Chromosome Alteration in Crepis

1935 ◽  
Vol 69 (723) ◽  
pp. 383-384 ◽  
Author(s):  
Olive Swezy
Keyword(s):  
Chromosome Alteration

scholarly journals Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Elenice Ferreira Bastos ◽  
Lidiane Alice Silva ◽  
Marcelo Coelho Ramos ◽  
Glicínia Pimenta ◽  
Paulo Ivo Cortez ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Good Prognosis ◽  
Promyelocytic Leukemia ◽  
Response To Treatment ◽  
Chromosome 11 ◽  
Molecular Cytogenetic ◽  
Factors Associated ◽  
The Poor ◽  
Additional Chromosome ◽  
Chromosome Alteration

The prognostic significance of the additional abnormalities to the t(15; 17) remains controversial. We report a case of promyelocytic leukemia (APL) in a ten-year-old boy. Classical and molecular cytogenetic (FISH) studies of a bone marrow sample obtained at diagnosis revealed the presence of trisomy of chromosome 11 as an additional chromosomal abnormality to the t(15; 17). The presence of the translocation t(15; 17), the cytogenetic marker of APL, is usually associated with good response to treatment with ATRA. In this case, although the patient had risk factors associated with good prognosis, he evolved and died quickly. So it seems that the presence of the trisomy 11 may be associated with disease progression and the poor outcome. To our knowledge, this is the first reported case of t(15; 17) associated with trisomy of chromosome 11 in a child with APL.

scholarly journals Mutational signatures and chromosome alteration profiles of squamous cell carcinomas of the vulva

2018 ◽  
Vol 50 (2) ◽  
pp. e442-e442 ◽  
Author(s):  
Mi-Ryung Han ◽  
Sun Shin ◽  
Hyeon-Chun Park ◽  
Min Sung Kim ◽  
Sung Hak Lee ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Mutational Signatures ◽  
Chromosome Alteration

scholarly journals Unbalanced translocation, a major chromosome alteration causing loss of heterozygosity in human lung cancer

Oncogene ◽  
2008 ◽  
Vol 27 (35) ◽  
pp. 4788-4797 ◽  
Author(s):  
H Ogiwara ◽  
T Kohno ◽  
H Nakanishi ◽  
K Nagayama ◽  
M Sato ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Loss Of Heterozygosity ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Unbalanced Translocation ◽  
Chromosome Alteration

Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking Alkylation

Nature ◽  
1950 ◽  
Vol 166 (4235) ◽  
pp. 1112-1113 ◽  
Author(s):  
J. J. BIESELE ◽  
F. S. PHILIPS ◽  
J. B. THIERSCH ◽  
J. H. BURCHENAL ◽  
SONJA M. BUCKLEY ◽  
...  
Keyword(s):  
Cross Linking ◽  
Nitrogen Mustards ◽  
Chromosome Alteration

scholarly journals Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma

2020 ◽  
Vol 9 (7) ◽  
pp. 705-714
Author(s):  
Anne Jouinot ◽  
Juliane Lippert ◽  
Martin Fassnacht ◽  
Bruno de La Villeon ◽  
Amandine Septier ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Molecular Markers ◽  
Adrenocortical Carcinoma ◽  
Somatic Mutations ◽  
Intratumor Heterogeneity ◽  
Tissue Samples ◽  
Molecular Alterations ◽  
Prognostic Assessment ◽  
Genomic Studies ◽  
Chromosome Alteration

