The early anaemia of the premature infant: is there a place for vitamin E supplementation?

1986 ◽  
Vol 56 (1) ◽  
pp. 105-114 ◽  
Author(s):  
S. P. Conway ◽  
I Rawson ◽  
P. R. F. Dear ◽  
S. E. Shires ◽  
J. Kelleher
Keyword(s):  
Vitamin E ◽  
Premature Infant ◽  
Premature Baby ◽  
Oral Feeding ◽  
Plasma Vitamin ◽  
Double Blind ◽  
Plasma Vitamin E ◽  
Sufficient Vitamin ◽  
Vitamin E Supplementation

1. The efficacy of oral vitamin E supplementation in preventing the early anaemia of the premature infant was assessed in a 10-week double-blind trial. Forty-two babies received either a placebo or 5 or 15 mg supplementary vitamin E/d with oral feeding. No infant received less than the recommended vitamin E:polyunsaturated fatty acid (E:PUFA) value of 0.6. No iron supplement was given.2. Weekly full blood counts were taken, and plasma vitamin E assay and in vitro haemolysis tests performed on blood sampled on day 1, and also at 6 and 10 weeks of age. All blood withdrawn and transfused and all feeds were documented.3. Thirty-six (86%) of the babies had a plasma vitamin E level at birth below the accepted adult norm, i.e. < 5200 μg/l. At 6 weeks of age thirty-three (79%) and at 10 weeks thirty-five (83%) of the babies had levels within the normal adult range. No baby showed either clinical or haematological evidence of a vitamin E deficiency state during the trial.4. It is concluded that in the absence of Fe supplementation and observing the minimum recommended E:PUFA value, contemporary feeding practices allow for the absorption of sufficient vitamin E by the premature baby to prevent the development of an early haemolytic anaemia.5. No significant relation was found between plasma vitamin E levels and the degree of peroxide haemolysis.

Retrolental Fibroplasia and Vitamin E in the Preterm Infant—Comparison of Oral Versus Intramuscular:Oral Administration

PEDIATRICS ◽  
1984 ◽  
Vol 73 (2) ◽  
pp. 238-249
Author(s):  
Helen M. Hittner ◽  
Michael E. Speer ◽  
Arnold J. Rudolph ◽  
Cindy Blifeld ◽  
Prabhujeet Chadda ◽  
...  
Keyword(s):  
Vitamin E ◽  
Very Low Birth Weight ◽  
Plasma Vitamin ◽  
Oral Vitamin ◽  
Low Birth Weight Infants ◽  
Retrolental Fibroplasia ◽  
Intramuscular Injections ◽  
Significant Difference ◽  
Plasma Vitamin E ◽  
Vitamin E Supplementation

To evaluate the efficacy of four early intramuscular injections of vitamin E given in addition to continuous minimal oral vitamin E supplementation, 168 very low-birth-weight infants (≤1,500 g) have enrolled in a randomized, double-masked, clinical study. All infants received vitamin E orally, 100 mg/kg/d. In addition, on days 1, 2, 4, and 6, seventy-nine infants received vitamin E intramuscularly, 15, 10, 10, and 10 mg/kg, respectively. On the same days, 89 control infants received placebo intramuscular injections. Multivariate analysis of the 135 infants who survived ≥10 weeks showed no significant difference in the development of severe retrolental fibroplasia between these two supplementation schedules (P = .86). Plasma vitamin E levels never exceeded a mean of 3.3 mg/100 mL, and no toxicity was observed. Ultrastructural analyses of seven pairs of whole eye donations from infants receiving IM vitamin E demonstrated identical kinetics of gap junction formation between adjacent spindle cells as compared with 13 pairs of whole eye donations from control infants (P &gt; .3). Therefore, oral vitamin E supplementation affords retinal protection against the development of severe retrolental fibroplasia when initiated on the first day of life and maintained continuously until retinal vascularization is complete.

scholarly journals Plasma Vitamin E and the Risk of First Stroke in Hypertensive Patients: A Nested Case-Control Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Yun Song ◽  
Jingyi Li ◽  
Lishun Liu ◽  
Richard Xu ◽  
Ziyi Zhou ◽  
...  
Keyword(s):  
Vitamin E ◽  
Case Control Study ◽  
Case Control ◽  
Plasma Vitamin ◽  
Double Blind ◽  
Clinical Trial Registration ◽  
Hypertensive Patients ◽  
Plasma Vitamin E ◽  
Nested Case Control ◽  
Control Study

