scholarly journals Enterotoxigenic Escherichia coli: Traveler's Diarrhea Comes Home

2006 ◽  
Vol 42 (3) ◽  
pp. 335-336 ◽  
Author(s):  
N. A. Daniels
2019 ◽  
Vol 8 (27) ◽  
Author(s):  
Denish Piya ◽  
Lauren Lessor ◽  
Mei Liu ◽  
Jason J. Gill

ABSTRACT Here, we describe the complete genome sequence of siphophage LL5. LL5 is a T1-like phage isolated against enterotoxigenic Escherichia coli, which causes traveler’s diarrhea. LL5 is included as a component phage in the commercial prebiotic product PreforPro.


1976 ◽  
Vol 3 (5) ◽  
pp. 486-495
Author(s):  
G K Morris ◽  
M H Merson ◽  
D A Sack ◽  
J G Wells ◽  
W T Martin ◽  
...  

A laboratory investigation was conducted on cultures collected from travelers before, during, and after a trip to Mexico to characterize the etiology of traveler's diarrhea. Four laboratory methods for detecting enterotoxigenicity of Escherichia coli were evaluated: the infant mouse assay, the Chinese hamster ovary (CHO) cell assay, the Y1 adrenal cell assay, and the rabbit ileal loop. Although a number of common enteric pathogens were identified as a cause of traveler's diarrhea, including six serotypes of Salmonella, two serotypes of Shigella, Vibrio parahaemolyticus, Giardia lamblia, and Entamoeba histolytica, enterotoxigenic Escherichia coli was most commonly isolated. Strains were identified that produced only heat-labile enterotoxin (LT), only heat-stable enterotoxin (ST), or both LT and ST. The infant mouse assay yielded results falling into two distinct groups, providing a clear separation of positive and negative cultures. The CHO assay also formed two groups, with positive cultures producing 11% or more of the elongated cells. There was good agreement between the CHO and the Y1 adrenal cell assays for detection of LT. The adrenal cell system for detection of LT was more suitable than the CHO assay for processing large numbers of specimens because of the miniculture modification of this method utilized in this study. The infant mouse method was a simple and reliable method for detecting ST.


2021 ◽  
Author(s):  
Bo Yang ◽  
Zheng Huang ◽  
Zhujun He ◽  
Yue Yue ◽  
Yonghua Zhou ◽  
...  

Enterotoxigenic Escherichia coli (ETEC) is the main bacterial cause for diarrhea among children in the developing countries and traveler’s diarrhea. In this study, mice model was used to evaluate the...


2019 ◽  
Vol 8 (30) ◽  
Author(s):  
Denish Piya ◽  
Lauren Lessor ◽  
Mei Liu ◽  
Jason J. Gill

This work describes the complete genome sequence of the virulent myophage LL12. The 136-kb LL12 genome is related to coliphage V5 and is a component in the prebiotic PreforPro. LL12 was isolated against enterotoxigenic Escherichia coli, which causes traveler’s diarrhea.


2012 ◽  
Vol 51 (2) ◽  
pp. 633-635 ◽  
Author(s):  
F. P. Rivera ◽  
A. M. Medina ◽  
E. Aldasoro ◽  
A. Sangil ◽  
J. Gascon ◽  
...  

2018 ◽  
Vol 63 (2) ◽  
pp. e01745-18 ◽  
Author(s):  
Elisabet Guiral ◽  
Milene Gonçalves Quiles ◽  
Laura Muñoz ◽  
Javier Moreno-Morales ◽  
Izaskun Alejo-Cancho ◽  
...  

ABSTRACT The objective of this study was to assess the antimicrobial resistance of enteroaggregative Escherichia coli (EAEC) and enterotoxigenic E. coli (ETEC) strains causing traveler’s diarrhea (TD) and to investigate the molecular characterization of antimicrobial resistance genes to third-generation cephalosporins, cephamycins, and quinolones. Overall, 39 EAEC and 43 ETEC clinical isolates were studied. The susceptibilities of EAEC and ETEC against ampicillin, amoxicillin-clavulanic acid, cefotaxime, imipenem, chloramphenicol, tetracycline, co-trimoxazole, nalidixic acid, ciprofloxacin, azithromycin, and rifaximin were determined. All genes encoding resistance determinants were detected by PCR or PCR plus DNA sequencing. The epidemiology of selected EAEC and ETEC strains was studied using multilocus sequence typing (MLST). The resistance to quinolones of EAEC and ETEC strains causing TD has significantly increased over the last decades, and high percentages have been found especially in patients traveling to India and sub-Saharan Africa. Sequence type 38 (ST38) and ST131, carrying the blaCTX-M-15 and blaCTX-M-27 genes, respectively, are highly prevalent among extended-spectrum β-lactamase (ESBL)-producing EAEC and ETEC strains. The cephamycinase ACT-20 is described in the present study for the first time in EAEC and ETEC strains causing TD in patients who had traveled to Central America. The percentages of resistance to azithromycin in EAEC and ETEC isolates from patients to Southeast Asia/India and Africa are above 25%. Meanwhile, rifaximin is still active against EAEC and ETEC, with the prevalence of resistant strains not being high. In conclusion, fluoroquinolones should no longer be considered the drugs of choice for the prevention or treatment in TD for travelers traveling to India and Africa. Azithromycin and rifaximin are still a good alternative to treat TD caused by EAEC or ETEC.


1999 ◽  
Vol 29 (2) ◽  
pp. 335-338 ◽  
Author(s):  
Mariela Glandt ◽  
Javier A. Adachi ◽  
John J. Mathewson ◽  
Zhi‐Dong Jiang ◽  
Daniel DiCesare ◽  
...  

2005 ◽  
Vol 18 (3) ◽  
pp. 465-483 ◽  
Author(s):  
Firdausi Qadri ◽  
Ann-Mari Svennerholm ◽  
A. S. G. Faruque ◽  
R. Bradley Sack

SUMMARY ETEC is an underrecognized but extremely important cause of diarrhea in the developing world where there is inadequate clean water and poor sanitation. It is the most frequent bacterial cause of diarrhea in children and adults living in these areas and also the most common cause of traveler's diarrhea. ETEC diarrhea is most frequently seen in children, suggesting that a protective immune response occurs with age. The pathogenesis of ETEC-induced diarrhea is similar to that of cholera and includes the production of enterotoxins and colonization factors. The clinical symptoms of ETEC infection can range from mild diarrhea to a severe cholera-like syndrome. The effective treatment of ETEC diarrhea by rehydration is similar to treatment for cholera, but antibiotics are not used routinely for treatment except in traveler's diarrhea. The frequency and characterization of ETEC on a worldwide scale are inadequate because of the difficulty in recognizing the organisms; no simple diagnostic tests are presently available. Protection strategies, as for other enteric infections, include improvements in hygiene and development of effective vaccines. Increases in antimicrobial resistance will dictate the drugs used for the treatment of traveler's diarrhea. Efforts need to be made to improve our understanding of the worldwide importance of ETEC.


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