scholarly journals Deletion of the Mucin-Like Molecule Muc1 Enhances Dendritic Cell Activation in Response to Toll-Like Receptor Ligands

2010 ◽  
Vol 2 (2) ◽  
pp. 123-143 ◽  
Author(s):  
Marc A. Williams ◽  
Stephen Bauer ◽  
Wenju Lu ◽  
Jia Guo ◽  
Scott Walter ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Activation ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
Dendritic Cell Activation

Synergistic effects of chemical insult and toll-like receptor ligands on dendritic cell activation

2008 ◽  
Vol 22 (8) ◽  
pp. 1927-1934 ◽  
Author(s):  
Rebecca J. Dearman ◽  
Marie Cumberbatch ◽  
Craig Portsmouth ◽  
Gavin Maxwell ◽  
David A. Basketter ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Activation ◽  
Synergistic Effects ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
Dendritic Cell Activation

Synergistic effect of chemical insult and toll-like receptor ligands on dendritic cell activation

2006 ◽  
Vol 164 ◽  
pp. S215 ◽  
Author(s):  
Ian Kimber ◽  
Marie Cumberbatch ◽  
Craig Portsmouth ◽  
Kirsty Clelland ◽  
Carolin Schramm ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Synergistic Effect ◽  
Cell Activation ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
Dendritic Cell Activation

scholarly journals Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes

2004 ◽  
Vol 199 (12) ◽  
pp. 1631-1640 ◽  
Author(s):  
Melissa W. Boulé ◽  
Courtney Broughton ◽  
Fabienne Mackay ◽  
Shizuo Akira ◽  
Ann Marshak-Rothstein ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Cell Activation ◽  
Critical Role ◽  
Adaptive Immune Response ◽  
Foreign Protein ◽  
Interleukin 12 ◽  
Toll Like Receptor ◽  
Dendritic Cell Activation

Dendritic cell (DC) activation by nucleic acid–containing immunoglobulin (Ig)G complexes has been implicated in systemic lupus erythematosus (SLE) pathogenesis. However, the mechanisms responsible for activation and subsequent disease induction are not completely understood. Here we show that murine DCs are much more effectively activated by immune complexes that contain IgG bound to chromatin than by immune complexes that contain foreign protein. Activation by these chromatin immune complexes occurs by two distinct pathways. One pathway involves dual engagement of the Fc receptor FcγRIII and Toll-like receptor (TLR)9, whereas the other is TLR9 independent. Furthermore, there is a characteristic cytokine profile elicited by the chromatin immune complexes that distinguishes this response from that of conventional TLR ligands, notably the induction of BAFF and the lack of induction of interleukin 12. The data establish a critical role for self-antigen in DC activation and explain how the innate immune system might drive the adaptive immune response in SLE.

Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology

2007 ◽  
Vol 9 (14-15) ◽  
pp. 1606-1613 ◽  
Author(s):  
François Vanhoutte ◽  
Laetitia Breuilh ◽  
Josette Fontaine ◽  
Claudia S. Zouain ◽  
Thierry Mallevaey ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Schistosoma Mansoni ◽  
Cell Activation ◽  
Toll Like Receptor ◽  
Dendritic Cell Activation
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