Background: The association between plasma vitamin E levels and first stroke risk in men and women remains unclear.Objective: We aimed to examine the prospective association between plasma vitamin E and first stroke, and evaluate the effect modifiers for the association, among hypertensive patients.Design: The study sample was drawn from the China Stroke Primary Prevention Trial (CSPPT), which randomized a total of 20,702 hypertensive patients to a double-blind, daily treatment with either 10 mg enalapril and 0.8 mg folic acid or 10 mg enalapril alone. This nested case-control study, including 618 first stroke cases and 618 controls matched for age, sex, treatment group, and study site, was conducted after the completion of the CSPPT.Results: The median follow-up duration was 4.5 years. Among men, a significantly higher risk of first stroke (adjusted OR, 1.67; 95%CI: 1.01, 2.77) was found for those with plasma vitamin E ≥7.1 μg/mL (≥quartile 1) compared with those with plasma vitamin E &lt; 7.1 μg/mL. Subgroup analyses further showed that the association between vitamin E (≥7.1 vs. &lt;7.1 μg/mL) and first stroke in men was significantly stronger in non-drinkers (adjusted OR, 2.64; 95%CI: 1.41, 4.96), compared to current drinkers (adjusted OR, 0.84; 95% CI: 0.43, 1.66, P-interaction = 0.008). However, there was no significant association between plasma vitamin E and first stroke in women (P-interaction between sex and plasma vitamin E = 0.048).Conclusions: Among Chinese hypertensive patients, there was a statistically significant positive association between baseline plasma vitamin E and the risk of first stroke in men, but not in women.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT00794885, Identifier: NCT00794885.

scholarly journals Vitamin E Supplementation and Markers of Oxidative Stress in Indian Acute Myocardial Infarction Patients

2013 ◽  
Vol 5 (2) ◽  
pp. 46-53 ◽  
Author(s):  
Ijen Bhattacharya ◽  
Rahul Saxena ◽  
Raj Saxena ◽  
Alok Milton Lal
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Uric Acid ◽  
Vitamin E ◽  
Vitamin C ◽  
Plasma Vitamin ◽  
Blood Samples ◽  
Markers Of Oxidative Stress ◽  
Vitamin E Supplementation

Background: Reactive oxygen species have been identified as mediators of cell injury in a variety of cardiovascular complications including Myocardial Infarction (MI). It is conceivable that vitamin E supplementation can be used therapeutically due to its role in ameliorating antioxidant status and free radicals scavenging activity. Aim: Therefore, the present study was undertaken to assess the markers of oxidative stress i.e. erythrocyte glutathione peroxidase (GSHPx) & malondialdehyde (MDA); plasma vitamin C, E, A and uric acid level in the blood samples of MI patients and to investigate the effect of in-vitro vitamin E supplementation in ameliorating the levels of these antioxidants in the blood sample of MI patients. Material & Method: 60 MI subjects (age group 30-60 years) were taken for the study and 60 healthy individuals served as controls. In-vitro vitamin E supplementation in the blood samples of MI subjects were performed and above mentioned parameters were estimated by using standard methods. Data was compared statistically by using student t-test. Result: Vitamin E supplementation brought about an improved antioxidants status with significantly raised vitamin C, E, A and GSHPx levels (p<0.05, p<0.001), and simultaneously depleted level of erythrocyte MDA (p<0.001) in blood samples of MI subjects. However, plasma uric acid levels remain unaltered (p<0.1). Conclusion: These findings further support the preventive and cardio protective role of vitamin E supplementation in reducing oxidative stress levels in the blood samples of MI patients. DOI: http://dx.doi.org/10.3126/ajms.v5i2.8430 Asian Journal of Medical Science, Volume-5(2) 2014: 46-53

scholarly journals Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1228
Author(s):  
Katalin Koczok ◽  
László Horváth ◽  
Zeljka Korade ◽  
Zoltán András Mezei ◽  
Gabriella P. Szabó ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Vitamin E ◽  
Vitamin A ◽  
Dietary Cholesterol ◽  
Response To Therapy ◽  
Plasma Vitamin ◽  
Clinical Effects ◽  
Opitz Syndrome ◽  
Plasma Vitamin E ◽  
Vitamin E Supplementation

