scholarly journals Effect of diet on the metabolism of labelled tocopherol in sheep

1977 ◽  
Vol 37 (2) ◽  
pp. 215-225 ◽  
Author(s):  
M. Hidiroglou
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Blood Plasma ◽  
Tissue Distribution ◽  
Single Oral Dose ◽  
Lipid Extract ◽  
Tissue Uptake ◽  
Maize Silage ◽  
Grass Silage

1. Eighteen crossbred wethers were allotted at random (six per treatment) to each of the following diets: (1) maize-silage; (2) grass-silage; and (3) chopped hay. After 6 months a single oral dose of D-α-[5-Me-3H]tocopherol was given to each sheep on these three treatments.2. Blood plasma, rumen liquor and urine radioactivity were measured for 4 d and, at the end of this period, the animals were killed and tissue distribution of3H was determined.3. Maize-silage generally contained less α-tocopherol than grass-silage or hay. Tissue uptake of3H was greater on maize-silage than other diets.4. In muscle, spleen and liver, tocopherol concentrations were lower in the maize-silage than the grass-silage fed animals.5. A tendency to higher uptake of radioactivity was recorded at all times in the plasma and its lipid extract of sheep fed on maize-silage than those fed on grass-silage or hay.6. Urine clearance of radioactivity tended to be higher in animals fed on the maize-silage than those fed on grass-silage or hay. This difference of magnitude in urinary excretion was probably related to the rate of metabolism of the ingested radiotocopherol.

Human Metabolism and Urinary Excretion Kinetics of Nonylphenol in Three Volunteers after a Single Oral Dose

2021 ◽  
Author(s):  
Benedikt Ringbeck ◽  
Vladimir N. Belov ◽  
Christoph Schmidtkunz ◽  
Katja Küpper ◽  
Wolfgang Gries ◽  
...  
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Single Oral Dose ◽  
Human Metabolism ◽  
Excretion Kinetics ◽  
Kinetics Of

scholarly journals Vitamin B12absorption in the neonatal piglet

1985 ◽  
Vol 54 (1) ◽  
pp. 245-255 ◽  
Author(s):  
N. M. F. Trugo ◽  
J. E. Ford ◽  
B. F. Sansom
Keyword(s):  
Oral Dose ◽  
Blood Plasma ◽  
Single Oral Dose ◽  
The Body ◽  
Whole Body ◽  
Vitamin B ◽  
Weaned Piglets ◽  
High Concentration ◽  
Neonatal Piglets ◽  
Natural Analogues

1. The vitamin B12in sows' milk is strongly attached to a specific ‘binder’ protein, which is present in excess. The influence of this ‘binder’ on the uptake and retention of cyanocobalamin and two natural analogues(cobinamide and Co-α-[2-methyladenyl]cobamide) was investigated with neonatal piglets.2. Retention of a single oral dose of cyano[58Co]cobalamin given before 7 d of age was consistently higher with suckled than with early-weaned piglets, as determined by measurement of whole-body radioactivity.3. Efficiency of retention declined with age, more rapidly in early-weaned than in suckled animals; when the dose was given at 14 d approximately 30% was retained by both groups.4. Distribution of the retained cyano[58Co]cobalamin within the body of the piglets was the same in both groups; about half was present in the liver.5. Foraging piglets may ingest adventitious vitamin B12and its analogues, which are present in the sow's faeces and in contaminated litter. The influence of the vitamin B12-binder in sows' milk on the uptake and retention of two non-cobalamin analogues, and the effects of the analogues on the uptake and retention of vitamin B12from 2 to 14 d after parturition, were investigated with early-weaned piglets.6. The analogues were detected in the liver but not in the body organs. They were also present in blood plasma, urine and bile, in high concentration relative to that of vitamin B12. The content of analogues in the liver was very small in relation to the amounts ingested, and much less than that of vitamin B12. There was no indication that the vitamin B12-binder in sows' milk influenced uptake and retention of the analogues, or that ingestion of analogues affected the content of vitamin B12in the body organs and fluids examined.

scholarly journals Metabolic studies of [75Se]selenocystine and [75Se]selenomethionine in the rat

1975 ◽  
Vol 34 (3) ◽  
pp. 501-509 ◽  
Author(s):  
Christine D. Thomson ◽  
Bridget A. Robinson ◽  
R. D. H. Stewart ◽  
Marion F. Robinson
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Tissue Distribution ◽  
Similar Rate ◽  
Whole Body ◽  
Rabbit Kidney ◽  
Body Retention ◽  
Metabolic Pool

1. The long-term fate in rats of an oral dose of [75Se]selenocystine was compared with that of an oral dose of [75Se]selenomethionine.2. Urinary and faecal radioactivities were measured during the 1st week and whole-body radioactivity was determined for 10 weeks. Rats were killed at weekly intervals for 4 weeks and at weeks 6 and 10 for analysis of tissue distribution of 75Se.3. Intestinal absorption of [75Se]selenocystine was 81% of the administered dose; that of [75Se]selenomethionine was 86%. Urinary excretion of absorbed [75Se]selenocystine was 13.9% and that of [75Se]selenomethionine was 5.8%, in the 1st week.4. Whole-body retention of 75Se was greater for [75Se]selenomethionine than for [75Se]-selenocystine but after the 1st week it decreased at a similar rate in both groups. Tissue distribution of retained 75Se was also similar in both groups.5. The initial utilization of [75Se]selenocystine was different from that of [75Se]selenomethionine. However, after the 1st week 75Se from both sources appeared to be metabolized similarly, suggesting that dietary Se of both forms is ultimately incorporated into the same metabolic pool.6. When these findings were compared with those of earlier studies with [75Se]selenite and 75Se incorporated in vivo into rabbit kidney (RK-75Se) (Thomson, Stewart & Robinson, 1975) the metabolism of [75Se]selenocystine resembled that of [75Se]selenite and RK-75Se, rather than that of [75Se]selenomethionine.

scholarly journals Effect of Dietary Cadmium on Tissue Distribution of 109Cadmium Following a Single Oral Dose in Young Goats

1969 ◽  
Vol 52 (12) ◽  
pp. 2029-2035 ◽  
Author(s):  
W.J. Miller ◽  
D.M. Balckmon ◽  
R.P. Gentry ◽  
F.M. Pate
Keyword(s):  
Oral Dose ◽  
Tissue Distribution ◽  
Single Oral Dose ◽  
Dietary Cadmium
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