scholarly journals The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death

2015 ◽  
Vol 134 (6) ◽  
pp. 1091-1103 ◽  
Author(s):  
Rumana Akhter ◽  
Priyankar Sanphui ◽  
Hrishita Das ◽  
Pampa Saha ◽  
Subhas Chandra Biswas
Keyword(s):  
Neuron Death ◽  
Β Amyloid ◽  
Induced Neuron

scholarly journals FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

2013 ◽  
Vol 4 (5) ◽  
pp. e625-e625 ◽  
Author(s):  
P Sanphui ◽  
S C Biswas
Keyword(s):  
Neuron Death ◽  
Β Amyloid

scholarly journals The Transient Receptor Potential Melastatin 7 (TRPM7) Inhibitors Suppress Seizure-Induced Neuron Death by Inhibiting Zinc Neurotoxicity

2020 ◽  
Vol 21 (21) ◽  
pp. 7897
Author(s):  
Jeong Hyun Jeong ◽  
Song Hee Lee ◽  
A Ra Kho ◽  
Dae Ki Hong ◽  
Dong Hyeon Kang ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Therapeutic Potential ◽  
Divalent Cations ◽  
Neurological Diseases ◽  
Receptor Potential ◽  
Neuron Death ◽  
Intracellular Zinc ◽  
Transient Receptor Potential Melastatin ◽  
Transient Receptor ◽  
Induced Neuron

Transient receptor potential melastatin 7 (TRPM7) is an ion channel that mediates monovalent cations out of cells, as well as the entry of divalent cations, such as zinc, magnesium, and calcium, into the cell. It has been reported that inhibitors of TRPM7 are neuroprotective in various neurological diseases. Previous studies in our lab suggested that seizure-induced neuronal death may be caused by the excessive release of vesicular zinc and the subsequent accumulation of zinc in the neurons. However, no studies have evaluated the effects of carvacrol and 2-aminoethoxydiphenyl borate (2-APB), both inhibitors of TRPM7, on the accumulation of intracellular zinc in dying neurons following seizure. Here, we investigated the therapeutic efficacy of carvacrol and 2-APB against pilocarpine-induced seizure. Carvacrol (50 mg/kg) was injected once per day for 3 or 7 days after seizure. 2-APB (2 mg/kg) was also injected once per day for 3 days after seizure. We found that inhibitors of TRPM7 reduced seizure-induced TRPM7 overexpression, intracellular zinc accumulation, and reactive oxygen species production. Moreover, there was a suppression of oxidative stress, glial activation, and the blood–brain barrier breakdown. In addition, inhibitors of TRPM7 remarkably decreased apoptotic neuron death following seizure. Taken together, the present study demonstrates that TRPM7-mediated zinc translocation is involved in neuron death after seizure. The present study suggests that inhibitors of TRPM7 may have high therapeutic potential to reduce seizure-induced neuron death.

Glutamate-induced neuron death requires mitochondrial calcium uptake

10.1038/1577 ◽  
1998 ◽  
Vol 1 (5) ◽  
pp. 366-373 ◽  
Author(s):  
Amy K. Stout ◽  
Heather M. Raphael ◽  
Beatriz I. Kanterewicz ◽  
Eric Klann ◽  
Ian J. Reynolds
Keyword(s):  
Calcium Uptake ◽  
Mitochondrial Calcium ◽  
Neuron Death ◽  
Induced Neuron ◽  
Mitochondrial Calcium Uptake

scholarly journals A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death

2013 ◽  
Vol 4 (4) ◽  
pp. e579-e579 ◽  
Author(s):  
Y Hu ◽  
X Lee ◽  
Z Shao ◽  
D Apicco ◽  
G Huang ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Neuron Death ◽  
Β Amyloid

scholarly journals Role and regulation of Cdc25A phosphatase in neuron death induced by NGF deprivation or β-amyloid

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Nandini Chatterjee ◽  
Priyankar Sanphui ◽  
Stav Kemeny ◽  
Lloyd A Greene ◽  
Subhas C Biswas
Keyword(s):  
Neuron Death ◽  
Β Amyloid ◽  
Cdc25a Phosphatase

scholarly journals Brain Trauma Induces Massive Hippocampal Neuron Death Linked to a Surge in β-Amyloid Levels in Mice Overexpressing Mutant Amyloid Precursor Protein

1998 ◽  
Vol 153 (3) ◽  
pp. 1005-1010 ◽  
Author(s):  
Douglas H. Smith ◽  
Michio Nakamura ◽  
Tracy K. McIntosh ◽  
Jun Wang ◽  
Amarís Rodríguez ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Hippocampal Neuron ◽  
Brain Trauma ◽  
Precursor Protein ◽  
Neuron Death ◽  
Β Amyloid
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