Clinical Features Related to Antiphospholipid Syndrome in Patients with Chronic Viral Infections (Hepatitis C Virus/HIV Infection): Description of 82 Cases

2004 ◽  
Vol 38 (7) ◽  
pp. 1009-1016 ◽  
Author(s):  
Manuel Ramos‐Casals ◽  
Ricard Cervera ◽  
Mariana Lagrutta ◽  
Francisco Medina ◽  
Mario García‐Carrasco ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hiv Infection ◽  
Clinical Features ◽  
Antiphospholipid Syndrome ◽  
Viral Infections ◽  
Chronic Viral Infections

Prevalence of hepatitis C virus infection in patients with antiphospholipid syndrome

1999 ◽  
Vol 30 (5) ◽  
pp. 770-773 ◽  
Author(s):  
Francisco José Muñoz-Rodríguez ◽  
Dolors Tàssies ◽  
Josep Font ◽  
Joan Carles Reverter ◽  
Ricard Cervera ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Antiphospholipid Syndrome ◽  
Hepatitis C Virus Infection

scholarly journals Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I

2005 ◽  
Vol 79 (5) ◽  
pp. 2689-2699 ◽  
Author(s):  
Rhea Sumpter ◽  
Yueh-Ming Loo ◽  
Eileen Foy ◽  
Kui Li ◽  
Mitsutoshi Yoneyama ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Viral Infections ◽  
Cultured Cells ◽  
Rna Replication ◽  
Rna Helicase ◽  
Hcv Rna ◽  
Helicase Domain ◽  
Replication Studies ◽  
Virus Rna

ABSTRACT Virus-responsive signaling pathways that induce alpha/beta interferon production and engage intracellular immune defenses influence the outcome of many viral infections. The processes that trigger these defenses and their effect upon host permissiveness for specific viral pathogens are not well understood. We show that structured hepatitis C virus (HCV) genomic RNA activates interferon regulatory factor 3 (IRF3), thereby inducing interferon in cultured cells. This response is absent in cells selected for permissiveness for HCV RNA replication. Studies including genetic complementation revealed that permissiveness is due to mutational inactivation of RIG-I, an interferon-inducible cellular DExD/H box RNA helicase. Its helicase domain binds HCV RNA and transduces the activation signal for IRF3 by its caspase recruiting domain homolog. RIG-I is thus a pathogen receptor that regulates cellular permissiveness to HCV replication and, as an interferon-responsive gene, may play a key role in interferon-based therapies for the treatment of HCV infection.

scholarly journals HIV Infection and Antiretroviral Therapy: Effect on Hepatitis C Virus Quasispecies Variability

2006 ◽  
Vol 193 (9) ◽  
pp. 1211-1218 ◽  
Author(s):  
Margaret C. Shuhart ◽  
Daniel G. Sullivan ◽  
Kirubeal Bekele ◽  
Robert D. Harrington ◽  
Mari M. Kitahata ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Therapy Effect

scholarly journals Clinical features of HBe antigen-positive cases of superinfection with hepatitis B virus and hepatitis C virus.

Kanzo ◽  
1994 ◽  
Vol 35 (8) ◽  
pp. 573-579
Author(s):  
Sadamu HOMMA ◽  
Kyoichiro TOSHIMA ◽  
Eisuke INADAMA ◽  
Masayuki KANEKI ◽  
Seika SHIMADA ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Features ◽  
Hbe Antigen ◽  
B Virus

scholarly journals Screening for anti HCV

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Fatima Mehboob
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Observational Study ◽  
General Practitioners ◽  
Clinical Features ◽  
Screening Strategy ◽  
Medical Ward ◽  
Hcv Infection ◽  
Hepatitis C Virus Infection

Purpose of this study is to evaluate the different indications for screening for Anti HCV. This study was carried out in outdoor and indoor department of North Medical Ward of Mayo Hospital, Lahore. This is a non-interventional observational study. Two hundred patients ELISA proved HCV infection were evaluated to find out what were the different circumstances or symptomatology when tests for HCV infection were advised. So that a screening strategy can be formed. As hepatitis C virus infection has varied presentation and clinical features, the general practitioners, physicians, dermatologists and psychiatrists should be conscious about it an advise for Anti HCV detection whenever it is suspected. Screening of the early cases is beneficial both for the patients and its relatives.

scholarly journals Prevalence of hepatitis C virus and HIV infection among injection drug users in two Mexican cities bordering the U.S

2007 ◽  
Vol 49 (3) ◽  
Author(s):  
Emily Faye White ◽  
Richard S. Garfein ◽  
Kimberly C Brouwer ◽  
Remedios Lozada ◽  
Rebeca Ramos ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hiv Infection ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
The U.S

Clinical features and prognosis in patients with hepatocellular carcinoma that developed after hepatitis C virus eradication with interferon therapy

2011 ◽  
Vol 46 (6) ◽  
pp. 799-808 ◽  
Author(s):  
Yuko Nagaoki ◽  
Hiroshi Aikata ◽  
Daisuke Miyaki ◽  
Eisuke Murakami ◽  
Yoshimasa Hashimoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Features ◽  
Interferon Therapy ◽  
Virus Eradication

scholarly journals Anticardiolipin Antibodies in Patients with Chronic Hepatitis C Virus Infection: Characterization in Relation to Antiphospholipid Syndrome

2000 ◽  
Vol 7 (2) ◽  
pp. 241-244 ◽  
Author(s):  
Josep Ordi-Ros ◽  
Julieta Villarreal ◽  
Francesc Monegal ◽  
Silvia Sauleda ◽  
Ignacio Esteban ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiphospholipid Syndrome ◽  
Clinical Manifestations ◽  
Cross Reactivity ◽  
Healthy Controls ◽  
Glycoprotein I ◽  
Chronic Hepatitis C Virus

ABSTRACT The antiphospholipid syndrome (APS) is usually defined by the association of clinical manifestations that comprise venous and/or arterial thrombosis, recurrent fetal losses, and thrombocytopenia, along with the presence of anticardiolipin (aCL) antibodies and/or lupus anticoagulant. Various infectious diseases can induce aCL; however, these antibodies are not usually associated with thrombotic events, as happens with autoimmune diseases, in which these antibodies need the presence of β2-glycoprotein I. Levels of immunoglobulin G (IgG) and IgM aCL antibodies were determined by enzyme-linked immunosorbent assay for 243 patients with chronic hepatitis C virus (HCV) infection and 100 healthy controls. Clinical events of APS, the level of β2-glycoprotein dependence of aCL, the presence of cryoglobulins and other autoantibodies, and cross-reactivity between purified aCL and HCV were evaluated. Positive results for aCL antibodies were found more frequently (3.3%) for the patients with HCV infection than for healthy controls (0%). All positive aCL antibodies were β2-glycoprotein I independent. No significant association was found between aCL antibodies and clinical manifestations of APS, neither was one found between the presence of other autoantibodies or cryoglobulins and that of aCL. Finally, no cross-reactivity between aCL antibodies and HCV antigens was observed. As previously reported, aCL antibodies seem to be an epiphenomenon, and they do not have clinical or laboratory significance in HCV patients.

Sign in / Sign up

Export Citation Format

Share Document