Background: The prognosis of adrenocortical carcinoma (ACC) is heterogeneous. Genomic studies have identified ACC subgroups characterized by specific molecular alterations, including features measured at DNA level (somatic mutations, chromosome alterations, DNA methylation), which are closely associated with outcome. The aim of this study was to evaluate intratumor heterogeneity of prognostic molecular markers at the DNA level. Methods: Two different tissue samples (primary tumor, local recurrence or metastasis) were analyzed in 26 patients who underwent surgery for primary or recurrent ACC. DNA-related biomarkers with prognostic role were investigated in frozen and paraffin-embedded samples. Somatic mutations of p53/Rb and Wnt/β-catenin pathways were assessed using next-generation sequencing (n = 26), chromosome alteration profiles were determined using SNP arrays (n = 14) and methylation profiles were determined using four-gene bisulfite pyrosequencing (n = 12). Results: Somatic mutations for ZNRF3, TP53, CTNN1B and CDKN2A were found in 7, 6, 6 and 4 patients, respectively, with intratumor heterogeneity in 8/26 patients (31%). Chromosome alteration profiles were ‘Noisy’ (numerous and anarchic alterations) in 8/14 and ‘Chromosomal’ (extended patterns of loss of heterozygosity) in 5/14 of the study samples. For these profiles, no intratumor heterogeneity was observed. Methylation profiles were hypermethylated in 5/12 and non-hypermethylated in 7/12 of the study samples. Intratumor heterogeneity of methylation profiles was observed in 2/12 patients (17%). Conclusions: Intratumor heterogeneity impacts DNA-related molecular markers. While somatic mutation can differ, prognostic DNA methylation and chromosome alteration profile seem rather stable and might be more robust for the prognostic assessment.

scholarly journals Chromosomal Changes during Experimental Evolution in Laboratory Populations of Escherichia coli

1999 ◽  
Vol 181 (4) ◽  
pp. 1360-1363 ◽  
Author(s):  
Ulfar Bergthorsson ◽  
Howard Ochman
Keyword(s):  
Escherichia Coli ◽  
Experimental Evolution ◽  
Restriction Enzymes ◽  
Short Term ◽  
E Coli ◽  
Restriction Sites ◽  
Laboratory Populations ◽  
Chromosome Alteration ◽  
Experimental Populations ◽  
Chromosomal Changes

ABSTRACT Short-term rates of chromosome evolution were analyzed in experimental populations of Escherichia coli B that had been propagated for 2,000 generations under four thermal regimens. Chromosome alterations were monitored in 24 independent populations by pulsed-field gel electrophoresis of DNA treated with five rare-cutting restriction enzymes. A total of 11 changes, 8 affecting chromosome size and 3 altering restriction sites, were observed in these populations, with none occurring in strains cultured at 37°C. Considering the changes detected in these experimental populations, the rate of chromosome alteration of E. coli is estimated to be half of that observed in experimental populations of yeast.

CONTRIBUTION A L'ETUDE CYTOTAXONOMIQUE D'ESPECES MEDITERRANEENNES D'ANEMONE ET DE LEURS HYBRIDES

1976 ◽  
Vol 18 (1) ◽  
pp. 151-168 ◽  
Author(s):  
Nicole Maïa ◽  
P. Venard
Keyword(s):  
Interspecific Hybrids ◽  
Meiotic Abnormalities ◽  
Meiotic Behavior ◽  
Statistical Comparison ◽  
Chromosomal Pair ◽  
Chromosome Alteration ◽  
Cultivated Species ◽  
Alien Cytoplasm ◽  
Tetraploid Level ◽  
Good Agreement

Statistical comparison of the caryotypes of the four Mediterranean Anemone species: A. palmata L., A. coronaria L., A. pavonina Lamk. and A. hortensis L., is based on the dispersion areas of the T/Θ and L/C parameters estimated for each chromosomal pair. Chromosome alteration has been observed in both interspecific hybrids obtained. These alterations are more marked when the genome is transferred into an alien cytoplasm. The F1 hybrid A. pavonina × A. hortensis is fertile with some meiotic abnormalities. Sterility of the A. pavonina × A. coronaria F1 hybrid is caused by the failure of pairing. Chromosomal doubling by colchicine restored fertility. Phylogenic relations as established by morphological, biochemical and caryotypic characters, as well as by meiotic behavior of interspecific hybrids, are in good agreement. The lack of introgression of new characters into the cultivated species A. coronaria is due to interspecific sterility barriers. Nevertheless, the introduction of the coronaria genome into the cytoplasm of pavonina would be a source of male-sterility at the tetraploid level.

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