scholarly journals THE RELATIVE PRESSURES WITHIN CUTANEOUS LYMPHATIC CAPILLARIES AND THE TISSUES

1947 ◽  
Vol 86 (4) ◽  
pp. 293-308 ◽  
Author(s):  
Philip D. McMaster

The pressure in the cutaneous lymphatic capillaries of normal mice anesthetized with nembutal ranged between 0.0 and 2.7 cm. of water. Measurements of the interstitial pressure in the tissue immediately next the lymphatics showed that, in more than half the instances studied, there was a slight gradient of pressure from the tissues to the lymph. In nearly all the other instances the pressures inside and outside the lymphatic capillaries were approximately equal. In two cases in which lymph flow in the capillaries was rapid, the lymph pressure may have been negative. Under these circumstances there must have been a considerable gradient of pressure from the tissues to the lymph. In skin which was rapidly becoming, or had recently become, edematous as result of the application of xylol or of heat, the intralymphatic capillary pressure generally was increased, yet when compared with the pressure prevailing in the edema fluid outside of the capillaries it was usually found to be relatively much lower, at times by as much as 5.9 cm. of water. The findings indicate that a pressure gradient is an important factor in lymph formation under normal and pathological circumstances.

1981 ◽  
Vol 59 (8) ◽  
pp. 786-789 ◽  
Author(s):  
J. A. Barrowman ◽  
M. A. Perry ◽  
P. R. Kvietys ◽  
M. Ulrich ◽  
D. N. Granger

Bradykinin (50 μg∙L−1) increases intestinal lymph flow sixfold when infused intraarterially into the cat ileum. The capillary filtration coefficient and capillary pressure increase and interstitial fluid pressure rises from negative to positive values. A slight increase in lymph:plasma protein concentration occurs with a resulting fall in the transcapillary oncotic pressure gradient. These results indicate that the effect of bradykinin on intestinal lymph flow is attributable, at least in part, to increased capillary pressure, exchange vessel surface area, and a reduction in the effective transcapillary oncotic pressure gradient.


2018 ◽  
Vol 63 (5) ◽  
pp. 199-202 ◽  
Author(s):  
V. A. Shargatov ◽  
G. G. Tsypkin ◽  
Yu. A. Bogdanova

2011 ◽  
pp. 63-69
Author(s):  
James R. Munis

We tend to assume that when 2 things are associated with each other, one must be causing the other. Nothing could be further from the truth, though. Because we're used to seeing the independent variable (‘cause’) plotted on the x-axis and the dependent variable (‘effect’) on the y-axis, this equation and graph suggest that the pressure gradient causes the paddle wheel flow rate. That, of course, is nonsense. This type of specious thinking is intended to warn you away from assuming that relationships necessarily imply causality. As you've learned already, pressure is not the same thing as energy, and pressure by itself cannot perform work or generate flow. However, flow generated by pressure-volume work (either by the heart or a mechanical pump) certainly can create pressure gradients. In this sort of chicken (flow) or egg (pressure) question, if the only energy-containing term is flow, then I'll say that the chicken came first.


SPE Journal ◽  
2019 ◽  
Vol 25 (01) ◽  
pp. 451-464 ◽  
Author(s):  
Swej Y. Shah ◽  
Herru As Syukri ◽  
Karl-Heinz Wolf ◽  
Rashidah M. Pilus ◽  
William R. Rossen

Summary Foam reduces gas mobility and can help improve sweep efficiency in an enhanced-oil-recovery (EOR) process. For the latter, long-distance foam propagation is crucial. In porous media, strong foam generation requires that the local pressure gradient exceed a critical value (▿Pmin). Normally, this happens only in the near-well region. Away from wells, these requirements might not be met, and foam propagation is uncertain. It has been shown theoretically that foam can be generated, independent of pressure gradient, during flow across an abrupt increase in permeability (Rossen 1999). The objective of this study is to validate theoretical explanations through experimental evidence and to quantify the effect of fractional flow on this process. This article is an extension of a recent study (Shah et al. 2018) investigating the effect of permeability contrast on this process. In this study, the effects of fractional flow and total superficial velocity are described. Coreflood experiments were performed in a cylindrical sintered-glass porous medium with two homogeneous layers and a sharp permeability jump in between, representing a lamination or cross lamination. Unlike previous studies of this foam-generation mechanism, in this study, gas and surfactant solution were coinjected at field-like velocities into a medium that was first flooded to steady state with gas/brine coinjection. The pressure gradient is measured across several sections of the core. X-ray computed tomography (CT) is used to generate dynamic phase-saturation maps as foam generates and propagates through the core. We investigate the effects of velocity and injected-gas fractional flow on foam generation and mobilization by systematically changing these variables through multiple experiments. The core is thoroughly cleaned after each experiment to remove any trapped gas and to ensure no hysteresis. Local pressure measurements and CT-based saturation maps confirm that foam is generated at the permeability transition, and it then propagates downstream to the outlet of the core. A significant reduction in gas mobility is observed, even at low superficial velocities. Foam was generated in all cases, at all the injected conditions tested; however, at the lowest velocity tested, strong foam did not propagate all the way to the outlet of the core. Although foam generation was triggered across the permeability boundary at this velocity, it appeared that, for our system, the limit of foam propagation, in terms of a minimum-driving-force requirement, was reached at this low rate. CT images were used to quantify the accumulation of liquid near the permeability jump, causing local capillary pressure to fall below the critical capillary pressure required for snap-off. This leads to foam generation by snap-off. At the tested fractional flows, no clear trend was observed between foam strength and fg. For a given permeability contrast, foam generation was observed at higher gas fractions than predicted by previous work (Rossen 1999). Significant fluctuations in pressure gradient accompanied the process of foam generation, indicating a degree of intermittency in the generation rate—probably reflecting cycles of foam generation, dryout, imbibition, and then generation. The intermittency of foam generation was found to increase with decreasing injection velocities and increasing fractional flow. Within the range of conditions tested, the onset of foam generation (identified by the rise in ▿P and Sg) occurs after roughly the same amount of surfactant injection, independent of fractional flow or injection rate.


