Interleukin-10 and Th2 Cytokines Differentially Regulate Osteopontin Expression in Human Monocytes and Dendritic Cells

2006 ◽  
Vol 26 (8) ◽  
pp. 562-567 ◽  
Author(s):  
Satoshi Konno ◽  
John A. Eckman ◽  
Beverly Plunkett ◽  
Xinfang Li ◽  
Jeffery S. Berman ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Interleukin 10 ◽  
Th2 Cytokines ◽  
Human Monocytes ◽  
Osteopontin Expression

Induction of interleukin‐10 expression through Fcα receptor in human monocytes and monocyte‐derived dendritic cells: role of p38 MAPKinase

2010 ◽  
Vol 88 (4) ◽  
pp. 486-493 ◽  
Author(s):  
Charles Pilette ◽  
Bruno Detry ◽  
Amélie Guisset ◽  
Julie Gabriels ◽  
Yves Sibille
Keyword(s):  
Dendritic Cells ◽  
Interleukin 10 ◽  
Human Monocytes

Regulation of osteopontin by IL-10 and Th2 cytokines in human monocytes and monocyte-derived dendritic cells

2006 ◽  
Vol 117 (2) ◽  
pp. S256
Author(s):  
S. Konno ◽  
N. Hizawa ◽  
J.A. Eckman ◽  
B. Plunkett ◽  
D.B.K. Golden ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Th2 Cytokines ◽  
Human Monocytes

scholarly journals Effect of serotonin on the differentiation of human monocytes into dendritic cells

2006 ◽  
Vol 146 (2) ◽  
pp. 354-361 ◽  
Author(s):  
N. Katoh ◽  
F. Soga ◽  
T. Nara ◽  
R. Tamagawa-Mineoka ◽  
M. Nin ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Human Monocytes

scholarly journals CD4+ CD25+ Foxp3+ Regulatory T Cells, Dendritic Cells, and Circulating Cytokines in Uncomplicated Malaria: Do Different Parasite Species Elicit Similar Host Responses?

2010 ◽  
Vol 78 (11) ◽  
pp. 4763-4772 ◽  
Author(s):  
Raquel M. Gonçalves ◽  
Karina C. Salmazi ◽  
Bianca A. N. Santos ◽  
Melissa S. Bastos ◽  
Sandra C. Rocha ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Parasite Species ◽  
Inflammatory Responses ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Surface Expression ◽  
Interleukin 10 ◽  
Treg Cells ◽  
Experimental Models ◽  
Necrosis Factor Alpha

ABSTRACT Clearing blood-stage malaria parasites without inducing major host pathology requires a finely tuned balance between pro- and anti-inflammatory responses. The interplay between regulatory T (Treg) cells and dendritic cells (DCs) is one of the key determinants of this balance. Although experimental models have revealed various patterns of Treg cell expansion, DC maturation, and cytokine production according to the infecting malaria parasite species, no studies have compared all of these parameters in human infections with Plasmodium falciparum and P. vivax in the same setting of endemicity. Here we show that during uncomplicated acute malaria, both species induced a significant expansion of CD4+ CD25+ Foxp3+ Treg cells expressing the key immunomodulatory molecule CTLA-4 and a significant increase in the proportion of DCs that were plasmacytoid (CD123+), with a decrease in the myeloid/plasmacytoid DC ratio. These changes were proportional to parasite loads but correlated neither with the intensity of clinical symptoms nor with circulating cytokine levels. One-third of P. vivax-infected patients, but no P. falciparum-infected subjects, showed impaired maturation of circulating DCs, with low surface expression of CD86. Although vivax malaria patients overall had a less inflammatory cytokine response, with a higher interleukin-10 (IL-10)/tumor necrosis factor alpha (TNF-α) ratio, this finding did not translate to milder clinical manifestations than those of falciparum malaria patients. We discuss the potential implications of these findings for species-specific pathogenesis and long-lasting protective immunity to malaria.

scholarly journals The Toll-like receptor 1/2 agonists Pam3CSK4 and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes

Immunology ◽  
2011 ◽  
Vol 134 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Nicholas T. Funderburg ◽  
Julie K. Jadlowsky ◽  
Michael M. Lederman ◽  
Zhimin Feng ◽  
Aaron Weinberg ◽  
...  
Keyword(s):  
Nuclear Factor Κb ◽  
Interleukin 10 ◽  
Nuclear Factor ◽  
Human Monocytes ◽  
Toll Like Receptor

scholarly journals Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog

Virology ◽  
2009 ◽  
Vol 390 (2) ◽  
pp. 330-337 ◽  
Author(s):  
W.L. William Chang ◽  
Peter A. Barry ◽  
Richard Szubin ◽  
Dai Wang ◽  
Nicole Baumgarth
Keyword(s):  
Dendritic Cells ◽  
Human Cytomegalovirus ◽  
Type I Interferon ◽  
Interleukin 10 ◽  
Plasmacytoid Dendritic Cells ◽  
Type I

scholarly journals Role of the cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes

2008 ◽  
Vol 38 (3) ◽  
pp. 750-762 ◽  
Author(s):  
Lucia Conti ◽  
Marco Cardone ◽  
Barbara Varano ◽  
Patrizia Puddu ◽  
Filippo Belardelli ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Receptor Expression ◽  
Cytokine Receptor ◽  
Human Monocytes
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