Model representation of salicylate pharmacokinetics using unbound plasma salicylate concentrations and metabolite urinary excretion rates following a single oral dose

1991 ◽  
Vol 19 (5) ◽  
pp. 575-595 ◽  
Author(s):  
J. Shen ◽  
S. Wanwimolrak ◽  
R. D. Purves ◽  
E. G. McQueen ◽  
M. S. Roberts
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Single Oral Dose ◽  
Model Representation ◽  
Excretion Rates

Human Metabolism and Urinary Excretion Kinetics of Nonylphenol in Three Volunteers after a Single Oral Dose

2021 ◽  
Author(s):  
Benedikt Ringbeck ◽  
Vladimir N. Belov ◽  
Christoph Schmidtkunz ◽  
Katja Küpper ◽  
Wolfgang Gries ◽  
...  
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Single Oral Dose ◽  
Human Metabolism ◽  
Excretion Kinetics ◽  
Kinetics Of

scholarly journals Time Pattern of Vitamin B12Co60 Urinary Excretion in Man After Oral Administration and Parenteral "Flushing"

Blood ◽  
1956 ◽  
Vol 11 (4) ◽  
pp. 352-356 ◽  
Author(s):  
WILLIAM R. BEST ◽  
WENDELL A. LANDMANN ◽  
LOUIS R. LIMARZI
Keyword(s):  
Oral Dose ◽  
Oral Administration ◽  
Urinary Excretion ◽  
Pernicious Anemia ◽  
Intrinsic Factor ◽  
Time Pattern ◽  
Number Of Patients ◽  
Excretion Rates ◽  
The Individual ◽  
Factor Concentrate

Abstract Serial urine collections in a number of patients with pernicious anemia given 2 µg B12Co60 orally followed in two hours by 1000 µg nonradioactive vitamin B12 showed little urinary radioactivity at any time. When these tests were repeated together with a potent oral dose of intrinsic factor concentrate, there was little activity during the first four hours. Peak excretion rates occurred most commonly between 6 and 12 hours after ingestion of radioactive B12, sometimes even later. The time of peak excretion was fairly characteristic for the individual. Secondary peaks occasionally occurred, and only slight radioactivity usually remained after 24 hours. It is postulated that the delayed peak is related to the time it takes for B12 to be transported in the intestine to the point of absorption or to the duration of the intracellular metabolic processes of absorption. For most purposes the use of fractional urinary collections is not necessary.

scholarly journals Effect of diet on the metabolism of labelled tocopherol in sheep

1977 ◽  
Vol 37 (2) ◽  
pp. 215-225 ◽  
Author(s):  
M. Hidiroglou
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Blood Plasma ◽  
Tissue Distribution ◽  
Single Oral Dose ◽  
Lipid Extract ◽  
Tissue Uptake ◽  
Maize Silage ◽  
Grass Silage

1. Eighteen crossbred wethers were allotted at random (six per treatment) to each of the following diets: (1) maize-silage; (2) grass-silage; and (3) chopped hay. After 6 months a single oral dose of D-α-[5-Me-3H]tocopherol was given to each sheep on these three treatments.2. Blood plasma, rumen liquor and urine radioactivity were measured for 4 d and, at the end of this period, the animals were killed and tissue distribution of3H was determined.3. Maize-silage generally contained less α-tocopherol than grass-silage or hay. Tissue uptake of3H was greater on maize-silage than other diets.4. In muscle, spleen and liver, tocopherol concentrations were lower in the maize-silage than the grass-silage fed animals.5. A tendency to higher uptake of radioactivity was recorded at all times in the plasma and its lipid extract of sheep fed on maize-silage than those fed on grass-silage or hay.6. Urine clearance of radioactivity tended to be higher in animals fed on the maize-silage than those fed on grass-silage or hay. This difference of magnitude in urinary excretion was probably related to the rate of metabolism of the ingested radiotocopherol.

Metabolism and urinary excretion kinetics of di(2-ethylhexyl) adipate (DEHA) in four human volunteers after a single oral dose

2020 ◽  
Vol 321 ◽  
pp. 95-102 ◽  
Author(s):  
Alexandra Nehring ◽  
Daniel Bury ◽  
Benedikt Ringbeck ◽  
Hans-Willi Kling ◽  
Rainer Otter ◽  
...  
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Single Oral Dose ◽  
Excretion Kinetics ◽  
Human Volunteers ◽  
Kinetics Of
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