1993 ◽  
Vol 75 (1) ◽  
pp. 268-272 ◽  
Author(s):  
M. R. Glucksberg ◽  
J. Bhattacharya

We report the first direct measurements of the effect of pulmonary vascular pressures on perialveolar interstitial pressures. In seven experiments we varied the intravascular pressure (Pvas) in isolated dog lungs held at constant airway pressure (PA). By the micropuncture servo-null technique, we recorded perialveolar interstitial pressures with respect to pleural pressure (0 cmH2O) at the alveolar junctions (Pjct) and in microvascular adventitia (Padv). At PA = 7 cmH2O, increase from 5 to 15 cmH2O did not affect Pjct, although it decreased Padv by 1.2 +/- 0.4 cmH2O. The Pjct-Padv gradient increased by 77%. Increasing Pvas to 25 cmH2O had no further effect on either interstitial pressure. In four experiments we also determined interstitial pressure in the hilum (Phil). When Pvas was increased from 5 to 15 cmH2O, Phil increased by 4.5 +/- 0.9 cmH2O. Further elevation of Pvas to 25 cmH2O increased Phil further by 2.4 +/- 0.4 cmH2O. At PA = 15 cmH2O, all interstitial pressures decreased, but their responses to Pvas were similar. We conclude that increase of Pvas 1) increases Phil but not perialveolar interstitial pressures and 2) increases the perialveolar interstitial pressure gradient, which may promote local liquid clearance.


2013 ◽  
Vol 13 (12) ◽  
pp. 3271-3279 ◽  
Author(s):  
A. Bartzokas ◽  
C. J. Lolis ◽  
P. A. Kassomenos ◽  
G. R. McGregor

Abstract. The climate characteristics of summer human thermal discomfort in Athens and its connection to atmospheric circulation are studied for the period 1954–2012. The human thermal discomfort is examined in terms of the Predicted Mean Vote (PMV) discomfort index for calm and light wind (3 ms-1) conditions. Its inter-annual variability is characterised by a significant increase from the middle 1980s to the end of the study period. The onset and the cessation of the discomfort period are found to take place around the beginning of July and the end of August respectively, but from middle 1980s the dates of onset and cessation have slightly moved earlier and later, respectively, leading to a longer summer discomfort period. The connection between human thermal discomfort and atmospheric circulation is studied by examining the distribution of discomfort cases across six objectively defined circulation types over Europe, based on Athens weather characteristics. High values of the PMV discomfort index are mainly associated with two typical high-summer pressure patterns with the intensity of discomfort depending on the pressure gradient over the Aegean Sea. On the contrary, low PMV discomfort index values prevail mainly on days typified by the other four circulation types, which are more frequent during May, June, and September.


1988 ◽  
Vol 254 (3) ◽  
pp. G339-G345 ◽  
Author(s):  
R. J. Korthuis ◽  
D. A. Kinden ◽  
G. E. Brimer ◽  
K. A. Slattery ◽  
P. Stogsdill ◽  
...  