Smith-Lemli-Opitz syndrome (SLOS) is a severe monogenic disorder resulting in low cholesterol and high 7-dehydrocholesterol (7-DHC) levels. 7-DHC-derived oxysterols likely contribute to disease pathophysiology, and thus antioxidant treatment might be beneficial because of high oxidative stress. In a three-year prospective study, we investigated the effects of vitamin E supplementation in six SLOS patients already receiving dietary cholesterol treatment. Plasma vitamin A and E concentrations were determined by the high-performance liquid chromatography (HPLC) method. At baseline, plasma 7-DHC, 8-dehydrocholesterol (8-DHC) and cholesterol levels were determined by liquid chromatography–tandem mass spectrometry (LC-MS/MS) method. The clinical effect of the supplementation was assessed by performing structured parental interviews. At baseline, patients were characterized by low or low–normal plasma vitamin E concentrations (7.19–15.68 μmol/L), while vitamin A concentrations were found to be normal or high (1.26–2.68 μmol/L). Vitamin E supplementation resulted in correction or significant elevation of plasma vitamin E concentration in all patients. We observed reduced aggression, self-injury, irritability, hyperactivity, attention deficit, repetitive behavior, sleep disturbance, skin photosensitivity and/or eczema in 3/6 patients, with notable individual variability. Clinical response to therapy was associated with a low baseline 7-DHC + 8-DHC/cholesterol ratio (0.2–0.4). We suggest that determination of vitamin E status is important in SLOS patients. Supplementation of vitamin E should be considered and might be beneficial.

Effect of feeding T-2 toxin contaminated feed on the utilisation of vitamin E in chickens

2007 ◽  
Vol 55 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Maria Weber ◽  
Sz. Stiller ◽  
K. Balogh ◽  
L. Wágner ◽  
Márta Erdélyi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Blood Plasma ◽  
Broiler Chickens ◽  
High Dose ◽  
Plasma Vitamin ◽  
Moderate Increase ◽  
Plasma Vitamin E ◽  
Effect Of Feeding ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

The purpose of the present study was to investigate the effect of experimental T-2 toxin load (2.35 mg/kg of feed) and vitamin E supply in the drinking water (10.5 mg/bird/day) on vitamin E levels of the blood plasma and liver in broiler chickens in a 14-day experiment. It was found that T-2 toxin load did not influence vitamin E content of the blood plasma except at day 3 after the toxin load when a moderate increase was detected in plasma vitamin E. No significant changes were found in vitamin E content of the liver. The simultaneous use of high-dose vitamin E supplementation and T-2 toxin load caused a significantly higher plasma vitamin E content but the changes were less expressed in the group subjected to T-2 toxin load. Vitamin E supply also resulted in a marked and significant increase in vitamin E concentrations of the liver on days 3 and 7 even in the T-2 loaded group, but this concentration significantly decreased thereafter. The results show that T-2 contamination of the diet has an adverse effect on the utilisation of vitamin E in broiler chickens.

Effect of forage type and supplemental dietary vitamin E on milk oxidative stability

1991 ◽  
Vol 71 (4) ◽  
pp. 1181-1186 ◽  
Author(s):  
J. W. G. Nicholson ◽  
Anne-Marie St-Laurent
Keyword(s):  
Vitamin E ◽  
Oxidative Stability ◽  
Corn Silage ◽  
Dietary Vitamin ◽  
Plasma Vitamin ◽  
Forage Type ◽  
Alfalfa Silage ◽  
Plasma Vitamin E ◽  
Spontaneous Oxidation ◽  
Vitamin E Supplementation

