scholarly journals A Source of Hydrogen Sulfide and a Mechanism of Its Release in the Brain

2009 ◽  
Vol 11 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Mari Ishigami ◽  
Keiko Hiraki ◽  
Ken Umemura ◽  
Yuki Ogasawara ◽  
Kazuyuki Ishii ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
The Brain

scholarly journals A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yong-Peng Yu ◽  
Xiang-Lin Chi ◽  
Li-Jun Liu
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion Injury ◽  
Leukocyte Adhesion ◽  
Ischemia Reperfusion ◽  
The Brain

Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. The gas H2S is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow, and leukocyte adhesion. It has been known that multiple factors, including oxidative stress, free radicals, and neuronal nitric oxide synthesis as well as abnormal inflammatory responses, are involved in the mechanism underlying the brain injury after subarachnoid hemorrhage (SAH). Based on the multiple physiologic functions of H2S, we speculate that it might be a promising, effective, and specific therapy for brain injury after SAH.

Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse

2016 ◽  
Vol 68 (5) ◽  
pp. 975-982 ◽  
Author(s):  
Xuan-li He ◽  
Ning Yan ◽  
Xiao-shan Chen ◽  
Yun-wen Qi ◽  
Yong Yan ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Transgenic Mouse ◽  
Akt Pathway ◽  
The Brain

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

2009 ◽  
Vol 11 (4) ◽  
pp. 703-714 ◽  
Author(s):  
Norihiro Shibuya ◽  
Makiko Tanaka ◽  
Mikiharu Yoshida ◽  
Yuki Ogasawara ◽  
Tadayasu Togawa ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Sulfane Sulfur ◽  
Mercaptopyruvate Sulfurtransferase ◽  
The Brain

Hydrogen Sulfide Protects the Brain Against Ischemic Reperfusion Injury in a Transient Model of Focal Cerebral Ischemia

2014 ◽  
Vol 54 (2) ◽  
pp. 264-270 ◽  
Author(s):  
Sevda Gheibi ◽  
Nahid Aboutaleb ◽  
Mehdi Khaksari ◽  
Hamid Kalalian-Moghaddam ◽  
Abedin Vakili ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Focal Cerebral Ischemia ◽  
Ischemic Reperfusion Injury ◽  
Transient Model ◽  
Ischemic Reperfusion ◽  
The Brain

scholarly journals The effects of hydrogen sulfide synthesis inhibition in lindane-induced seizures in rats: A behavioral and EEG study

2020 ◽  
Vol 72 (4) ◽  
pp. 457-463
Author(s):  
Nikola Sutulovic ◽  
Aleksandra Rasic-Markovic ◽  
Zeljko Grubac ◽  
Emilija Djuric ◽  
Dragan Hrncic
Keyword(s):  
Hydrogen Sulfide ◽  
Functional Relationship ◽  
Dependent Manner ◽  
Latency Time ◽  
Eeg Analysis ◽  
Male Wistar Rats ◽  
Generalized Epilepsy ◽  
Dose Dependent ◽  
The Brain ◽  
H2s Production

Lindane-induced seizure in rats is a model of refractory generalized epilepsy. Hydrogen sulfide (H2S) is a gasotransmitter with different physiological and pathological roles. Cystathionine-?-synthase (CBS) is a major enzyme responsible for H2S production in the brain. The aim of this study was to investigate the effects of H2S production inhibition using aminooxyacetate (a CBS inhibitor) on behavioral and EEG manifestations of lindane-induced seizures. Male Wistar rats with previously implanted EEG electrodes were intraperitoneally (i.p.) treated with 4 mg/kg lindane and observed for convulsive behavior and EEG manifestations during the next 30 min. Aminooxyacetate (5, 15 and 25 mg/kg, i.p.) or saline, was injected 30 min prior to lindane. Convulsive behavior was assessed by seizure incidence, latency time and severity (grades 0-4). The number and duration of ictal periods in the EEG were also analyzed. Seizure incidence was higher in rats treated with aminooxyacetate (AOA) before lindane, but not significantly when compared with those treated only with lindane. However, AOA significantly decreased the latency time and augmented the severity of lindane-induced seizures in a dose-dependent manner. EEG analysis revealed an increased number and duration of ictal periods in rats receiving AOA prior to lindane. H2S production inhibition aggravated lindane-induced seizures, which showed a functional relationship between H2S and the effects of lindane.

A source of hydrogen sulfide and a mechanism of its release in the brain

2009 ◽  
Vol 65 ◽  
pp. S56 ◽  
Author(s):  
Hideo Kimura ◽  
Mari Ishigami ◽  
Keiko Hiraki ◽  
Ken Umemura ◽  
Yuki Ogasawara ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
The Brain

Another pathway to produce hydrogen sulfide in the brain

2011 ◽  
Vol 71 ◽  
pp. e210
Author(s):  
Norihiro Shibuya ◽  
Mari Ishigami ◽  
Makiko Tanaka ◽  
Yuka Kimura ◽  
Yuki Ogasawara ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
The Brain

Another pathway to produce hydrogen sulfide in the brain

2010 ◽  
Vol 68 ◽  
pp. e55
Author(s):  
Norihiro Shibuya ◽  
Mari Ishigami ◽  
Makiko Tanaka ◽  
Yuka Kimura ◽  
Yuki Ogasawara ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
The Brain

scholarly journals Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 896
Author(s):  
Hideo Kimura
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Hydrogen Sulfide ◽  
Research Area ◽  
Cytoprotective Effect ◽  
Mercaptopyruvate Sulfurtransferase ◽  
Energy Formation ◽  
New Research ◽  
The Brain ◽  
Activity Energy

Since the first description of hydrogen sulfide (H2S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H2S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H2S in the brain, suggesting that H2S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H2S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H2S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H2S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H2S have been subsequently demonstrated. Two additional pathways for the production of H2S with 3-mercaptopyruvate sulfurtransferase (3MST) from l- and d-cysteine have been identified. We also discovered that hydrogen polysulfides (H2Sn, n ≥ 2) are potential signaling molecules produced by 3MST. H2Sn regulate the activity of ion channels and enzymes, as well as even the growth of tumors. S-Sulfuration (S-sulfhydration) proposed by Snyder is the main mechanism for H2S/H2Sn underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H2S/H2Sn signaling during the first 25 years.

Sign in / Sign up

Export Citation Format

Share Document