scholarly journals The absorption of iron, with or without supplements of single amino acids and of ascorbic acid, in healthy and Fe-deficient children

1975 ◽  
Vol 33 (3) ◽  
pp. 351-355 ◽  
Author(s):  
M. F. S. El-Hawary ◽  
F. A. El-Shobaki ◽  
T. Kholeif ◽  
R. Sakr ◽  
M. El-Bassoussy

1. Studies were done on the effect of ascorbic acid and five amino acids (histidine, cystine, cysteine, valine and glutamic acid) on intestinal iron absorption in a group of ninety Egyptian infants and young children, of which fifty-seven were healthy controls and thirty-three were suffering from Fe-deficiency anaemia.2. Supplements tested promoted Fe absorption in healthy controls in the following order: valine > histidine > ascorbic acid. Cysteine, glutamic acid and cystine were found to have no significant effect.3. Supplementation with valine, ascorbic acid and histidine also increased intestinal Fe absorption in anaemic subjects, but to a lesser extent than in controls.4. Supplementation of haematinic therapy with these compounds is recommended. Their use is also suggested to improve the availability of the Fe content of everyday diets.

1975 ◽  
Vol 14 (01) ◽  
pp. 74-80
Author(s):  
M. M. Gupta ◽  
R. Manchanda ◽  
L. Bhattacharyya ◽  
M. Bhargva ◽  
S. Kumar ◽  
...  

SummaryA preliminary study of iron absorption by whole body counting was carried on a group of 16 women. The cases included 8 patients suffering from iron deficiency anaemia and various infections as well as 8 healthy controls. High iron absorption is associated with iron dificiency, these changes being more marked in iron deficient controls than in those with infection or malignancy. In iron deficient controls results of whole body counting correlate very well with other haematological investigations.


1978 ◽  
Vol 17 (1) ◽  
pp. 19-25 ◽  
Author(s):  
F. A. El-Shobaki ◽  
A. Ibrahim ◽  
M. F. S. El-Hawary ◽  
R. Sakr ◽  
A. Said

2018 ◽  
Vol 33 (2) ◽  
pp. 29
Author(s):  
Farid Khan ◽  
Afroza Khanam

Voltammetric technique was used to study the binary and ternary complexes of cadmium with L-amino acids and vitamin-C (L-ascorbic acid) at pH =7.30 ± 0.01, μ = 1.0M KNO3 at 25ºC and 35ºC. Cd (II) formed 1:1:1, 1:1:2 and 1:2:1 complexes with L-lysine, L-ornithine, L-threonine, L-serine, L-phenylglycine, L-phenylalanine, L-glutamic acid and L-aspartic acid used as primary ligands and L-ascorbic acid used as secondary ligand. The trend of stability constant of complexes was Llysine < L-ornithine < L-threonine < L-serine < L-phenylglycine < L-phenylalanine < L-glutamic acid < L-aspartic acid which can be explained on the basis of size, basicity and steric hindrance of ligands. The values of stability constant (log β) varied from 2.23 to11.33 confirm that these drugs i.e. L-aminoacids or in combination with L-ascorbic acid or their complexes could be used against Cd (II) toxicity. The study has been carried out at 35ºC also to determine the thermodynamic parameters such asenthalpy change (ΔH), Free energy change (ΔG) and entropy change (ΔS) respectively.


2021 ◽  
Vol 1 (2) ◽  
pp. 210-214
Author(s):  
Shahrazad Modarres ◽  
Shahab Modarres ◽  
Navideh N. Oskoii

The incidence of rotavirus infection was studied in 704 children less than five years of age who were suffering from acute gastroenteritis, between July 1993 and June 1994 in Teheran. Rotavirus antigen was detected by ELISA in 15. 3% of the stool samples examined, as compared to 1. 1% in a group of healthy controls. The frequency of rotavirus infection was significantly higher among patients under 24 months of age [19. 7%] than among children two years old or more [5. 1%]. Breast-feeding had a protective action against rotavirus infection and the peak of incidence was in the spring. This study revealed that rotavirus is an important etiological agent of acute gastroenteritis among children in Teheran


1958 ◽  
Vol 196 (1) ◽  
pp. 132-134 ◽  
Author(s):  
Herman Cohen ◽  
Herbert Megel ◽  
William Kleinberg

Using adrenal ascorbic acid depletion as a method of assay, it was observed that highly degraded gelatin enhanced ACTH activity to a greater extent than gelatin when subcutaneously administered. This led to the investigation of effect of other polypeptides and amino acids upon ACTH activity. Casein hydrolysate augmented ACTH activity at least fourfold over that of gelatin. Glutamic acid, lysine and pyrrolidone enhanced ACTH activity to the same degree as casein hydrolysate; whereas versene was as effective as gelatin. Casein hydrolysate was ineffective in augmenting FSH activity. The possible mechanism for the enhancement of ACTH by these various agents is discussed.


