scholarly journals Shiga Toxin--Producing Escherichia coli Infection

2004 ◽  
Vol 38 (9) ◽  
pp. 1298-1303 ◽  
Author(s):  
C. M. Thorpe
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Escherichia Coli Infection

Shiga toxin 2eB‐transgenic lettuce vaccine is effective in protecting weaned piglets from edema disease caused by Shiga toxin‐producing Escherichia coli infection

2019 ◽  
Vol 90 (11) ◽  
pp. 1460-1467 ◽  
Author(s):  
Takashi Hamabata ◽  
Toshio Sato ◽  
Eiji Takita ◽  
Takeshi Matsui ◽  
Taishi Imaoka ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Weaned Piglets ◽  
Transgenic Lettuce ◽  
Edema Disease ◽  
Escherichia Coli Infection

scholarly journals Haemolytic uraemic syndrome and Shiga toxin-producing Escherichia coli infection in children in France

2000 ◽  
Vol 124 (2) ◽  
pp. 215-220 ◽  
Author(s):  
B. DECLUDT ◽  
P. BOUVET ◽  
P. MARIANI-KURKDJIAN ◽  
F. GRIMONT ◽  
P. A. D. GRIMONT ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Prospective Study ◽  
Shiga Toxin ◽  
Haemolytic Uraemic Syndrome ◽  
Serum Samples ◽  
E Coli ◽  
Escherichia Coli Infection ◽  
Stool Samples ◽  
Polymerase Chain

We conducted a study to determine the incidence of haemolytic uraemic syndrome (HUS) in children in France and to assess the role of Shiga-toxin-producing Escherichia coli (STEC) infection in the aetiology of HUS. In collaboration with the Société de Néphrologie Pédiatrique we undertook a retrospective review of all cases of HUS hospitalized from January 1993 to March 1995 and a 1-year prospective study (April 1995–March 1996) of epidemiological and microbiological features of cases of HUS. The polymerase chain reaction (PCR) procedure was used to detect stx, eae, e-hlyA genes directly from case stool samples. Serum samples from cases were examined for antibodies to lipopolysaccharide (LPS) of 26 major STEC serogroups. Two hundred and eighty-six cases were reported. The average incidence per year was 0·7/105 children < 15 years and 1·8/105 children < 5 years. During the prospective study, 122/130 cases were examined for evidence of STEC infection using PCR and/or serological assays and 105 (86%) had evidence of STEC infection. Serum antibodies to E. coli O157 LPS were detected in 79 (67%) cases tested. In conclusion, this study showed that STEC infection is an important cause of HUS in children in France, with a high proportion related to the O157 serogroup.

scholarly journals Shiga Toxin-producing Escherichia coli Infection in Germany--Different Risk Factors for Different Age Groups

2006 ◽  
Vol 165 (4) ◽  
pp. 425-434 ◽  
Author(s):  
D. Werber ◽  
S. C. Behnke ◽  
A. Fruth ◽  
R. Merle ◽  
S. Menzler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Escherichia Coli ◽  
Shiga Toxin ◽  
Age Groups ◽  
Escherichia Coli Infection

scholarly journals Neuropsychological Outcome after Complicated Shiga Toxin–Producing Escherichia coli Infection

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103029 ◽  
Author(s):  
Olga Simova ◽  
Gabriele Weineck ◽  
Thorsten Schuetze ◽  
Karl Wegscheider ◽  
Ulf Panzer ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Neuropsychological Outcome ◽  
Escherichia Coli Infection

Verotoxigenic Escherichia coli Infection: U.S. Overview†

1997 ◽  
Vol 60 (11) ◽  
pp. 1466-1471 ◽  
Author(s):  
PHILLIP I. TARR ◽  
THOMAS E. BESSER ◽  
DALE D. HANCOCK ◽  
WILLIAM E. KEENE ◽  
MARCIA GOLDOFT
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Public Health Problem ◽  
The United States ◽  
Human Populations ◽  
Molecular Fingerprinting ◽  
Dna Encoding ◽  
E Coli ◽  
Escherichia Coli Infection ◽  
Toxigenic Strains

