scholarly journals Effect of dietary proteins on insulin-like growth factor-1 (IGF-1) messenger ribonucleic acid content in rat liver

1992 ◽  
Vol 67 (2) ◽  
pp. 257-265 ◽  
Author(s):  
Yutaka Miura ◽  
Hisanori Kato ◽  
Tadashi Noguchi
Keyword(s):  
Growth Factor ◽  
Rat Liver ◽  
Soya Bean ◽  
Dietary Proteins ◽  
Insulin Like Growth Factor ◽  
Casein Diet ◽  
Mrna Species ◽  
Mrna Content ◽  
Protein Free Diet

Effects of quantity and quality of dietary proteins on plasma immunoreactive insulin-like growth factor-1 (IGF-1) concentration, and content of IGF-1 mRNA in rat liver were investigated in rats. Plasma immunoreactive IGF-1 concentration in rats given a casein diet was higher than that in rats given a soya-bean-protein or protein-free diet. The IGF-1 mRNA content in liver was estimated by the Northern blot hybridization technique employing 32P-labelled rat IGF-1 complementary DNA (cDNA). At least four molecular species of IGF-1 mRNA of different molecular weight were found in rat liver. The sizes were 0·8–1·2, 2·0, 3·6–4·0 and 7·4 kb. Most of the mRNA species decreased in the livers of rats given a gluten diet (120 g gluten/kg diet) compared with rats given the casein diet. In particular, mRNA of 7·4 kb decreased markedly. When rats were fed on the protein-free diet, mRNA of all species decreased significantly. The estimated IGF-1 mRNA in the livers of rats fed on the gluten or protein-free diet was almost 0·4 of that of the rats given the casein diet. Feeding the soya-bean-protein diet did not result in a marked effect on the hepatic content of mRNA species of IGF-1. The results showed that liver IGF-1 mRNA content is sensitively regulated by quantity and nutritional quality of dietary proteins.

scholarly journals Effect of protein nutrition on the mRNA content of insulin-like growth factor-binding protein-1 in liver and kidney of rats

1993 ◽  
Vol 69 (1) ◽  
pp. 73-82 ◽  
Author(s):  
Asako Takenaka ◽  
Mitsuko Hirosawa ◽  
Masamichi Mori ◽  
Sanae Yamada ◽  
Yutaka Miura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Casein Diet ◽  
Liver Parenchymal ◽  
Factor Binding ◽  
Mrna Content ◽  
Liver And Kidney ◽  
Protein Free Diet ◽  
Parenchymal Cells

Effect of quantity and nutritional quality of dietary proteins on the content of mRNA of insulin-like growth factor-binding protein-1 (IGFBP-1) was studied in rat liver and kidney. IGFBP-1 mRNA content per unit RNA increased in liver and kidney of rats fed on a protein-free diet and in those of fasted rats compared with that in the rats fed on a casein diet. When rats were given a gluten diet for 7 d, IGFBP-1 mRNA content in liver did not change significantly but that in kidney increased considerably compared with that in those organs of the rats fed on the casein diet. Because IGFBP-1 mRNA has been demonstrated both in liver parenchymal and non-parenchymal cells (Takenaka et al. 1991), the effect of the protein-free diet on these two types of cells has been studied. An increase in IGFBP-1 mRNA content under protein deprivation was observed in both liver parenchymal and non-parenchymal cells, suggesting that these two types of cells are regulated in a similar mode as far as IGFBP-1 mRNA content is concerned. The physiological and nutritional significance of the previously stated results on protein anabolism are discussed when considered together with our previous observations on the plasma concentrations of IGF-1 (Takahashi et al. 1990) and IGFBP (Umezawa et al. 1991) and insulin-like growth factor-1 mRNA content in liver (Miura et al. 1991).

scholarly journals Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients

2021 ◽  
Author(s):  
Cody Z. Watling ◽  
Rebecca K. Kelly ◽  
Tammy Y.N. Tong ◽  
Carmen Piernas ◽  
Eleanor L. Watts ◽  
...  
Keyword(s):  
Growth Factor ◽  
Dietary Proteins ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Acromegaly in Routine Clinical Practice in Germany, Austria and Switzerland

