Role of β2 -Adrenergic Receptor Polymorphisms on Body Weight and Body Composition Response to Energy Restriction in Obese Women: Preliminary Results

Obesity ◽  
2011 ◽  
Vol 19 (1) ◽  
pp. 212-215 ◽  
Author(s):  
Jonatan R Ruiz ◽  
Eider Larrarte ◽  
Javier Margareto ◽  
Raquel Ares ◽  
Idoia Labayen
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Adrenergic Receptor ◽  
Energy Restriction ◽  
Obese Women ◽  
Preliminary Results ◽  
Β2 Adrenergic Receptor

scholarly journals Impact of Experimentally Induced Cognitive Dietary Restraint on Eating Behavior Traits, Appetite Sensations, and Markers of Stress during Energy Restriction in Overweight/Obese Women

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Isabelle Morin ◽  
Catherine Bégin ◽  
Julie Maltais-Giguère ◽  
Alexandra Bédard ◽  
André Tchernof ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Eating Behavior ◽  
Perceived Stress ◽  
Negative Impact ◽  
Dietary Restraint ◽  
Premenopausal Women ◽  
Energy Restriction ◽  
Obese Women ◽  
Experimentally Induced

Weight loss has been associated with changes in eating behaviors and appetite sensations that favor a regain in body weight. Since traditional weight loss approaches emphasize the importance of increasing cognitive dietary restraint (CDR) to achieve negative energy imbalance, it is difficult to untangle the respective contributions of energy restriction and increases in CDR on factors that can eventually lead to body weight regain. The present study aimed at comparing the effects of energy restriction alone or in combination with experimentally induced CDR on eating behavior traits, appetite sensations, and markers of stress in overweight and obese women. We hypothesized that the combination of energy restriction and induced CDR would lead to more prevalent food cravings, increased appetite sensations, and higher cortisol concentrations than when energy restriction is not coupled with induced CDR. A total of 60 premenopausal women (mean BMI: 32.0 kg/m2; mean age: 39.4 y) were provided with a low energy density diet corresponding to 85% of their energy needs during a 4-week fully controlled period. At the same time, women were randomized to either a condition inducing an increase in CDR (CDR+ group) or a condition in which CDR was not induced (CRD− group). Eating behavior traits (Three-Factor Eating Questionnaire and Food Craving Questionnaire), appetite sensations (after standardized breakfast), and markers of stress (Perceived Stress Scale; postawakening salivary cortisol) were measured before (T = 0 week) and after (T = 4 weeks) the 4-week energy restriction, as well as 3 months later. There was an increase in CDR in the CDR+ group while no such change was observed in the CDR− group (p=0.0037). No between-group differences were observed for disinhibition, hunger, cravings, appetite sensations, perceived stress, and cortisol concentrations. These results suggest that a slight increase in CDR has no negative impact on factors regulating energy balance in the context of energy restriction.

scholarly journals Dual Role of the β2-Adrenergic Receptor C Terminus for the Binding of β-Arrestin and Receptor Internalization

2008 ◽  
Vol 283 (46) ◽  
pp. 31840-31848 ◽  
Author(s):  
Cornelius Krasel ◽  
Ulrike Zabel ◽  
Kristina Lorenz ◽  
Susanne Reiner ◽  
Suleiman Al-Sabah ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Dual Role ◽  
Receptor Internalization ◽  
C Terminus ◽  
Β2 Adrenergic Receptor

scholarly journals 2544

2017 ◽  
Vol 1 (S1) ◽  
pp. 38-38
Author(s):  
Hayley Billingsley ◽  
Salvatore Carbone ◽  
Justin M. Canada ◽  
Leo Buckley ◽  
Dave L. Dixon ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Composition ◽  
Body Weight ◽  
Saturated Fatty Acids ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
The United States ◽  
Fat Free Mass ◽  
Rank Test

OBJECTIVES/SPECIFIC AIMS: Nonalcoholic steatohepatitis (NASH) is a common cause of chronic liver disease in the United States characterized by fat accumulation, inflammation, and fibrosis. Higher amounts of fat-free mass (FFM) and lower amounts of fat mass (FM) have been associated with better outcomes in several chronic diseases, recently also in NASH. Body composition is highly influenced by diet. However, the role of diet on body composition in patients with NASH is largely unknown. We hypothesized that consumption of polyunsaturated fatty acids (PUFA), healthy fatty acids mainly found in fish, nuts, and some vegetable oils, is associated with improved body composition, specifically greater FFM and lower FM, in NASH patients. METHODS/STUDY POPULATION: In total, 13 patients with histologically confirmed NASH underwent body composition testing via bioelectrical impedance analysis to estimate FFM% (% of body weight), FM% (% of body weight), and FFM/FM ratio. PUFA and saturated fat consumption was determined by standardized 5-pass 24-hour dietary recall. Correlations were computed using the Spearman rank test. RESULTS/ANTICIPATED RESULTS: Median body mass index (BMI) was 35.7 kg/m2 (32.8–42.7), median age of the sample was 50 years (46.3–57.3), and 73% were female. Median percent of calories from polyunsaturated fat was 6.8% (5.4–9.6). Percent of calories from PUFA was positively and significantly associated with greater FFM% (R=0.56, p=0.049), lower FM% (R=−0.59, p=0.035), and greater FFM/FM ratio (R=0.58, p=0.037). Additionally, a higher PUFA to saturated fatty acids ratio was also significantly correlated with greater FFM% (R=0.58, p=0.039), lower FM% (R=−0.64, p=0.020), and greater FFM/FM ratio (R=0.57, p=0.043). DISCUSSION/SIGNIFICANCE OF IMPACT: In patients with NASH, the consumption of PUFA is associated with higher FFM and lower FM, which suggests a protective role of these nutrients on body composition. A larger study on patients with NASH is warranted to confirm our findings on PUFA consumption and body composition, as well as to determine whether these effects will improve clinical outcomes.

