2′-BIS-PYRENE MODIFIED OLIGONUCLEOTIDES: SENSITIVE FLUORESCENT PROBES OF NUCLEIC ACIDS STRUCTURE

2005 ◽  
Vol 24 (5-7) ◽  
pp. 729-734 ◽  
Author(s):  
D. S. Novopashina ◽  
D. A. Stetsenko ◽  
O. S. Totskaya ◽  
M. N. Repkova ◽  
A. G. Venyaminova
Keyword(s):  
Nucleic Acids ◽  
Fluorescent Probes ◽  
Modified Oligonucleotides

scholarly journals Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 628
Author(s):  
Dagmara Baraniak ◽  
Jerzy Boryski
Keyword(s):  
Nucleic Acids ◽  
State Of The Art ◽  
Modified Oligonucleotides ◽  
Synthetic Genes ◽  
Chemically Modified ◽  
Amide Linkage ◽  
Dna And Rna ◽  
Modified Dna ◽  
Modified Nucleic Acids ◽  
Non Coding Rnas

This review covers studies which exploit triazole-modified nucleic acids in the range of chemistry and biology to medicine. The 1,2,3-triazole unit, which is obtained via click chemistry approach, shows valuable and unique properties. For example, it does not occur in nature, constitutes an additional pharmacophore with attractive properties being resistant to hydrolysis and other reactions at physiological pH, exhibits biological activity (i.e., antibacterial, antitumor, and antiviral), and can be considered as a rigid mimetic of amide linkage. Herein, it is presented a whole area of useful artificial compounds, from the clickable monomers and dimers to modified oligonucleotides, in the field of nucleic acids sciences. Such modifications of internucleotide linkages are designed to increase the hybridization binding affinity toward native DNA or RNA, to enhance resistance to nucleases, and to improve ability to penetrate cell membranes. The insertion of an artificial backbone is used for understanding effects of chemically modified oligonucleotides, and their potential usefulness in therapeutic applications. We describe the state-of-the-art knowledge on their implications for synthetic genes and other large modified DNA and RNA constructs including non-coding RNAs.

Exciton-Controlled Hybridization-Sensitive Fluorescent Probes: Multicolor Detection of Nucleic Acids

2009 ◽  
Vol 48 (35) ◽  
pp. 6480-6484 ◽  
Author(s):  
Shuji Ikeda ◽  
Takeshi Kubota ◽  
Mizue Yuki ◽  
Akimitsu Okamoto
Keyword(s):  
Nucleic Acids ◽  
Fluorescent Probes

Exciton-Controlled Hybridization-Sensitive Fluorescent Probes: Multicolor Detection of Nucleic Acids

2009 ◽  
Vol 121 (35) ◽  
pp. 6602-6606 ◽  
Author(s):  
Shuji Ikeda ◽  
Takeshi Kubota ◽  
Mizue Yuki ◽  
Akimitsu Okamoto
Keyword(s):  
Nucleic Acids ◽  
Fluorescent Probes

Zinc complexes as fluorescent chemosensors for nucleic acids: new perspectives for a “boring” element

2015 ◽  
Vol 44 (8) ◽  
pp. 3527-3535 ◽  
Author(s):  
Alessio Terenzi ◽  
Antonino Lauria ◽  
Anna Maria Almerico ◽  
Giampaolo Barone
Keyword(s):  
Nucleic Acids ◽  
Fluorescent Probes ◽  
Zinc Complexes ◽  
Diagnostic Tools ◽  
Fluorescent Chemosensors

Recent applications of zinc(ii) complexes as fluorescent probes for nucleic acids are described highlighting their potential as diagnostic tools.

BODIPY-modified uridines as potential fluorescent probes for nucleic acids that are recognized by DNA-polymerases

2008 ◽  
Vol 52 (1) ◽  
pp. 349-350 ◽  
Author(s):  
T. Ehrenschwender ◽  
C. Wanninger-Weiss ◽  
H.-A. Wagenknecht
Keyword(s):  
Nucleic Acids ◽  
Fluorescent Probes ◽  
Dna Polymerases

Studies of monomeric and homodimeric oxazolo[4,5-b]pyridinium cyanine dyes as fluorescent probes for nucleic acids visualization

2006 ◽  
Vol 68 (3) ◽  
pp. 155-165 ◽  
Author(s):  
V.B. Kovalska ◽  
V.P. Tokar ◽  
M.Yu. Losytskyy ◽  
T. Deligeorgiev ◽  
A. Vassilev ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Fluorescent Probes ◽  
Cyanine Dyes
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