The impact of acute and chronic portal hypertension on the dynamics of intestinal microvascular fluid exchange was examined in anesthetized, fasted, sham-operated control rats with normal portal pressures (CON), during acute elevations in portal pressure (APH) in control rats, and in rats in which chronic portal hypertension (CPH) was produced by calibrated stenosis of the portal vein 10 days prior to the experiments. Although intestinal blood flow and vascular resistance were not altered by APH in control rats, CPH was associated with an increased intestinal blood flow and reduced intestinal vascular resistance when compared with CON and APH. Intestinal capillary pressure and lymph flow were elevated in APH and CPH relative to control values. However, the increase in both variables was greater in CPH. The capillary filtration coefficient was elevated only in CPH. The transcapillary oncotic pressure gradient was not altered by APH or CPH. Interstitial fluid pressure was increased from -1.1 mmHg in CON to 3.9 mmHg during APH and to 5.0 mmHg in CPH. The results of this study indicate that chronic elevations in portal venous pressure produce larger increments in intestinal capillary pressure and filtration rate than do acute elevations in portal venous pressure of the same magnitude. However, the potential edemagenic effects of elevated capillary pressure in both acute and chronic portal hypertension are opposed by increases in lymph flow and interstitial fluid pressure.


2012 ◽  
Vol 616-618 ◽  
pp. 964-969 ◽  
Author(s):  
Yue Yang ◽  
Xiang Fang Li ◽  
Ke Liu Wu ◽  
Meng Lu Lin ◽  
Jun Tai Shi

Oil and water relative permeabilities are main coefficients in describing the fluid flow in porous media; however, oil and water relative permeability for low - ultra low perm oil reservoir can not be obtained from present correlations. Based on the characteristics of oil and water flow in porous media, the model for calculating the oil and water relative permeability of low and ultra-low perm oil reservoirs, which considering effects of threshold pressure gradient and capillary pressure, has been established. Through conducting the non-steady oil and water relative permeability experiments, oil and water relative permeability curves influenced by different factors have been calculated. Results show that: the threshold pressure gradient more prominently affects the oil and water relative permeability; capillary pressure cannot influence the water relative permeability but only the oil relative permeability. Considering effects of threshold pressure gradient and capillary pressure yields the best development result, and more accordant with the flow process of oil and water in low – ultra low perm oil reservoirs.


1962 ◽  
Vol 2 (02) ◽  
pp. 185-193 ◽  
Author(s):  
E.E. Templeton ◽  
R.F. Nielsen ◽  
C.D. Stahl

Abstract It has been customary, in predicting saturation changes, to use the Leverett "fractional flow formula", obtained by eliminating the unknown pressure gradient from the generalized Darcy equations for the separate phases. The formula presents difficulties in the case of counterflow, since the "fractional" flow may be negative, greater than unity, or, in the case of a closed system, infinite. Recently, it has been shown by several authors that the corresponding equations (with capillary pressure and gravity terms) for actual flow of the phase may be used just as well. These equations are in agreement with Pirson's statement that, if the two mobilities differ considerably from each other in a closed system, the flow is largely governed by the lower value. The present study was undertaken because of an apparent lack of experimental data on gravity counterflow with which to test the theory. A 4-ft sandpacked tube in a vertical position was employed. Electrodes for determining saturations by resistivity were spaced along the tube, one phase being always an aqueous salt solution. Air, heptane, naphtha, or Bradford crude oil was used for the other phase. A reasonably uniform initial saturation was set up by pumping the phases through the system, after which the tube was shut in and saturation profiles obtained at definite intervals. Cumulative flows over certain horizontal levels were obtained by integration of the distributions; hence, differentiation of the cumulative flows with respect to time gave instantaneous flow rates. To compare experimental and theoretical flow values, capillary pressures were assumed given by the final saturation-distribution curve. The upper part corresponds to the "drainage" region and the lower part to the "imbibition" region, where trapping of the nonwetting phase occurred. While calculations indicated that the capillary pressure saturation function and, probably, the relative permeability saturation functions changed during the segregation, the relation of the measured rates to saturation distributions are in general accord with the frontal-advance equation. It appears that the Darcy equations, as modified for the separate phases, are generally valid for counterflow due to density differences. The usual method of predicting saturation changes, which involves a continuity equation and the elimination of the unknown pressure gradient from the flow equations, should therefore be applicable. However, the need for advance knowledge of drainage and imbibition "capillary pressures" and relative permeabilities during various stages presents difficulties. Introduction The present study was undertaken because of a seeming lack of experimental data relating to vertical counterflow of fluids of different densities in porous media. In particular, it was desired to determine whether data obtained from these laboratory tests were in accordance with certain mathematical treatments of counterflow which have been proposed. The gravity "correction" has been incorporated into the flow equations (and, hence, into displacement theory) nearly as long as both have been used. Field and laboratory data have generally borne out the validity of the theory as applied, for instance, to downward displacement by gas, with all fluids moving downward. However, the modifications for counterflow have only recently been pointed out. It has been customary to use fractional flow rates instead of actual flow rates in displacement calculations. In the case of counterflow, this results in negative values, values greater than unity and, when rates are equal and opposite, in infinite values. As pointed out by Sheldon, et al, and by Fayers and Sheldon, actual flow rates may be used just as well. The fact that these may be of opposite signs for the two fluids does not present any difficulty. SPEJ P. 185^


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