2021 ◽  
Vol 57 (No. 2) ◽  
pp. 140-147
Author(s):  
Geoffrey Dixon

Soil-borne pathogens such as Verticillium species, invade into the roots of many herbaceous and woody hosts.  The xylem environment supplies these pathogens with a continuous flow of nitrogen-rich nutrition. Detailed quantitative increases in amino acids in the stems, petioles, leaflets and roots of young tomato plants infected with Verticillium. albo-atrum the causal agent of wilt disease, are described in this paper for the first time. Results focus in particular on the vascular environment prior to the emergence of visual symptoms. Total amino acid concentrations in infected stems and petioles increased substantially at 144 and 216 h after inoculation. This effect was evident in leaflets at 216 h after inoculation. By 216 h most amino acid concentrations were substantially increased in stems, petioles and leaflets of infected plants relative to healthy controls. Earlier at 144 h in stems substantial increases were recorded for aspartic acid, threonine, serine, glutamic acid, glycine and ethanolamine. A similar picture emerged for petioles with the addition of increases in proline but not glycine. Amino acids increasing substantially in infected leaflets at 216 h were aspartic acid, glutamic acid and ethanolamine. In the infected roots there was relatively little difference in amino acid concentrations relative to healthy controls with the particular exceptions of proline and ethanolamine. By 18 days (432h), when visual symptoms were well advanced marked increases in amino acid concentrations were found for threonine, serine, α-alanine, valine, methionine, iso-leucine, leucine, tyrosine, ethanolamine, ornithine, lysine, histidine and arginine.


2015 ◽  
Vol 19 (4) ◽  
pp. 716-722 ◽  
Author(s):  
Patricia C Parkin ◽  
Julie DeGroot ◽  
Jonathon L Maguire ◽  
Catherine S Birken ◽  
Stanley Zlotkin

AbstractObjectivesFe-deficiency anaemia (IDA) occurs in 1–2 % of infants in developed countries, peaks at 1–3 years of age and is associated with later cognitive deficits. The objectives of the present study were to describe the characteristics of young children with severe IDA and examine modifiable risk factors in a developed-country setting.DesignTwo prospective samples: a national surveillance programme sample and a regional longitudinal study sample.SettingCanada, 2009–2011.SubjectsTwo samples of young children recruited from community-based health-care practices: a national sample with severe anaemia (Hb<80 g/l) due to Fe deficiency and a regional sample with non-anaemic Fe sufficiency.ResultsChildren with severe IDA (n201, mean Hb 55·1 g/l) experienced substantial morbidity (including developmental delay, heart failure, cerebral thrombosis) and health-care utilization (including a 42 % hospitalization rate). Compared with children with Fe sufficiency (n597, mean Hb 122·4 g/l), children with severe IDA consumed a larger volume of cow’s milk daily (median 1065 mlv. 500 ml,P<0·001) and were more likely to be using a bottle during the day (78 %v. 43 %, OR=6·0; 95 % CI 4·0, 8·9) and also in bed (60 %v. 21 %, OR=6·5; 95 % CI 4·4, 9·5).ConclusionsSevere IDA is associated with substantial morbidity and may be preventable. Three potentially modifiable feeding practices are associated with IDA: (i) cow’s milk consumption greater than 500 ml/d; (ii) daytime bottle use beyond 12 months of age; and (iii) bottle use in bed. These feeding practices should be highlighted in future recommendations for public health and primary-care practitioners.


1998 ◽  
Vol 29 (01) ◽  
pp. 35-39 ◽  
Author(s):  
C. Cerrits ◽  
S. Kamphuis ◽  
L. Monnens ◽  
J. Trijbels ◽  
C. Schröder ◽  
...  

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