Multicomponent Training Changes Blood Pressure and Redox Status in Older Women: Influence of β2 Adrenergic Receptor Haplotypes

2020 ◽  
Vol 28 (2) ◽  
pp. 242-249
Author(s):  
Thiago Correa Porto Gonçalves ◽  
Atila Alexandre Trapé ◽  
Jhennyfer Aline Lima Rodrigues ◽  
Simone Sakagute Tavares ◽  
Carlos Roberto Bueno Junior
Keyword(s):  
Blood Pressure ◽  
Body Composition ◽  
Older Women ◽  
Aerobic Capacity ◽  
Adrenergic Receptor ◽  
Exercise Program ◽  
Redox Status ◽  
Genetic Profile ◽  
Before And After ◽  
Β2 Adrenergic Receptor

The β2 adrenergic receptor (β2-AR) plays an important role in vascular smooth muscle. However, the interaction between Arg16Gly and Gln27Glu β2-AR polymorphisms, and exercise training has not yet been established. This study evaluated the influence of these β2-AR polymorphisms on body composition, aerobic capacity, blood pressure, lipid profile, nitric oxide, and redox status at baseline and in response to an exercise program in women aged 50–79 years. Genotype and haplotypes were analyzed in association with the previously mentioned variables before and after the multicomponent training (12 weeks, 2 sessions/week, 90 min/session, and exercise intensity between 13 and 15 on the Borg scale). Individuals who carry β2-AR Arg16Arg/Gln27Gln genotypes presented more improvements in blood pressure, body composition, aerobic capacity, and redox status in response to a multicomponent training program compared with individuals who do not carry this haplotype. In some years, the genetic profile may be used to predict which exercise program can induce more health benefits for each person.

scholarly journals Longitudinal changes in body composition in older men and women: role of body weight change and physical activity

2002 ◽  
Vol 76 (2) ◽  
pp. 473-481 ◽  
Author(s):  
Virginia A Hughes ◽  
Walter R Frontera ◽  
Ronenn Roubenoff ◽  
William J Evans ◽  
Maria A Fiatarone Singh
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Body Weight ◽  
Weight Change ◽  
Older Men ◽  
Body Weight Change ◽  
Men And Women ◽  
Longitudinal Changes ◽  
Older Men And Women

scholarly journals Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

2009 ◽  
Vol 22 (4) ◽  
pp. 307-318 ◽  
Author(s):  
Vsevolod Katritch ◽  
Kimberly A. Reynolds ◽  
Vadim Cherezov ◽  
Michael A. Hanson ◽  
Christopher B. Roth ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Adrenergic Receptor ◽  
Transmembrane Helix ◽  
Partial Agonists ◽  
Β2 Adrenergic Receptor

scholarly journals Genetic Covariance Between γ-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of β2-Adrenergic Receptor Genetic Variation in Twins

2010 ◽  
Vol 139 (3) ◽  
pp. 836-845.e1 ◽  
Author(s):  
Rohit Loomba ◽  
Fangwen Rao ◽  
Lian Zhang ◽  
Srikrishna Khandrika ◽  
Michael G. Ziegler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Variation ◽  
Fatty Liver ◽  
Adrenergic Receptor ◽  
Genetic Covariance ◽  
Β2 Adrenergic Receptor ◽  
Glutamyl Transpeptidase

scholarly journals Probable role of β2-adrenergic receptor gene haplotype in high-altitude pulmonary oedema

Respirology ◽  
2010 ◽  
Vol 15 (4) ◽  
pp. 651-658 ◽  
Author(s):  
Tsering STOBDAN ◽  
Ram KUMAR ◽  
Ghulam MOHAMMAD ◽  
Tashi THINLAS ◽  
Tsering NORBOO ◽  
...  
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema ◽  
Adrenergic Receptor ◽  
Receptor Gene ◽  
Β2 Adrenergic Receptor ◽  
Probable Role ◽  
Gene Haplotype ◽  
Adrenergic Receptor Gene
Sign in / Sign up

Export Citation Format

Share Document