Inhibitors of Histone Deacetylases and DNA Methyltransferases Alter Imprinted Gene Regulation in Embryonic Stem Cells

2006 ◽  
Vol 8 (3) ◽  
pp. 200-213 ◽  
Author(s):  
Senan Baqir ◽  
Lawrence C. Smith
Keyword(s):  
Stem Cells ◽  
Gene Regulation ◽  
Embryonic Stem Cells ◽  
Histone Deacetylases ◽  
Embryonic Stem ◽  
Dna Methyltransferases ◽  
Imprinted Gene

scholarly journals 5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation

BMC Genomics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 670 ◽  
Author(s):  
Inchan Choi ◽  
Rinho Kim ◽  
Hee-Woong Lim ◽  
Klaus H Kaestner ◽  
Kyoung-Jae Won
Keyword(s):  
Stem Cells ◽  
Gene Regulation ◽  
Embryonic Stem Cells ◽  
Embryonic Stem

scholarly journals Discovery of a novel imprinted gene by transcriptional analysis of parthenogenetic embryonic stem cells

2010 ◽  
Vol 25 (8) ◽  
pp. 1927-1941 ◽  
Author(s):  
Hathaitip Sritanaudomchai ◽  
Hong Ma ◽  
Lisa Clepper ◽  
Sumita Gokhale ◽  
Randy Bogan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Transcriptional Analysis ◽  
Imprinted Gene

scholarly journals Developmental remodelling of non-CG methylation at satellite DNA repeats

2020 ◽  
Vol 48 (22) ◽  
pp. 12675-12688 ◽  
Author(s):  
Samuel E Ross ◽  
Allegra Angeloni ◽  
Fan-Suo Geng ◽  
Alex de Mendoza ◽  
Ozren Bogdanovic
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Transcriptional Repression ◽  
Dna Methyltransferase ◽  
Embryonic Stem ◽  
Dna Methyltransferases ◽  
Dna Repeats ◽  
Satellite Repeats ◽  
Cg Dinucleotides ◽  
The Brain

Abstract In vertebrates, DNA methylation predominantly occurs at CG dinucleotides however, widespread non-CG methylation (mCH) has been reported in mammalian embryonic stem cells and in the brain. In mammals, mCH is found at CAC trinucleotides in the nervous system, where it is associated with transcriptional repression, and at CAG trinucleotides in embryonic stem cells, where it positively correlates with transcription. Moreover, CAC methylation appears to be a conserved feature of adult vertebrate brains. Unlike any of those methylation signatures, here we describe a novel form of mCH that occurs in the TGCT context within zebrafish mosaic satellite repeats. TGCT methylation is inherited from both male and female gametes, remodelled during mid-blastula transition, and re-established during gastrulation in all embryonic layers. Moreover, we identify DNA methyltransferase 3ba (Dnmt3ba) as the primary enzyme responsible for the deposition of this mCH mark. Finally, we observe that TGCT-methylated repeats are specifically associated with H3K9me3-marked heterochromatin suggestive of a functional interplay between these two gene-regulatory marks. Altogether, this work provides insight into a novel form of vertebrate mCH and highlights the substrate diversity of vertebrate DNA methyltransferases.

scholarly journals Hematopoietic Differentiation of Embryonic Stem Cells: An In Vitro Model to Study Gene Regulation during Megakaryocytopoiesis

Stem Cells ◽  
1996 ◽  
Vol 14 (S1) ◽  
pp. 194-199 ◽  
Author(s):  
Georges Uzan ◽  
Marie‐Hélène Prandini ◽  
Jean‐Philippe Rosa ◽  
Rolande Berthier
Keyword(s):  
Stem Cells ◽  
Gene Regulation ◽  
Embryonic Stem Cells ◽  
In Vitro Model ◽  
Embryonic Stem ◽  
Hematopoietic Differentiation ◽  
Vitro Model ◽  
Study Gene Regulation

scholarly journals A nexus between Oct-4 and E1 A: Implications for gene regulation in embryonic stem cells

Cell ◽  
1991 ◽  
Vol 66 (2) ◽  
pp. 291-304 ◽  
Author(s):  
Hans R. Schöler ◽  
Thomas Ciesiolka ◽  
Peter Gruss
Keyword(s):  
Stem Cells ◽  
Gene Regulation ◽  
Embryonic Stem Cells ◽  
Embryonic Stem

scholarly journals Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc

PLoS ONE ◽  
2009 ◽  
Vol 4 (11) ◽  
pp. e7839 ◽  
Author(s):  
Chin-Hsing Lin ◽  
ChenWei Lin ◽  
Hisashi Tanaka ◽  
Matthew L. Fero ◽  
Robert N. Eisenman
Keyword(s):  
Stem Cells ◽  
Gene Regulation ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells ◽  
Epigenetic Remodeling
Sign in / Sign up

Export Citation Format

Share Document