic Duct ◽  
Total Protein ◽  
Protein Concentration ◽  
Skim Milk ◽  
Lymph Flow ◽  
Total Protein Concentration ◽  
Intestinal Lymph ◽  
Flow Through ◽  
Effect Of Feeding ◽  
Milk Feeding

The effect of feeding skim milk on the flow and composition of lymph from thoracic and intestinal ducts was studied in young calves by means of lymphatico-venous shunts. The changes observed were similar for both thoracic duct and intestinal lymph. Skim-milk feeding significantly reduced lymph flow but had no effect on total protein concentration in lymph and no effect on lymph: plasma ratios for total protein concentration. It is suggested that the reduction in lymph flow observed when calves are fed skim milk is due to a decreased blood flow through the intestinal capillaries.

Lymphedema and lipedema - an overview of conservative treatment

VASA ◽  
2011 ◽  
Vol 40 (4) ◽  
pp. 271-279 ◽  
Author(s):  
Wagner
Keyword(s):  
Conservative Treatment ◽  
General Practitioners ◽  
Subcutaneous Tissue ◽  
Compression Therapy ◽  
Compression Stocking ◽  
Lymph Drainage ◽  
Intensive Phase ◽  
Manual Lymph Drainage ◽  
Causal Therapy

Lymphedema and lipedema are chronic progressive disorders for which no causal therapy exists so far. Many general practitioners will rarely see these disorders with the consequence that diagnosis is often delayed. The pathophysiological basis is edematization of the tissues. Lymphedema involves an impairment of lymph drainage with resultant fluid build-up. Lipedema arises from an orthostatic predisposition to edema in pathologically increased subcutaneous tissue. Treatment includes complex physical decongestion by manual lymph drainage and absolutely uncompromising compression therapy whether it is by bandage in the intensive phase to reduce edema or with a flat knit compression stocking to maintain volume.

Dr. Vodder's Manual Lymph Drainage

2010 ◽  
Author(s):  
Hildegard Wittlinger ◽  
Dieter Wittlinger ◽  
Wittlinger ,
Keyword(s):  
Lymph Drainage ◽  
Manual Lymph Drainage

Krypton 85 myocardial blood flow: precordial scintillation versus coronary sinus sampling

1965 ◽  
Vol 209 (4) ◽  
pp. 705-710 ◽  
Author(s):  
Michael D. Klein ◽  
Lawrence S. Cohen ◽  
Richard Gorlin
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Coronary Sinus ◽  
Human Subjects ◽  
Radioactive Decay ◽  
Empirical Correction ◽  
Wide Range ◽  
Actual Flow ◽  
Flow Through ◽  
High Degree

Myocardial blood flow in human subjects was assessed by comparative simultaneous measurement of krypton 85 radioactive decay from coronary sinus and precordial scintillation. Empirical correction of postclearance background from precordial curves yielded a high degree of correlation between flows derived from the two sampling sites (r = .889, P < .001). Comparison of left and right coronary flows in nine subjects revealed similarity in flow through the two vessels over a wide range of actual flow values (r = .945, P < .001).

scholarly journals The velocity of lymph flow in the canine thoracic duct

1974 ◽  
Vol 237 (2) ◽  
pp. 401-413 ◽  
Author(s):  
N. L. Browse ◽  
D. R. Rutt ◽  
D. Sizeland ◽  
Alexis Taylor
Keyword(s):  
Thoracic Duct ◽  
Lymph Flow
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