scholarly journals Mutational signatures and chromosome alteration profiles of squamous cell carcinomas of the vulva

2018 ◽  
Vol 50 (2) ◽  
pp. e442-e442 ◽  
Author(s):  
Mi-Ryung Han ◽  
Sun Shin ◽  
Hyeon-Chun Park ◽  
Min Sung Kim ◽  
Sung Hak Lee ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Mutational Signatures ◽  
Chromosome Alteration

scholarly journals Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Inês Sequeira ◽  
Mamunur Rashid ◽  
Inês M. Tomás ◽  
Marc J. Williams ◽  
Trevor A. Graham ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Squamous Cell ◽  
Computational Modelling ◽  
Genomic Analysis ◽  
Squamous Cell Carcinomas ◽  
Mutational Signatures ◽  
Mutational Burden ◽  
Genomic Landscape ◽  
Human And Mouse

Abstract To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational signatures of human and mouse OSCC overlap extensively. Mutational burden is higher in moderate dysplasias and invasive SCCs than in hyperplasias and mild dysplasias, although mutations in p53, Notch1 and Fat1 occur in early lesions. Laminin-α3 mutations are associated with tumour invasiveness and Notch1 mutant tumours have an increased immune infiltrate. Computational modelling of clonal dynamics indicates that high genetic heterogeneity may be a feature of those mild dysplasias that are likely to progress to more aggressive tumours. These studies provide a foundation for exploring OSCC evolution, heterogeneity and progression.

scholarly journals Identification of novel mutational signatures in Asian oral squamous cell carcinomas associated with bacterial infections

2018 ◽  
Author(s):  
Arnoud Boot ◽  
Alvin W.T. Ng ◽  
Fui Teen Chong ◽  
Szu-Chi Ho ◽  
Willie Yu ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Bacterial Infections ◽  
Squamous Cell Carcinomas ◽  
Sequencing Data ◽  
Base Pairs ◽  
Mutational Signatures ◽  
Oral Squamous Cell Carcinomas ◽  
Mutational Spectra ◽  
Two Samples ◽  
History Of

AbstractMutational signatures can reveal the history of mutagenic processes that cells were exposed to prior to and during tumourigenesis. We expect that as-yet-undiscovered mutational processes will shed further light on mutagenesis leading to carcinogenesis. With this in mind, we analyzed the mutational spectra of 36 Asian oral squamous cell carcinomas. The mutational spectra of two samples from patients who presented with oral bacterial infections, showed novel mutational signatures. One of these novel signatures, SBS_AnT, is characterized by a preponderance of thymine mutations, strong transcriptional strand bias, and striking enrichment for adenines in the 4 base pairs 5’ of mutation sites. Examination of publicly available sequencing data revealed SBS_AnT in 25 tumours from several mucosal tissue types, all of which harbour human symbionts or are adjacent to tissues that harbour symbionts. Data in a preprint released while this manuscript was in revision strongly suggest that the bacterial compound colibactin causes SBS_AnT.

scholarly journals 302 Molecular and mutational signatures of squamous cell carcinomas in epidermolysis bullosa

2019 ◽  
Vol 139 (9) ◽  
pp. S266 ◽  
Author(s):  
S. Lu ◽  
M.E. Hess ◽  
A. Reimer ◽  
D. Castiglia ◽  
Y. He ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Epidermolysis Bullosa ◽  
Squamous Cell Carcinomas ◽  
Mutational Signatures

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

Smoking correlates with the presence of p53 mutations in squamous cell carcinomas of the head and neck (SCCHN)

1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Mutations

Pachydermoperiostosis with cutaneous squamous cell carcinomas

1998 ◽  
Vol 37 (9) ◽  
pp. 693-696 ◽  
Author(s):  
Seung-Chul Lee ◽  
Hong-Joo Moon ◽  
Deok Cho ◽  
Dong Wook Ryang ◽  
Seong Jin Kim ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas

18F-Deoxyglucose PET for the staging of oesophageal cancer

2003 ◽  
Vol 42 (03) ◽  
pp. 90-93 ◽  
Author(s):  
N. Döbert ◽  
O. Rieker ◽  
W. Kneist ◽  
St. Mose ◽  
A. Teising ◽  
...  
Keyword(s):  
Oesophageal Cancer ◽  
Squamous Cell ◽  
Distal Part ◽  
Standard Uptake Value ◽  
Squamous Cell Carcinomas ◽  
Tumour Grading ◽  
Positron Emission ◽  
Group A ◽  
The Mean ◽  
Drop Outs

SummaryAim: Evaluation of the influence of histopathologic sub-types and grading of primaries of oesophageal cancer, relative to their size and location, on the uptake of 18F-deoxyglucose (FDG) as measured by positron emission tomography (PET). Methods: 50 consecutive patients were evaluated. There were four drop-outs due to previous surgical and/or chemotherapeutical treatments and thus in 46 patients (28 squamous cell carcinomas and 18 adenocarcinomas) a pretherapeutic PET evalution of the primary including a standard uptake value (SUV) was obtained. In 42 cases data on tumour grading were available also. Results: Squamous cell carcinomas (SCC) were in 7/13/8 cases located in the proximal, medial and distal part of the oesophagus, respectively the grading was Gx in 3, G 2 in 12, G2-3 in 7, and G3 in 6 cases. The SUVmax showed a mean of 6.5 ± 2.8 (range 1.7-13.5). Adenocarcinomas (ACA) were located in the medial oesophagus in two cases and otherwise in its distal parts. Grading was Gx in one, G2 in 4, G2-3 in 3, G3 in 3, G3-4 in 3, and G4 in one case. The mean SUVmax was 5.2 ± 3.2 (range 1-13.6) and this was not significantly different from the SCC. Concerning the tumour grading there was a slight, statistically not relevant trend towards higher SUVmax in more dedifferentiated cancer. Discussion: SCC and ACA of the oesophagus show no relevant differences in the FDG-uptake. While there was a significant variability of tumour uptake in the overall study group, a correlation of SUV and tumour grading was not found.

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