Seleno-L-Methionine Protects Against β-Amyloid and Iron/Hydrogen Peroxide-Mediated Neuron Death

2007 ◽  
Vol 9 (4) ◽  
pp. 457-467 ◽  
Author(s):  
Shuling Xiong ◽  
William R. Markesbery ◽  
Changxing Shao ◽  
Mark A. Lovell
Keyword(s):  
Hydrogen Peroxide ◽  
Neuron Death ◽  
Β Amyloid

scholarly journals Thermal cycling protects SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury through stress response mechanisms involving Akt pathway

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240022
Author(s):  
Wei-Ting Chen ◽  
Yu-Yi Kuo ◽  
Guan-Bo Lin ◽  
Chueh-Hsuan Lu ◽  
Hao-Ping Hsu ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Stress Response ◽  
Thermal Cycling ◽  
Cell Injury ◽  
Akt Pathway ◽  
Β Amyloid

scholarly journals FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

2013 ◽  
Vol 4 (5) ◽  
pp. e625-e625 ◽  
Author(s):  
P Sanphui ◽  
S C Biswas
Keyword(s):  
Neuron Death ◽  
Β Amyloid

scholarly journals The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death

2015 ◽  
Vol 134 (6) ◽  
pp. 1091-1103 ◽  
Author(s):  
Rumana Akhter ◽  
Priyankar Sanphui ◽  
Hrishita Das ◽  
Pampa Saha ◽  
Subhas Chandra Biswas
Keyword(s):  
Neuron Death ◽  
Β Amyloid ◽  
Induced Neuron

scholarly journals A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death

2013 ◽  
Vol 4 (4) ◽  
pp. e579-e579 ◽  
Author(s):  
Y Hu ◽  
X Lee ◽  
Z Shao ◽  
D Apicco ◽  
G Huang ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Neuron Death ◽  
Β Amyloid

scholarly journals Role and regulation of Cdc25A phosphatase in neuron death induced by NGF deprivation or β-amyloid

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Nandini Chatterjee ◽  
Priyankar Sanphui ◽  
Stav Kemeny ◽  
Lloyd A Greene ◽  
Subhas C Biswas
Keyword(s):  
Neuron Death ◽  
Β Amyloid ◽  
Cdc25a Phosphatase

scholarly journals Brain Trauma Induces Massive Hippocampal Neuron Death Linked to a Surge in β-Amyloid Levels in Mice Overexpressing Mutant Amyloid Precursor Protein

1998 ◽  
Vol 153 (3) ◽  
pp. 1005-1010 ◽  
Author(s):  
Douglas H. Smith ◽  
Michio Nakamura ◽  
Tracy K. McIntosh ◽  
Jun Wang ◽  
Amarís Rodríguez ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Hippocampal Neuron ◽  
Brain Trauma ◽  
Precursor Protein ◽  
Neuron Death ◽  
Β Amyloid

scholarly journals β-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species

2014 ◽  
Vol 289 (17) ◽  
pp. 12052-12062 ◽  
Author(s):  
Jennifer Mayes ◽  
Claire Tinker-Mill ◽  
Oleg Kolosov ◽  
Hao Zhang ◽  
Brian J. Tabner ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Alzheimer Disease ◽  
Amyloid Fibrils ◽  
Copper Ions ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Β Amyloid

scholarly journals Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- and diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization reaction

2014 ◽  
Vol 10 ◽  
pp. 2594-2602 ◽  
Author(s):  
László Tóth ◽  
Yan Fu ◽  
Hai Yan Zhang ◽  
Attila Mándi ◽  
Katalin E Kövér ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Conformational Analysis ◽  
Cyclization Reaction ◽  
Human Neuroblastoma ◽  
Relative Configuration ◽  
Hydride Shift ◽  
Configurational Assignment ◽  
Β Amyloid ◽  
Positive Controls

Condensed O,N-heterocycles containing tetrahydro-1,4-benzoxazepine and tetrahydroquinoline moieties were prepared by a regio- and diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization reaction of a 4-aryl-2-phenyl-1,4-benzoxazepine derivative obtained from flavanone. The relative configuration of products were determined by the correlation of 3 J H,H coupling data with the geometry of major conformers accessed by DFT conformational analysis. Separated enantiomers of the products were characterized by HPLC-ECD data, which allowed their configurational assignment on the basis of TDDFT-ECD calculation of the solution conformers. Two compounds showed neuroprotective activities against hydrogen peroxide (H2O2) or β-amyloid25–35 (Aβ25–35)-induced cellular injuries in human neuroblastoma SH-SY5Y cells in the range of those of positive controls.

scholarly journals Effect of high-frequency low-intensity pulsed electric field on protecting SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury via ERK pathway

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250491
Author(s):  
Wei-Ting Chen ◽  
Guan-Bo Lin ◽  
Yu-Yi Kuo ◽  
Chih-Hsiung Hsieh ◽  
Chueh-Hsuan Lu ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Electric Field ◽  
High Frequency ◽  
Cell Injury ◽  
Neuroprotective Effect ◽  
Specific Area ◽  
Pulsed Electric Field ◽  
Erk Pathway ◽  
Low Intensity ◽  
Β Amyloid

As the most common type of neurodegenerative diseases (NDDs), Alzheimer’s disease (AD) is thought to be caused mainly by the excessive aggregation of β-amyloid protein (Aβ). However, a growing number of studies have found that reactive oxygen species (ROS) play a key role in the onset and progression of AD. The present study aimed to probe the neuroprotective effect of high-frequency low-intensity pulsed electric field (H-LIPEF) for SH-SY5Y cells against hydrogen peroxide (H2O2) and Aβ-induced cytotoxicity. By looking in a systematic way into the frequency- and amplitude-dependent neuroprotective effect of pulsed electric field (PEF), the study finds that H-LIPEF at 200 Hz produces the optimal protective effect for SH-SY5Y cells. The underlying mechanisms were confirmed to be due to the activation of extracellular signal-regulated kinase (ERK) pathway and the downstream prosurvival and antioxidant proteins. Because the electric field can be modified to focus on specific area in a non-contact manner, the study suggests that H-LIPEF holds great potential for treating NDDs, whose effect can be further augmented with the administering of drugs or natural compounds at the same time.

Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1–10, 1–16 fragments of human and mouse β-amyloid peptide

2004 ◽  
Vol 98 (6) ◽  
pp. 940-950 ◽  
Author(s):  
Teresa Kowalik-Jankowska ◽  
Monika Ruta ◽  
Kornelia Wiśniewska ◽  
Leszek Łankiewicz ◽  
Marcin Dyba
Keyword(s):  
Hydrogen Peroxide ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Catalyzed Oxidation ◽  
Human And Mouse
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