Induction of interleukin‐10 expression through Fcα receptor in human monocytes and monocyte‐derived dendritic cells: role of p38 MAPKinase

2010 ◽  
Vol 88 (4) ◽  
pp. 486-493 ◽  
Author(s):  
Charles Pilette ◽  
Bruno Detry ◽  
Amélie Guisset ◽  
Julie Gabriels ◽  
Yves Sibille
Keyword(s):  
Dendritic Cells ◽  
Interleukin 10 ◽  
Human Monocytes

scholarly journals Role of the cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes

2008 ◽  
Vol 38 (3) ◽  
pp. 750-762 ◽  
Author(s):  
Lucia Conti ◽  
Marco Cardone ◽  
Barbara Varano ◽  
Patrizia Puddu ◽  
Filippo Belardelli ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Receptor Expression ◽  
Cytokine Receptor ◽  
Human Monocytes

Role of 4-hydroxynonenal in the hemozoin-mediated inhibition of differentiation of human monocytes to dendritic cells induced by GM-CSF/IL-4

BioFactors ◽  
2005 ◽  
Vol 24 (1-4) ◽  
pp. 283-289 ◽  
Author(s):  
Oleksii Skorokhod ◽  
Evelin Schwarzer ◽  
Tilman Grune ◽  
Paolo Arese
Keyword(s):  
Dendritic Cells ◽  
Human Monocytes ◽  
Gm Csf ◽  
Inhibition Of Differentiation

Interleukin-10 and Th2 Cytokines Differentially Regulate Osteopontin Expression in Human Monocytes and Dendritic Cells

2006 ◽  
Vol 26 (8) ◽  
pp. 562-567 ◽  
Author(s):  
Satoshi Konno ◽  
John A. Eckman ◽  
Beverly Plunkett ◽  
Xinfang Li ◽  
Jeffery S. Berman ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Interleukin 10 ◽  
Th2 Cytokines ◽  
Human Monocytes ◽  
Osteopontin Expression

Protective role of interleukin-10-producing regulatory dendritic cells against murine autoimmune gastritis

2008 ◽  
Vol 43 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Masamoto Torisu ◽  
Hidehiro Murakami ◽  
Fazle Akbar ◽  
Hidetaka Matsui ◽  
Yoichi Hiasa ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Interleukin 10 ◽  
Protective Role ◽  
Autoimmune Gastritis ◽  
Regulatory Dendritic Cells

scholarly journals TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

2009 ◽  
Vol 206 (9) ◽  
pp. 1863-1871 ◽  
Author(s):  
Frank Kaiser ◽  
Dorthe Cook ◽  
Stamatia Papoutsopoulou ◽  
Ricardo Rajsbaum ◽  
Xuemei Wu ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Types ◽  
Interleukin 10 ◽  
Interferon Β ◽  
Myeloid Dendritic Cells ◽  
Retroviral Transduction ◽  
Erk Activation ◽  
Extracellular Signal ◽  
Factor C

Stimulation of Toll-like receptors (TLRs) on macrophages and dendritic cells (DCs) by pathogen-derived products induces the production of cytokines, which play an important role in immune responses. Here, we investigated the role of the TPL-2 signaling pathway in TLR induction of interferon-β (IFN-β) and interleukin-10 (IL-10) in these cell types. It has previously been suggested that IFN-β and IL-10 are coordinately regulated after TLR stimulation. However, in the absence of TPL-2 signaling, lipopolysaccharide (TLR4) and CpG (TLR9) stimulation resulted in increased production of IFN-β while decreasing IL-10 production by both macrophages and myeloid DCs. In contrast, CpG induction of both IFN-α and IFN-β by plasmacytoid DCs was decreased in the absence of TPL-2, although extracellular signal-regulated kinase (ERK) activation was blocked. Extracellular signal-related kinase–dependent negative regulation of IFN-β in macrophages was IL-10–independent, required protein synthesis, and was recapitulated in TPL-2–deficient myeloid DCs by retroviral transduction of the ERK-dependent transcription factor c-fos.

CX3CR1 modulates the anti-inflammatory activity of hepatic dendritic cells in response to acute liver injury

2017 ◽  
Vol 131 (17) ◽  
pp. 2289-2301 ◽  
Author(s):  
Salvatore Sutti ◽  
Felix Heymann ◽  
Stefania Bruzzì ◽  
Julia Peusquens ◽  
Christian Trautwein ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Liver Injury ◽  
Hepatic Injury ◽  
Acute Liver Injury ◽  
Cell Types ◽  
Interleukin 10 ◽  
Chemokine Ligand ◽  
Anti Inflammatory

The chemokine fractalkine (C–X3–C motif chemokine ligand 1, CX3CL1) and its receptor (C–X3–C motif chemokine receptor 1, CX3CR1) are known to mediate leukocyte chemotaxis, adhesion, and survival. In the liver, CX3CR1 is expressed on multiple cell types including monocytes and dendritic cells. However, the function of CX3CR1 on hepatic dendritic cells (HDCs) is still poorly understood. In the present study, we investigated the role of CX3CR1 on mouse HDCs during homeostasis and following acute liver injury. At homeostasis, CX3CR1 expression was detected amongst CD11b+/CD103− type 2 myeloid HDCs (mHDCs) and these cells were characterized by the production of interleukin-10 (IL-10). Mice treatment with the hepatotoxic agent carbon tetrachloride (CCl4) up-regulated liver IL-10 expression and stimulated the expansion of CX3CR1+ mHDCs which also showed a more mature phenotype. The absence of CX3CR1 in naïve CX3CR1gfp/gfp mice specifically reduced the CD11b+/IL-10+ mHDCs as compared with CX3CR1-proficient animals (CX3CR1+/gfp). Following CCl4 poisoning, the liver recruitment and maturation of CD11b+ mHDCs was significantly attenuated in CX3CR1gfp/gfp mice. Furthermore, these mice suffered more severe hepatic injury and inflammation than CX3CR1+/gfp mice and showed a delated recovery from liver damage. Such a worsening of liver injury in CX3CR1gfp/gfp mice was associated with an impaired up-regulation of hepatic IL-10 expression and a lower number of IL-10 producing CD11b+ mHDCs. Consistently, IL-10 inactivation enhanced hepatic injury and inflammation in CX3CR1+/gfp mice receiving CCl4. Altogether, these data indicate a novel role of the CX3CL1/CX3CR1 axis in liver type 2 mHDC functions, pointing out the importance of CX3CR1 in promoting IL-10-mediated anti-inflammatory actions of HDCs.

scholarly journals The role of tumor necrosis factor-α for interleukin-10 production by murine dendritic cells

2011 ◽  
Vol 266 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Noriyuki Hirata ◽  
Yoshiki Yanagawa ◽  
Hisako Ogura ◽  
Masashi Satoh ◽  
Masayuki Noguchi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor
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