scholarly journals Poor Specific T Cell Responses to Human Herpesvirus 8: A Key to Unleashing Kaposi Sarcoma?

2006 ◽  
Vol 194 (8) ◽  
pp. 1030-1031 ◽  
Author(s):  
Richard F. Little ◽  
Robert Yarchoan
Keyword(s):  
T Cell ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
T Cell Responses ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Cell Responses

scholarly journals Low T Cell Responses to Human Herpesvirus 8 in Patients with AIDS‐Related and Classic Kaposi Sarcoma

2006 ◽  
Vol 194 (8) ◽  
pp. 1078-1088 ◽  
Author(s):  
Amélie Guihot ◽  
Nicolas Dupin ◽  
Anne‐Geneviève Marcelin ◽  
Isabelle Gorin ◽  
Anne‐Sophie Bedin ◽  
...  
Keyword(s):  
T Cell ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
T Cell Responses ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Cell Responses ◽  
Classic Kaposi Sarcoma

scholarly journals Regulatory T Cell Effect on CD8+T Cell Responses to Human Herpesvirus 8 Infection and Development of Kaposi's Sarcoma

2017 ◽  
Vol 33 (7) ◽  
pp. 668-674 ◽  
Author(s):  
Lauren M. Lepone ◽  
Giovanna Rappocciolo ◽  
Paolo A. Piazza ◽  
Diana M. Campbell ◽  
Frank J. Jenkins ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Kaposi's Sarcoma ◽  
Human Herpesvirus ◽  
T Cell Responses ◽  
Kaposi’S Sarcoma ◽  
Cd8 T Cell ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Cell Responses

scholarly journals CD4 regulatory T cells Control CD8 T cell responses to human Herpesvirus 8 lytic and latency proteins

2012 ◽  
Vol 7 (S1) ◽  
Author(s):  
Lauren Lepone ◽  
Giovanna Rappocciolo ◽  
Paolo Piazza ◽  
Mariel Jais ◽  
Frank J Jenkins ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Human Herpesvirus ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Cell Responses

scholarly journals Monofunctional and Polyfunctional CD8+ T Cell Responses to Human Herpesvirus 8 Lytic and Latency Proteins

2010 ◽  
Vol 17 (10) ◽  
pp. 1507-1516 ◽  
Author(s):  
Lauren Lepone ◽  
Giovanna Rappocciolo ◽  
Emilee Knowlton ◽  
Mariel Jais ◽  
Paolo Piazza ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Primary Effusion Lymphoma ◽  
Interleukin 2 ◽  
Human Herpesvirus ◽  
T Cell Responses ◽  
Human Herpesvirus 8 ◽  
Nuclear Antigen ◽  
Herpesvirus 8 ◽  
Cell Responses

ABSTRACT Human herpesvirus 8 (HHV-8) is the etiological agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. It is postulated that CD8+ T cell responses play an important role in controlling HHV-8 infection and preventing development of disease. In this study, we investigated monofunctional and polyfunctional CD8+ T cell responses to HHV-8 lytic proteins gB (glycoprotein B) and K8.1 and latency proteins LANA-1 (latency-associated nuclear antigen-1) and K12. On the basis of our previous findings that dendritic cells (DC) reveal major histocompatibility complex (MHC) class I epitopes in gB, we used a DC-based system to identify 2 novel epitopes in gB, 2 in K8.1, 5 in LANA-1, and 1 in K12. These new HHV-8 epitopes activated monofunctional and polyfunctional CD8+ T cells that produced various combinations of gamma interferon, interleukin 2, tumor necrosis factor alpha, macrophage inhibitory protein 1β, and cytotoxic degranulation marker CD107a in healthy HHV-8-seropositive individuals. We were also able to detect HHV-8-specific CD8+ T cells in peripheral blood samples using HLA A*0201 pentamer complexes for one gB epitope, one K8.1 epitope, two LANA-1 epitopes, and one K12 epitope. These immunogenic regions of viral lytic and latency proteins could be important in T cell control of HHV-8 infection.

Changes in the Immune Responses Against Human Herpesvirus-8 in the Disease Course of Posttransplant Kaposi Sarcoma

2008 ◽  
Vol 86 (5) ◽  
pp. 738-744 ◽  
Author(s):  
Patrizia Barozzi ◽  
Chiara Bonini ◽  
Leonardo Potenza ◽  
Michele Masetti ◽  
Gianni Cappelli ◽  
...  
Keyword(s):  
Immune Responses ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Disease Course ◽  
Herpesvirus 8
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