Twelve Holstein cows in each of two replicates were used to determine the effect of forage type and vitamin E supplementation on the oxidative stability of milk. Alfalfa or corn silage was fed ad libitum as the sole roughage, with a concentrate to milk ratio of 1:2.5. Half the cows on each forage were fed 7000 IU d−1 of dL-α-tocopherol acetate top-dressed on the concentrate in two feedings per day over a 4-wk period. Cows consuming the alfalfa silage had higher (P < 0.05) plasma vitamin E content, but there were no differences in milk vitamin E or flavor due to forage type. Supplementing the diets with vitamin E resulted in higher (P < 0.01) vitamin E content of plasma and milk and improved milk oxidative stability. There was an interaction (P = 0.03) between forage type and vitamin E supplementation for oxidative flavor score in week 2. Supplementing the corn silage diet with 7000 IU d−1 of vitamin E resulted in almost complete elimination of oxidized flavor in milk within 1 wk of starting supplementation. However, supplementing the alfalfa silage diet had no effect on flavor over the first 3 wk of feeding. It is apparent that the vitamin E content of milk is not the sole determinant of its oxidative stability. Key words: Spontaneous oxidation, flavor, milk, vitamin E, alfalfa, corn silage, cow

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation

2006 ◽  
Vol 40 (4) ◽  
pp. 689-697 ◽  
Author(s):  
Richard S. Bruno ◽  
Scott W. Leonard ◽  
Jeffery Atkinson ◽  
Thomas J. Montine ◽  
Rajasekhar Ramakrishnan ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Plasma Vitamin ◽  
Vitamin C Supplementation ◽  
Plasma Vitamin E

scholarly journals Effect of vitamin E intake from food and supplement sources on plasma α- and γ-tocopherol concentrations in a healthy Irish adult population

2014 ◽  
Vol 112 (9) ◽  
pp. 1575-1585 ◽  
Author(s):  
Yang Zhao ◽  
Frank J. Monahan ◽  
Breige A. McNulty ◽  
Mike J. Gibney ◽  
Eileen R. Gibney
Keyword(s):  
Vitamin E ◽  
Adult Population ◽  
Plasma Concentrations ◽  
Fats And Oils ◽  
Food Sources ◽  
Dietary Vitamin ◽  
Plasma Vitamin ◽  
Institute Of Medicine ◽  
Nutrition Survey ◽  
Plasma Vitamin E

Vitamin E is believed to play a preventive role in diseases associated with oxidative stress. The aims of the present study were to quantify vitamin E intake levels and plasma concentrations and to assess dietary vitamin E adequacy in Irish adults. Intake data from the National Adult Nutrition Survey were used; plasma samples were obtained from a representative cohort of survey participants. Plasma α- and γ-tocopherol concentrations were measured by HPLC. The main sources of vitamin E in the diet were ‘butter, spreadable fats and oils’ and ‘vegetables and vegetable dishes’. When vitamin E intake from supplements was taken into account, supplements were found to be the main contributor, making a contribution of 29·2 % to vitamin E intake in the total population. Supplement consumers had significantly higher plasma α-tocopherol concentrations and lower plasma γ-tocopherol concentrations when compared with non-consumers. Consumers of ‘vitamin E’ supplements had significantly higher vitamin E intake levels and plasma α-tocopherol concentrations compared with consumers of other types of supplements, such as multivitamin and fish oil. Comparison with the Institute of Medicine Estimated Average Requirement of 12 mg/d indicated that when vitamin E intake from food and supplement sources was taken into account, 100 % of the study participants achieved the recommended intake levels. When vitamin E intake from food sources was taken into account, only 68·4 % of the females were found to achieve the recommended intake levels compared with 99·2 % of the males. The results of the present study show that dietary vitamin E intake has a significant effect on plasma α- and γ-tocopherol concentrations. Furthermore, they show that the consumption of supplements is a major contributor to overall intake and has a significant effect on plasma vitamin E concentrations in the Irish population.

Feeding concentrate pellets enriched by natural vitamin E keeps the plasma vitamin E above the critical level in calves post-weaning

2021 ◽  
pp. 104672
Author(s):  
Saman Lashkari ◽  
Søren K. Jensen ◽  
Christina B. Hansen ◽  
Kenneth Krogh ◽  
Per Theilgaard ◽  
...  
Keyword(s):  
Vitamin E ◽  
Critical Level ◽  
Plasma Vitamin ◽  
Natural Vitamin ◽  
Plasma Vitamin E
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