Escherichia coli O157:H7 remains a public health problem in the United States despite a dramatic increase in the awareness of, and concern about, foodborne infections since the 1993 multistate E. coli O157:H7 epidemic. Although surveillance data can be difficult to interpret, the incidence of endemic disease caused by this organism is probably not increasing, and might be decreasing, at least in selected populations. With increased recognition of E. coli O157:H7 infection has come the investigation of increasing number of outbreaks, leading to the recognition of many “new” vehicles, including some foods not traditionally associated with enteric infections, such as dry-cured salami and lettuce. Molecular fingerprinting techniques are being used to track the transmission of E. coli O157:H7 through human populations. Analysis of DNA encoding virulence factors and surface antigens suggests that diarrheagenic E. coli have evolved by acquiring large DNA fragments, with subsequent chromosomal recombination. Some Shiga toxin–producing E. coli other than E. coli O157:H7 are no doubt pathogens, but the majority of these toxigenic strains found in food are probably not virulent. More research is needed to define the characteristics that render selected Shiga toxin–producing organisms harmful to humans.

scholarly journals Protection against Shiga Toxin-Producing Escherichia coli Infection by Transcutaneous Immunization with Shiga Toxin Subunit B

2007 ◽  
Vol 15 (2) ◽  
pp. 359-366 ◽  
Author(s):  
C. Zhu ◽  
J. Yu ◽  
Z. Yang ◽  
K. Davis ◽  
H. Rios ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Protective Efficacy ◽  
Enzyme Linked Immunosorbent Assay ◽  
High Risk Population ◽  
Additional Group ◽  
Transcutaneous Immunization ◽  
Escherichia Coli Infection ◽  
Uremic Syndrome ◽  
Subunit B

ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) strains are important human food-borne pathogens. EHEC strains elaborate potent Shiga toxins (Stx1, and/or Stx2) implicated in the development of hemorrhagic colitis (HC) or hemolytic-uremic syndrome (HUS). In this report, we evaluated the immunogenicity and protective efficacy of Stx1 subunit B (StxB1) administered by transcutaneous immunization (TCI). Three groups of Dutch Belted rabbits received patches containing StxB1, StxB1 in combination with Escherichia coli heat-labile enterotoxin (LT), or LT alone. An additional group of naïve rabbits served as controls. The protective efficacy following TCI with StxB1 was assessed by challenging rabbits with a virulent Stx1-producing strain, RDEC-H19A, capable of inducing HC and HUS in rabbits. Antibodies specific to StxB1 from serum and bile samples were determined by enzyme-linked immunosorbent assay and toxin neutralization test. Rabbits immunized with StxB1 demonstrated improved weight gain and reduced Stx-induced histopathology. Rabbits receiving StxB or StxB1/LT showed a significant increase in serum immunoglobulin G titers specific to StxB1 as well as toxin neutralization titers. These data demonstrated that the StxB delivered by TCI could induce significant systemic immune responses. Thus, Stx subunit B vaccine delivered by a patch for a high-risk population may be a practical approach to prevent (and/or reduce) Stx-induced pathology.

Proposal for effective treatment of Shiga toxin-producing Escherichia coli infection in mice

2013 ◽  
Vol 65 ◽  
pp. 57-62 ◽  
Author(s):  
Muhammad Yunus Amran ◽  
Jun Fujii ◽  
Glynis L. Kolling ◽  
Sharon Y.A.M. Villanueva ◽  
Mosaburo Kainuma ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Effective Treatment ◽  
Shiga Toxin ◽  
Escherichia Coli Infection

scholarly journals Clinical and Laboratory Predictors of Shiga Toxin–Producing Escherichia coli Infection in Children With Bloody Diarrhea

2018 ◽  
Vol 7 (3) ◽  
pp. e116-e122 ◽  
Author(s):  
Ryan S McKee ◽  
Phillip I Tarr ◽  
Dennis J Dietzen ◽  
Rachit Chawla ◽  
David Schnadower
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Bloody Diarrhea ◽  
Escherichia Coli Infection
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