2020 ◽  
Author(s):  
Sylvère Störmann ◽  
Jochen Schopohl ◽  
Catharina Bullmann ◽  
Christoph Terkamp ◽  
Mirjam Christ-Crain ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Growth Hormone ◽  
Growth Factor ◽  
Real World ◽  
Insulin Like Growth Factor ◽  
Biochemical Control ◽  
Factor I ◽  
Lanreotide Autogel

Abstract Background Evidence from controlled trials has shown that lanreotide autogel is effective in achieving biochemical and symptom control in patients with acromegaly. However, it is important to better understand the real-world patient population receiving lanreotide autogel treatment. Methods In this non-interventional study the long-term treatment response to lanreotide autogel in adult patients with acromegaly from office-based centers or clinics in Germany, Austria and Switzerland was studied. Assessments included growth hormone and insulin-like growth factor-I levels, symptoms, quality of life, lanreotide plasma levels and tumor somatostatin receptor subtype expression. The primary endpoint was achievement of full biochemical control, defined as growth hormone ≤2.5 µg/L and insulin-like growth factor I normalization at month 12. Results 76 patients were enrolled from 21 sites. 7/51 (13.7%) patients of the efficacy population had full biochemical control at baseline, 15/33 (45.5%) at month 12 and 10/26 (38.5%) at month 24 of treatment. At 12 months of treatment higher rates of biochemical control were observed in the following subgroups: older patients (>53 years [median]), females, treatment-naïve patients, and patients with a time since diagnosis of longer than 1.4 years (median). No clinically relevant differences in acromegaly symptoms or quality of life scores were observed. Median fasting blood glucose and glycated hemoglobin levels remained unchanged throughout the study. No new safety signals were observed. Overall tolerability of treatment with lanreotide autogel was judged by 80.8% of the enrolled patients at month 12 as ‘very good’ or ‘good’. Conclusion Treatment with lanreotide autogel in a real-world setting showed long-term effectiveness and good tolerability in patients with acromegaly.

scholarly journals Heterogeneity of insulin-like growth factor binding proteins between structure and affinity. 2. Forms released by human and rat liver in culture

1987 ◽  
Vol 170 (1-2) ◽  
pp. 133-142 ◽  
Author(s):  
Paul HOSSENLOPP ◽  
Danielle SEURIN ◽  
Berta SEGOVIA ◽  
Ghyslaine PORTOLAN ◽  
Michel BINOUX
Keyword(s):  
Growth Factor ◽  
Rat Liver ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Factor Binding

Nutraceuticals for Promoting Longevity

2020 ◽  
Vol 1 (1) ◽  
pp. 18-32
Author(s):  
Ivan Pavlović ◽  
Soliman Khateb ◽  
Irina Milisav ◽  
Jamal Mahajna
Keyword(s):  
Growth Factor ◽  
Caloric Restriction ◽  
Literature Search ◽  
The Elderly ◽  
Insulin Like Growth Factor ◽  
Receptor Signaling ◽  
Mental Performance ◽  
Environmental Manipulation ◽  
Multiple Chronic Diseases

Objective: To summarize the main findings on nutraceuticals that slow aging processes by delaying and even preventing the development of multiple chronic diseases and improve productivity and quality of life in the elderly. Methods: Literature search of the relevant papers known to the authors was conducted. Results: The most robust environmental manipulation for extending lifespan is caloric restriction without malnutrition. Some nutraceuticals can mimic caloric restriction effects. This review will focus on the nutraceuticals that impact insulin-like growth factor 1 receptor signaling and sirtuin activity in mediating longevity and healthspan. Conclusion: Aging is considered to be synonymous with the appearance of major diseases and an overall decline in physical and mental performance. Caloric restriction is well established as a strategy to extend lifespan without malnutrition. A variety of nutraceuticals were reported to mimic the effect of caloric restriction by modulating the activity of insulin-like growth factor 1 receptor signaling and sirtuin activity and consequently promote longevity and healthspan.

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