scholarly journals Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes

2009 ◽  
Vol 183 (5) ◽  
pp. 3109-3117 ◽  
Author(s):  
Kei Yasuda ◽  
Christophe Richez ◽  
Melissa B. Uccellini ◽  
Rocco J. Richards ◽  
Ramon G. Bonegio ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Immune Complexes ◽  
Cell Activation ◽  
Dendritic Cell Activation

scholarly journals Plasmacytoid dendritic cell activation by foot-and-mouth disease virus requires immune complexes

2006 ◽  
Vol 36 (7) ◽  
pp. 1674-1683 ◽  
Author(s):  
Laurence Guzylack-Piriou ◽  
Fabio Bergamin ◽  
Markus Gerber ◽  
Kenneth C. McCullough ◽  
Artur Summerfield
Keyword(s):  
Dendritic Cell ◽  
Disease Virus ◽  
Immune Complexes ◽  
Cell Activation ◽  
Plasmacytoid Dendritic Cell ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Dendritic Cell Activation ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes

2004 ◽  
Vol 199 (12) ◽  
pp. 1631-1640 ◽  
Author(s):  
Melissa W. Boulé ◽  
Courtney Broughton ◽  
Fabienne Mackay ◽  
Shizuo Akira ◽  
Ann Marshak-Rothstein ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Cell Activation ◽  
Critical Role ◽  
Adaptive Immune Response ◽  
Foreign Protein ◽  
Interleukin 12 ◽  
Toll Like Receptor ◽  
Dendritic Cell Activation

Dendritic cell (DC) activation by nucleic acid–containing immunoglobulin (Ig)G complexes has been implicated in systemic lupus erythematosus (SLE) pathogenesis. However, the mechanisms responsible for activation and subsequent disease induction are not completely understood. Here we show that murine DCs are much more effectively activated by immune complexes that contain IgG bound to chromatin than by immune complexes that contain foreign protein. Activation by these chromatin immune complexes occurs by two distinct pathways. One pathway involves dual engagement of the Fc receptor FcγRIII and Toll-like receptor (TLR)9, whereas the other is TLR9 independent. Furthermore, there is a characteristic cytokine profile elicited by the chromatin immune complexes that distinguishes this response from that of conventional TLR ligands, notably the induction of BAFF and the lack of induction of interleukin 12. The data establish a critical role for self-antigen in DC activation and explain how the innate immune system might drive the adaptive immune response in SLE.

scholarly journals Hierarchical requirement for CpG Motifs in dendritic cell activation induced by DNA‐containing immune‐complexes

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Kei Yasuda ◽  
Melissa B. Uccellini ◽  
Christophe Richez ◽  
Gregory A Viglianti ◽  
Shizuo Akira ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Immune Complexes ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
Cpg Motifs

scholarly journals Laser nanobubbles induce immunogenic cell death in breast cancer

Nanoscale ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 3644-3653
Author(s):  
Hieu T. M. Nguyen ◽  
Nitesh Katta ◽  
Jessica A. Widman ◽  
Eri Takematsu ◽  
Xu Feng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Dendritic Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cell Activation ◽  
Immunogenic Cell Death ◽  
Dendritic Cell Activation

Laser nanobubbles induce dendritic cell activation in breast cancer cells.

scholarly journals Staphylococcus aureus-Induced Plasmacytoid Dendritic Cell Activation Is Based on an IgG-Mediated Memory Response

2008 ◽  
Vol 181 (6) ◽  
pp. 3823-3833 ◽  
Author(s):  
Marijo Parcina ◽  
Constanze Wendt ◽  
Friedrich Goetz ◽  
Rainer Zawatzky ◽  
Ulrich Zähringer ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Dendritic Cell ◽  
Cell Activation ◽  
Plasmacytoid Dendritic Cell ◽  
Dendritic Cell Activation ◽  
Memory Response
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