scholarly journals Effects of lecithinized superoxide dismutase (PC-SOD) on respiratory resistance induced by Forssman antiserum in guinea pigs

Ensho ◽  
1992 ◽  
Vol 13 (3) ◽  
pp. 249-254
Author(s):  
Jiro Hoshino ◽  
Akira Ochiai ◽  
Rie Igarashi ◽  
Yukio Ueno ◽  
Toshiaki Nakayama ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Guinea Pigs ◽  
Respiratory Resistance

Response of antioxidant enzymes to intermittent and continuous hyperbaric oxygen

1990 ◽  
Vol 69 (1) ◽  
pp. 328-335 ◽  
Author(s):  
A. L. Harabin ◽  
J. C. Braisted ◽  
E. T. Flynn
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Glutathione Peroxidase ◽  
Oxidative Damage ◽  
Hyperbaric Oxygen ◽  
Enzyme Activities ◽  
Guinea Pigs ◽  
Exposure Duration ◽  
Biochemical Variables ◽  
Time Required

Rats and guinea pigs were exposed to O2 at 2.8 ATA (HBO) delivered either continuously or intermittently (repeated cycles of 10 min of 100% O2 followed by 2.5 min of air). The O2 time required to produce convulsions and death was increased significantly in both species by intermittency. To determine whether changes in brain and lung superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSHPx) correlated with the observed tolerance, enzyme activities were measured after short or long HBO exposures. For each exposure duration, one group received continuous and one intermittent HBO; O2 times were matched. HBO had marked effects on these enzymes: lung SOD increased (guinea pigs 47%, rats 88%) and CAT and GSHPx activities decreased (33%) in brain and lung. No differences were seen in lung GSHPx or brain CAT in rats or brain SOD in either species. In guinea pigs, but less so in rats, the observed changes in activity were usually modulated by intermittency. Increases in hematocrit, organ protein, and lung DNA, which may also reflect ongoing oxidative damage, were also slowed with intermittency in guinea pigs. Intermittency benefited both species by postponing gross symptoms of toxicity, but its modulation of changes in enzyme activities and other biochemical variables was more pronounced in guinea pigs than in rats, suggesting that there are additional mechanisms for tolerance.

A comparison of the effect of inhaled diuretics on airway reflexes in humans and guinea pigs

1992 ◽  
Vol 72 (2) ◽  
pp. 434-438 ◽  
Author(s):  
J. A. Karlsson ◽  
N. B. Choudry ◽  
C. Zackrisson ◽  
R. W. Fuller
Keyword(s):  
Citric Acid ◽  
Guinea Pig ◽  
Airway Obstruction ◽  
Guinea Pigs ◽  
Airway Resistance ◽  
Loop Diuretic ◽  
Airflow Obstruction ◽  
Respiratory Resistance ◽  
Airway Mucosa ◽  
Maximum Inhibition

The effects of nebulized diuretics on citric acid-induced cough and airway obstruction in guinea pigs and capsaicin-induced cough and increase in airway resistance in humans have been studied. Half-maximum inhibition of cough in the guinea pig was produced by 1.3 mM furosemide and 0.25 mM hydrochlorothiazide. Cough was inhibited by 78 +/- 9% by 3 mM furosemide (P less than 0.05) and 89 +/- 11% by 3 mM hydrochlorothiazide (P less than 0.01). At the same time, airway obstruction was inhibited by 50 +/- 9% (P less than 0.001) and 42 +/- 15% (P less than 0.05), respectively. Nebulized furosemide (3 mM) was without effect on the airway obstruction produced by inhaled histamine or acetylcholine in the guinea pigs. Intravenously administered furosemide (270 nmol/kg) did not affect citric acid-induced responses. In humans, aerosolized furosemide (9 mM) and hydrochlorothiazide (3.4 mM) reduced the percent increase in respiratory resistance from 22.1 +/- 3.7 and 15.6 +/- 3.4 to 10.5 +/- 4.9 and 9.4 +/- 3.3%, respectively (P less than 0.05), but were without effect on cough due to capsaicin. Thus both furosemide and hydrochlorothiazide inhibited airway obstruction in the guinea pig and reduced the capsaicin-induced increase in airway resistance in humans. However, whereas coughing was inhibited in the guinea pig, neither drug affected cough in humans. This difference in the action of the loop diuretic and thiazide, which interact differently with Na(+)-K(+)-Cl-transport within the airway mucosa, on the cough and airflow obstruction in guinea pig and humans supports the view that different sensory limbs are involved in these reflexes.(ABSTRACT TRUNCATED AT 250 WORDS)

THE EFFECTS OF MA-XING-GAN-SHI-TANG ON RESPIRATORY RESISTANCE AND AIRWAY LEUKOCYTE INFILTRATION IN ASTHMATIC GUINEA PIGS

2001 ◽  
Vol 23 (3) ◽  
pp. 445-458 ◽  
Author(s):  
Shung-Te Kao ◽  
Tsung-Jen Yeh ◽  
Chang-Chi Hsieh ◽  
Hung-Bo Shiau ◽  
Feng-Tsgh Yeh ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Leukocyte Infiltration ◽  
Respiratory Resistance

Polyethylene Glycol-conjugated Superoxide Dismutase Attenuates Septic Lung Injury in Guinea Pigs

1992 ◽  
Vol 145 (2_pt_1) ◽  
pp. 388-393 ◽  
Author(s):  
Yukio Suzuki ◽  
Toshimori Tanigaki ◽  
Dov Heimer ◽  
Weizheng Wang ◽  
William G. Ross ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Polyethylene Glycol ◽  
Lung Injury ◽  
Guinea Pigs

scholarly journals Condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress

2021 ◽  
Vol 11 (5) ◽  
pp. 319-324
Author(s):  
Yurij Kryvko ◽  
Yurij Soguiko ◽  
Iryna Hot ◽  
Yuliia Antonenko ◽  
Mariana Baida ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Experimental Model ◽  
Experimental Work ◽  
Guinea Pigs ◽  
Immobilization Stress ◽  
Antioxidant Systems ◽  
Conjugated Diene ◽  
Antioxidant Defence

We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs (control), II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd  day of experiment;IV- group of animals on 34th day of experimental model of IS. The results of our experimental work showed a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods (on 1st, 2nd and 34th days) of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin). disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development.

Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic

2005 ◽  
Vol 39 (4) ◽  
pp. 520-531 ◽  
Author(s):  
Emanuela Masini ◽  
Daniele Bani ◽  
Alfredo Vannacci ◽  
Simone Pierpaoli ◽  
Pier Francesco Mannaioni ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Airway Inflammation ◽  
Guinea Pigs
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