THE EFFECTS OF MA-XING-GAN-SHI-TANG ON RESPIRATORY RESISTANCE AND AIRWAY LEUKOCYTE INFILTRATION IN ASTHMATIC GUINEA PIGS

2001 ◽  
Vol 23 (3) ◽  
pp. 445-458 ◽  
Author(s):  
Shung-Te Kao ◽  
Tsung-Jen Yeh ◽  
Chang-Chi Hsieh ◽  
Hung-Bo Shiau ◽  
Feng-Tsgh Yeh ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Leukocyte Infiltration ◽  
Respiratory Resistance

A comparison of the effect of inhaled diuretics on airway reflexes in humans and guinea pigs

1992 ◽  
Vol 72 (2) ◽  
pp. 434-438 ◽  
Author(s):  
J. A. Karlsson ◽  
N. B. Choudry ◽  
C. Zackrisson ◽  
R. W. Fuller
Keyword(s):  
Citric Acid ◽  
Guinea Pig ◽  
Airway Obstruction ◽  
Guinea Pigs ◽  
Airway Resistance ◽  
Loop Diuretic ◽  
Airflow Obstruction ◽  
Respiratory Resistance ◽  
Airway Mucosa ◽  
Maximum Inhibition

The effects of nebulized diuretics on citric acid-induced cough and airway obstruction in guinea pigs and capsaicin-induced cough and increase in airway resistance in humans have been studied. Half-maximum inhibition of cough in the guinea pig was produced by 1.3 mM furosemide and 0.25 mM hydrochlorothiazide. Cough was inhibited by 78 +/- 9% by 3 mM furosemide (P less than 0.05) and 89 +/- 11% by 3 mM hydrochlorothiazide (P less than 0.01). At the same time, airway obstruction was inhibited by 50 +/- 9% (P less than 0.001) and 42 +/- 15% (P less than 0.05), respectively. Nebulized furosemide (3 mM) was without effect on the airway obstruction produced by inhaled histamine or acetylcholine in the guinea pigs. Intravenously administered furosemide (270 nmol/kg) did not affect citric acid-induced responses. In humans, aerosolized furosemide (9 mM) and hydrochlorothiazide (3.4 mM) reduced the percent increase in respiratory resistance from 22.1 +/- 3.7 and 15.6 +/- 3.4 to 10.5 +/- 4.9 and 9.4 +/- 3.3%, respectively (P less than 0.05), but were without effect on cough due to capsaicin. Thus both furosemide and hydrochlorothiazide inhibited airway obstruction in the guinea pig and reduced the capsaicin-induced increase in airway resistance in humans. However, whereas coughing was inhibited in the guinea pig, neither drug affected cough in humans. This difference in the action of the loop diuretic and thiazide, which interact differently with Na(+)-K(+)-Cl-transport within the airway mucosa, on the cough and airflow obstruction in guinea pig and humans supports the view that different sensory limbs are involved in these reflexes.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Effects of Theophylline Compared with Prednisolone on Late Phase Airway Leukocyte Infiltration in Guinea Pigs

1991 ◽  
Vol 94 (1-4) ◽  
pp. 293-294 ◽  
Author(s):  
R.W. Gristwood ◽  
J. Llupiá ◽  
A.G. Fernández ◽  
P. Berga
Keyword(s):  
Guinea Pigs ◽  
Late Phase ◽  
Leukocyte Infiltration

Rapamycin inhibits airway leukocyte infiltration and hyperreactivity in guinea pigs

1993 ◽  
Vol 39 (S1) ◽  
pp. C139-C141 ◽  
Author(s):  
J. N. Francischi ◽  
D. Conroy ◽  
K. Maghni ◽  
P. Sirois
Keyword(s):  
Guinea Pigs ◽  
Leukocyte Infiltration

Effect of San-Ao-Tang on Immediate and Late Airway Response and Leukocyte Infiltration in Asthmatic Guinea Pigs

2000 ◽  
Vol 22 (1) ◽  
pp. 143-162 ◽  
Author(s):  
Shung-Te Kao ◽  
Tsung-Jen Yeh ◽  
Chang-Chi Hsieh ◽  
Feng-Tsgh Yeh ◽  
Jaung-Geng Lin
Keyword(s):  
Guinea Pigs ◽  
Leukocyte Infiltration ◽  
Airway Response

scholarly journals Effects of lecithinized superoxide dismutase (PC-SOD) on respiratory resistance induced by Forssman antiserum in guinea pigs

Ensho ◽  
1992 ◽  
Vol 13 (3) ◽  
pp. 249-254
Author(s):  
Jiro Hoshino ◽  
Akira Ochiai ◽  
Rie Igarashi ◽  
Yukio Ueno ◽  
Toshiaki Nakayama ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Guinea Pigs ◽  
Respiratory Resistance
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