scholarly journals Dual Role of the β2-Adrenergic Receptor C Terminus for the Binding of β-Arrestin and Receptor Internalization

2008 ◽  
Vol 283 (46) ◽  
pp. 31840-31848 ◽  
Author(s):  
Cornelius Krasel ◽  
Ulrike Zabel ◽  
Kristina Lorenz ◽  
Susanne Reiner ◽  
Suleiman Al-Sabah ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Dual Role ◽  
Receptor Internalization ◽  
C Terminus ◽  
Β2 Adrenergic Receptor

scholarly journals Properties of Secretin Receptor Internalization Differ from Those of the β2-Adrenergic Receptor

1999 ◽  
Vol 274 (44) ◽  
pp. 31515-31523 ◽  
Author(s):  
Julia K. L. Walker ◽  
Richard T. Premont ◽  
Larry S. Barak ◽  
Marc G. Caron ◽  
Michael A. Shetzline
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Internalization ◽  
Secretin Receptor ◽  
Β2 Adrenergic Receptor

scholarly journals A dileucine motif in the C terminus of the  2-adrenergic receptor is involved in receptor internalization

1997 ◽  
Vol 94 (23) ◽  
pp. 12285-12290 ◽  
Author(s):  
A. M. Gabilondo ◽  
J. Hegler ◽  
C. Krasel ◽  
V. Boivin-Jahns ◽  
L. Hein ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Internalization ◽  
C Terminus ◽  
Dileucine Motif

scholarly journals Dual role of the adenovirus pVI C terminus as a nuclear localization signal and activator of the viral protease

2004 ◽  
Vol 85 (11) ◽  
pp. 3367-3376 ◽  
Author(s):  
K. S. Honkavuori ◽  
B. D. Pollard ◽  
M. S. Rodriguez ◽  
R. T. Hay ◽  
G. D. Kemp
Keyword(s):  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Human Adenovirus ◽  
Dual Role ◽  
Adenovirus Infection ◽  
Heterologous Proteins ◽  
Viral Protease ◽  
C Terminus ◽  
Localization Signal

Adenain, the protease produced by adenovirus, is regulated by formation of a heterodimer with an 11 aa peptide derived from the C terminus of another adenoviral protein, pVI. Here, the role of the basic motif KRRR, which is conserved in pVI sequences from human adenovirus serotypes, was investigated. It was shown that this motif is less important than the N- or C-terminal regions in the formation of the adenain–peptide heterodimer and in the activity of the subsequent complex. This motif, however, acted as a nuclear localization signal that was capable of targeting heterologous proteins to the nucleus, resulting in a distinctive intranuclear distribution consisting of discrete foci, which is similar to that found for pVI during adenovirus infection.

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