scholarly journals Successful Treatment of Kaposi Sarcoma-Associated Herpesvirus Inflammatory Cytokine Syndrome After Kidney-Liver Transplant: Correlations With the Human Herpesvirus 8 miRNome and Specific T Cell Response

2017 ◽  
Vol 17 (11) ◽  
pp. 2963-2969 ◽  
Author(s):  
A. Mularoni ◽  
A. Gallo ◽  
G. Riva ◽  
P. Barozzi ◽  
M. Miele ◽  
...  
Keyword(s):  
T Cell ◽  
Liver Transplant ◽  
Cell Response ◽  
Inflammatory Cytokine ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
T Cell Response ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Kidney Liver

Primary human herpesvirus 8 infection generates a broadly specific CD8+ T-cell response to viral lytic cycle proteins

Blood ◽  
2001 ◽  
Vol 97 (8) ◽  
pp. 2366-2373 ◽  
Author(s):  
Qiong J. Wang ◽  
Frank J. Jenkins ◽  
Lisa P. Jacobson ◽  
Lawrence A. Kingsley ◽  
Richard D. Day ◽  
...  
Keyword(s):  
T Cell ◽  
Capsid Protein ◽  
Cell Response ◽  
Human Herpesvirus ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Lytic Cycle ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Ifn Γ

Abstract Human herpesvirus 8 (HHV-8) is a recently discovered gammaherpesvirus that is the etiologic agent of Kaposi sarcoma (KS). The natural history of primary HHV-8 infection, including clinical outcome and host immune responses that may be important in preventing disease related to HHV-8, has not been elucidated. The present study characterized the clinical, immunologic, and virologic parameters of primary HHV-8 infection in 5 cases detected during a 15-year longitudinal study of 108 human immunodeficiency virus type 1 seronegative men in the Multicenter AIDS Cohort Study. Primary HHV-8 infection was associated with mild, nonspecific signs and symptoms of diarrhea, fatigue, localized rash, and lymphadenopathy. There were no alterations in numbers of CD4+ or CD8+ T cells or CD8+ T-cell interferon γ (IFN-γ) production to mitogen or nominal antigen. CD8+ cytotoxic T-lymphocyte precursor (CTLp) and IFN-γ reactivity were detected during primary HHV-8 infection, with broad specificity to 5 lytic cycle proteins of HHV-8 encoded by open reading frame 8 (ORF 8; glycoprotein B homolog of Epstein-Barr virus), ORF 22 (gH homolog), ORF 25 (major capsid protein homolog), ORF 26 (a minor capsid protein homolog), or ORF 57 (an early protein homolog), in association with increases in serum antibody titers and appearance of HHV-8 DNA in blood mononuclear cells. CD8+ T-cell responses to HHV-8 decreased by 2 to 3 years after primary infection. This antiviral T-cell response may control initial HHV-8 infection and prevent development of disease.

scholarly journals Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A

Virology ◽  
2012 ◽  
Vol 433 (1) ◽  
pp. 220-225 ◽  
Author(s):  
Kristen M. Tamburro ◽  
Dongmei Yang ◽  
Jessica Poisson ◽  
Yuri Fedoriw ◽  
Debasmita Roy ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8

scholarly journals Low T Cell Responses to Human Herpesvirus 8 in Patients with AIDS‐Related and Classic Kaposi Sarcoma

2006 ◽  
Vol 194 (8) ◽  
pp. 1078-1088 ◽  
Author(s):  
Amélie Guihot ◽  
Nicolas Dupin ◽  
Anne‐Geneviève Marcelin ◽  
Isabelle Gorin ◽  
Anne‐Sophie Bedin ◽  
...  
Keyword(s):  
T Cell ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
T Cell Responses ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Cell Responses ◽  
Classic Kaposi Sarcoma

Fatal disseminated kaposi sarcoma following human herpesvirus 8 primary infections in liver-transplant recipients

2003 ◽  
Vol 38 ◽  
pp. 48
Author(s):  
A.G. Marcelin ◽  
A.M. Roque-Afonso ◽  
M. Hurtova ◽  
Z. Ait Arkoub ◽  
M. Tulliez ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Transplant Recipients ◽  
Herpesvirus 8 ◽  
Liver Transplant Recipients
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