scholarly journals Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes

2004 ◽  
Vol 199 (12) ◽  
pp. 1631-1640 ◽  
Author(s):  
Melissa W. Boulé ◽  
Courtney Broughton ◽  
Fabienne Mackay ◽  
Shizuo Akira ◽  
Ann Marshak-Rothstein ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Cell Activation ◽  
Critical Role ◽  
Adaptive Immune Response ◽  
Foreign Protein ◽  
Interleukin 12 ◽  
Toll Like Receptor ◽  
Dendritic Cell Activation

Dendritic cell (DC) activation by nucleic acid–containing immunoglobulin (Ig)G complexes has been implicated in systemic lupus erythematosus (SLE) pathogenesis. However, the mechanisms responsible for activation and subsequent disease induction are not completely understood. Here we show that murine DCs are much more effectively activated by immune complexes that contain IgG bound to chromatin than by immune complexes that contain foreign protein. Activation by these chromatin immune complexes occurs by two distinct pathways. One pathway involves dual engagement of the Fc receptor FcγRIII and Toll-like receptor (TLR)9, whereas the other is TLR9 independent. Furthermore, there is a characteristic cytokine profile elicited by the chromatin immune complexes that distinguishes this response from that of conventional TLR ligands, notably the induction of BAFF and the lack of induction of interleukin 12. The data establish a critical role for self-antigen in DC activation and explain how the innate immune system might drive the adaptive immune response in SLE.

scholarly journals Plasmacytoid dendritic cell activation by foot-and-mouth disease virus requires immune complexes

2006 ◽  
Vol 36 (7) ◽  
pp. 1674-1683 ◽  
Author(s):  
Laurence Guzylack-Piriou ◽  
Fabio Bergamin ◽  
Markus Gerber ◽  
Kenneth C. McCullough ◽  
Artur Summerfield
Keyword(s):  
Dendritic Cell ◽  
Disease Virus ◽  
Immune Complexes ◽  
Cell Activation ◽  
Plasmacytoid Dendritic Cell ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Dendritic Cell Activation ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology

2007 ◽  
Vol 9 (14-15) ◽  
pp. 1606-1613 ◽  
Author(s):  
François Vanhoutte ◽  
Laetitia Breuilh ◽  
Josette Fontaine ◽  
Claudia S. Zouain ◽  
Thierry Mallevaey ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Schistosoma Mansoni ◽  
Cell Activation ◽  
Toll Like Receptor ◽  
Dendritic Cell Activation

scholarly journals Deletion of the Mucin-Like Molecule Muc1 Enhances Dendritic Cell Activation in Response to Toll-Like Receptor Ligands

2010 ◽  
Vol 2 (2) ◽  
pp. 123-143 ◽  
Author(s):  
Marc A. Williams ◽  
Stephen Bauer ◽  
Wenju Lu ◽  
Jia Guo ◽  
Scott Walter ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Activation ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
Dendritic Cell Activation

scholarly journals Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes

2009 ◽  
Vol 183 (5) ◽  
pp. 3109-3117 ◽  
Author(s):  
Kei Yasuda ◽  
Christophe Richez ◽  
Melissa B. Uccellini ◽  
Rocco J. Richards ◽  
Ramon G. Bonegio ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Immune Complexes ◽  
Cell Activation ◽  
Dendritic Cell Activation

Magnoliae Flos Essential Oil as an Immunosuppressant in Dendritic Cell Activation and Contact Hypersensitivity Responses

2020 ◽  
Vol 48 (03) ◽  
pp. 597-613 ◽  
Author(s):  
Chun-Hsien Chen ◽  
Hsin-Chun Chen ◽  
Wen-Te Chang ◽  
Meng-Shiou Lee ◽  
Yi-Chen Liu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Cell Activation ◽  
Nasal Congestion ◽  
Critical Role ◽  
Adaptive Immune Response ◽  
Contact Hypersensitivity ◽  
Dendritic Cell Activation ◽  
Chinese Texts

Magnoliae Flos is a commonly used traditional medicinal material in Asia. It is used to treat sinusitis, nasal congestion, and hypersensitive skin. Because Magonlia Flos was described as an aromatic material in ancient Chinese texts, we hypothesized that its essential oil may be used to treat immune disorders. Dendritic cells (DCs), regarded as a major target of immunomodulators to control immune responses, play a critical role in the adaptive immune response. In this study, Magnoliae Flos essential oil (MFEO) decreased the production of the cytokines TNF-[Formula: see text], IL-6, and IL-12p70 in lipopolysaccharide (LPS)-stimulated DCs. It also suppressed the surface markers MHC II, CD80, and CD86 in LPS-stimulated DCs. Animal models demonstrated that the 2,4-Dinitro-1-fluorobenzene (DNFB) inducing a contact hypersensitivity response was inhibited following treatment with MFEO. In addition, MFEO inhibited the infiltration of T cells in the ears of DNFB-induced mice. To explore its bioactive compounds, the components of MFEO were analyzed using gas chromatography (GC) and GC-mass spectrometry. The results revealed that the major compounds in MFEO are camphor and 1,8-cineole. Additional DC bioassays confirmed that these compounds substantially suppressed cytokine production in LPS-induced DCs. Therefore, we demonstrated that MFEO exhibits an immunosuppressive effect both in vivo and in vitro, and camphor and 1,8-cineole may be the major components responsible for its immunosuppressive ability. The findings indicate that MFEO has the potential to be developed as a new immunosuppressant for excessive diseases.

Synergistic effects of chemical insult and toll-like receptor ligands on dendritic cell activation

2008 ◽  
Vol 22 (8) ◽  
pp. 1927-1934 ◽  
Author(s):  
Rebecca J. Dearman ◽  
Marie Cumberbatch ◽  
Craig Portsmouth ◽  
Gavin Maxwell ◽  
David A. Basketter ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Activation ◽  
Synergistic Effects ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
Dendritic Cell Activation
Sign in / Sign up

Export Citation Format

Share Document