scholarly journals Impact of Antituberculosis Treatment on Virological Response to Highly Active Antiretroviral Therapy: Implications for Resource‐Limited Settings?

2006 ◽  
Vol 194 (10) ◽  
pp. 1467-1468 ◽  
Author(s):  
Stephen D. Lawn ◽  
Robin Wood
Keyword(s):  
Antiretroviral Therapy ◽  
Virological Response ◽  
Highly Active Antiretroviral Therapy ◽  
Resource Limited Settings ◽  
Highly Active ◽  
Resource Limited ◽  
Antituberculosis Treatment

scholarly journals Implementing a pharmacovigilance program to evaluate cutaneous adverse drug reactions in an antiretroviral access program

2012 ◽  
Vol 6 (11) ◽  
pp. 806-808
Author(s):  
Tinashe Mudzviti ◽  
Marvelous Sibanda ◽  
Samuel Gavi ◽  
Charles Chiedza Maponga ◽  
Gene D Morse
Keyword(s):  
Antiretroviral Therapy ◽  
Adverse Drug Reactions ◽  
Highly Active Antiretroviral Therapy ◽  
Family Care ◽  
Monitoring And Evaluation ◽  
Drug Reactions ◽  
Resource Limited Settings ◽  
Drug Regulatory Authority ◽  
Highly Active ◽  
Resource Limited

Introduction: Cutaneous adverse drug reactions (cADRs) can cause significant morbidity and distress in patients, especially in the HIV-infected population on antiretroviral therapy. Adverse drug reaction monitoring and ascertaining causality in resource-limited settings remain serious challenges. This study was conducted to evaluate causality and measure the incidence of cADRs in HIV-infected patients on highly active antiretroviral therapy. The study was also designed to test a three-step approach in the monitoring and evaluation of ADRs in resource-limited settings. Methodology: A retrospective review of patient medical records was performed at the Parirenyatwa Family Care Centre, Harare, Zimbabwe. Cases of cADRs were reported to the Medicines Control Authority of Zimbabwe, the main drug regulating body in Zimbabwe, for assessment and causality classification. Results: We reviewed 221 randomly selected patient records to determine whether any diagnoses of cADRs were made by clinicians. Causality assessment revealed that 13.1% of cADRs were due to an offending agent in the antiretroviral therapy versus an initial incidence of 17.6% which had been determined by the physicians. Conclusions: cADRs had an incidence of 13.1% within the population under study due to non nucleoside reverse transcriptase inhibitors (NNRTIs). Most reactions were caused by the NNRTIs which contributed 72.4 % of all cADRs. A panel of experts from the drug regulatory authority can be used as an implementation based mechanism in ascertaining causality objectively in settings where resources are constrained.

Regression of Kaposi's sarcoma lesions following highly active antiretroviral therapy in an HIV-infected patient

2008 ◽  
Vol 19 (11) ◽  
pp. 786-788 ◽  
Author(s):  
N Kumarasamy ◽  
K K Venkatesh ◽  
B Devaleenol ◽  
S Poongulali ◽  
N Ahilasamy
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Infected Patient ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Chemotherapeutic Agents ◽  
Resource Limited Settings ◽  
Infected Male ◽  
Highly Active ◽  
Resource Limited

This case report documents that highly active antiretroviral therapy (HAART) can lead to the regression of Kaposi's sarcoma (KS) lesions in the auditory canal of an HIV-infected male from Chennai, India. In resource-limited settings where administering anti-KS chemotherapeutic agents may not be feasible, HAART alone can be an option in HIV-infected individuals with KS.

The virological response to highly active antiretroviral therapy over the first 24 weeks of therapy according to the pre-therapy viral load and the weeks 4–8 viral load

AIDS ◽  
2001 ◽  
Vol 15 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Alessandro Cozzi Lepri ◽  
Veronica Miller ◽  
Andrew N. Phillips ◽  
Holger Rabenau ◽  
Caroline A. Sabin ◽  
...  
Keyword(s):  
Viral Load ◽  
Antiretroviral Therapy ◽  
Virological Response ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active
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